Enya Qing
@enyaqing.bsky.social
Researching virus entry, mostly coronaviruses…
Hey if you are at #ASV2025 this year feel free to stop by to chat! I won’t get to say much at my Flash Talk (below), but will have tons of time pacing by my poster (P24-94) that same evening! 😁😁😁
July 13, 2025 at 12:10 PM
Hey if you are at #ASV2025 this year feel free to stop by to chat! I won’t get to say much at my Flash Talk (below), but will have tons of time pacing by my poster (P24-94) that same evening! 😁😁😁
Reposted by Enya Qing
New preprint from Luke Snell from GSTT, Suzanne Pickering in my lab and Rui Galao, my colleague at KCL.
Here we examine in detail the evolution of the SARS CoV-2 spike in persistent infections, and essentially catch a potential variant in the act of developing. 1/n
www.biorxiv.org/content/10.1...
Here we examine in detail the evolution of the SARS CoV-2 spike in persistent infections, and essentially catch a potential variant in the act of developing. 1/n
www.biorxiv.org/content/10.1...
Antibody escape drives emergence of diverse spike haplotypes resembling variants of concern in persistent SARS-CoV-2 infections
Evolution of SARS-CoV-2 in long-term persistent infections is hypothesised to be a major source of variants of concern (VOC). However, the linkage of intra-host variants into haplotypes that reflect v...
www.biorxiv.org
April 23, 2025 at 6:42 AM
New preprint from Luke Snell from GSTT, Suzanne Pickering in my lab and Rui Galao, my colleague at KCL.
Here we examine in detail the evolution of the SARS CoV-2 spike in persistent infections, and essentially catch a potential variant in the act of developing. 1/n
www.biorxiv.org/content/10.1...
Here we examine in detail the evolution of the SARS CoV-2 spike in persistent infections, and essentially catch a potential variant in the act of developing. 1/n
www.biorxiv.org/content/10.1...
The final version of our paper on #SARSCoV2 Spike H655Y vs. Stem-helix Antibody! I really recommend reading our reader-friendly🫡Discussion section, where we explained in detail the implications of our findings on CoV entry, antibody neutralization, and viral evolution!
New paper from us! 🤩Remember #Omicron S:H655Y mutation that shifted #SARSCoV2 to endosomal entry in cell lines? H655Y lost favor because endosomal entry was not observed in primary nasal cells or animals. Here we found the actual mechanism of H655Y… 1/9
doi.org/10.1371/jour...
doi.org/10.1371/jour...
SARS-CoV-2 Omicron variations reveal mechanisms controlling cell entry dynamics and antibody neutralization
Author summary Most adaptive mutations endowing SARS-CoV-2 with increased human transmissibility and infectivity alter viral spike (S) protein structure and function. Orchestrated structural transitio...
doi.org
December 16, 2024 at 9:49 PM
The final version of our paper on #SARSCoV2 Spike H655Y vs. Stem-helix Antibody! I really recommend reading our reader-friendly🫡Discussion section, where we explained in detail the implications of our findings on CoV entry, antibody neutralization, and viral evolution!
Reposted by Enya Qing
In SARS-2 evolution, amino acid (AA) mutations get the lion’s share of attention—& rightfully so, as noncoding & synonymous nucleotide muts—which cause no AA change‚ are mostly inconsequential. But there are many exceptions, including a possible new one I find intriguing. 1/32
December 6, 2024 at 1:40 AM
In SARS-2 evolution, amino acid (AA) mutations get the lion’s share of attention—& rightfully so, as noncoding & synonymous nucleotide muts—which cause no AA change‚ are mostly inconsequential. But there are many exceptions, including a possible new one I find intriguing. 1/32
New paper from us! 🤩Remember #Omicron S:H655Y mutation that shifted #SARSCoV2 to endosomal entry in cell lines? H655Y lost favor because endosomal entry was not observed in primary nasal cells or animals. Here we found the actual mechanism of H655Y… 1/9
doi.org/10.1371/jour...
doi.org/10.1371/jour...
SARS-CoV-2 Omicron variations reveal mechanisms controlling cell entry dynamics and antibody neutralization
Author summary Most adaptive mutations endowing SARS-CoV-2 with increased human transmissibility and infectivity alter viral spike (S) protein structure and function. Orchestrated structural transitio...
doi.org
December 4, 2024 at 9:33 PM
New paper from us! 🤩Remember #Omicron S:H655Y mutation that shifted #SARSCoV2 to endosomal entry in cell lines? H655Y lost favor because endosomal entry was not observed in primary nasal cells or animals. Here we found the actual mechanism of H655Y… 1/9
doi.org/10.1371/jour...
doi.org/10.1371/jour...
Reposted by Enya Qing
Our latest #virology research is now online at Nature 🎉
Using #cryoEM and MD simulations, we show how a sugar-based receptor can trigger opening of a coronavirus spike protein through an allosteric mechanism 🍬
www.nature.com/articles/s41...
Using #cryoEM and MD simulations, we show how a sugar-based receptor can trigger opening of a coronavirus spike protein through an allosteric mechanism 🍬
www.nature.com/articles/s41...
Sialoglycan binding triggers spike opening in a human coronavirus - Nature
Binding of a sialoglycan-based primary receptor by the spike protein of the common cold human coronavirus HKU1 triggers conformational changes to a state that would allow binding to a second receptor ...
www.nature.com
October 4, 2023 at 8:41 PM
Our latest #virology research is now online at Nature 🎉
Using #cryoEM and MD simulations, we show how a sugar-based receptor can trigger opening of a coronavirus spike protein through an allosteric mechanism 🍬
www.nature.com/articles/s41...
Using #cryoEM and MD simulations, we show how a sugar-based receptor can trigger opening of a coronavirus spike protein through an allosteric mechanism 🍬
www.nature.com/articles/s41...