Kieran Deane-Alder
@endymiomatic.bsky.social
Postdoc @ Berntsson lab, Umeå University.
Pharmacology and cryo-EM mixed up in a cocktail shaker. Vitrified ice only, please.
Pharmacology and cryo-EM mixed up in a cocktail shaker. Vitrified ice only, please.
Reposted by Kieran Deane-Alder
A. baumannii is one of the most notorious multidrug-resistant pathogens, capable of forming drug-tolerant biofilms that make infections exceptionally difficult to treat. But how are these complex microbial fortresses built? Just published in Nat Comms. pubmed.ncbi.nlm.nih.gov/41654547/
Antiparallel stacking of Csu pili drives Acinetobacter baumannii 3D biofilm assembly - PubMed
Many Gram-negative nosocomial pathogens rely on adhesive filaments, known as archaic chaperone-usher pili, to establish stress- and drug-resistant, multi-layered biofilms. Here, we uncover the mechanism by which these pili build three-dimensional (3D) biofilm architectures. In situ analyses of Acine …
pubmed.ncbi.nlm.nih.gov
February 12, 2026 at 1:26 PM
A. baumannii is one of the most notorious multidrug-resistant pathogens, capable of forming drug-tolerant biofilms that make infections exceptionally difficult to treat. But how are these complex microbial fortresses built? Just published in Nat Comms. pubmed.ncbi.nlm.nih.gov/41654547/
Reposted by Kieran Deane-Alder
📣New preprint with @rberntsson.bsky.social👇We overturn the long-standing view that Gram-positive bacteria lack conjugative pili! We identify pili-forming proteins in a wide range of bacteria and show they're essential for the spread of #antibioticresistance #AMR 🧵1/6
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Pili are essential for conjugation also in many Gram-positive bacteria
Type IV secretion systems (T4SS) enable the spread of antibiotic resistance and other virulence factors. In Gram-positive bacteria, T4SSs have long been thought to lack VirB2-like proteins that form c...
www.biorxiv.org
December 30, 2025 at 6:03 PM
📣New preprint with @rberntsson.bsky.social👇We overturn the long-standing view that Gram-positive bacteria lack conjugative pili! We identify pili-forming proteins in a wide range of bacteria and show they're essential for the spread of #antibioticresistance #AMR 🧵1/6
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Look, I admire a high-res .PNG as much as the next nerd, but if your supplementary figures PDF is nearly 800 MB, you might want to explore compression...
December 12, 2025 at 8:56 AM
Look, I admire a high-res .PNG as much as the next nerd, but if your supplementary figures PDF is nearly 800 MB, you might want to explore compression...
Reposted by Kieran Deane-Alder
1. In Hamburg there is a "fully autonomous train" that for some reason has a human operator to press the ON switch first thing in the morning and the OFF switch at the end of the night. In a recent talk about AI in science, I asked the audience to consider whether they want to be like that operator.
All aboard except the driver? A fully autonomous train takes to the tracks in Germany
YouTube video by euronews
www.youtube.com
December 8, 2025 at 8:12 AM
1. In Hamburg there is a "fully autonomous train" that for some reason has a human operator to press the ON switch first thing in the morning and the OFF switch at the end of the night. In a recent talk about AI in science, I asked the audience to consider whether they want to be like that operator.
Reposted by Kieran Deane-Alder
Very cool to see our Umeå colleague and fellow structural virologist raking in a major grant. Congrats @maxrenner.bsky.social !
www.umu.se/en/news/umea...
www.umu.se/en/news/umea...
Umeå researchers aim to reveal how viruses build their factories
Max Renner explore how viruses copy themselves – to help stop future outbreaks.
www.umu.se
December 1, 2025 at 9:48 PM
Very cool to see our Umeå colleague and fellow structural virologist raking in a major grant. Congrats @maxrenner.bsky.social !
www.umu.se/en/news/umea...
www.umu.se/en/news/umea...
Reposted by Kieran Deane-Alder
I really hate it when scientists keep saying that “we need to rebuild trust in science,” because it implies that scientists are to blame for the mistrust rather than the millions of dollars of dark money that have funded political attacks on science in order to advance a far right agenda.
November 19, 2025 at 9:48 PM
I really hate it when scientists keep saying that “we need to rebuild trust in science,” because it implies that scientists are to blame for the mistrust rather than the millions of dollars of dark money that have funded political attacks on science in order to advance a far right agenda.
Reposted by Kieran Deane-Alder
how it feels to do physical activity after the age of 35
October 29, 2025 at 11:50 PM
how it feels to do physical activity after the age of 35
This is why we work on antimicrobial resistance! 🧫
🚨Drug-resistant bacteria are becoming more dangerous.
Life-saving antibiotics are losing effectiveness, increasing infection risks & limiting treatment options.
Some resistant infections can only be treated with antibiotics that are costly, difficult to access, & often unavailable 👉 bit.ly/438Ta1u
Life-saving antibiotics are losing effectiveness, increasing infection risks & limiting treatment options.
Some resistant infections can only be treated with antibiotics that are costly, difficult to access, & often unavailable 👉 bit.ly/438Ta1u
October 14, 2025 at 2:19 PM
This is why we work on antimicrobial resistance! 🧫
Reposted by Kieran Deane-Alder
🚨Drug-resistant bacteria are becoming more dangerous.
Life-saving antibiotics are losing effectiveness, increasing infection risks & limiting treatment options.
Some resistant infections can only be treated with antibiotics that are costly, difficult to access, & often unavailable 👉 bit.ly/438Ta1u
Life-saving antibiotics are losing effectiveness, increasing infection risks & limiting treatment options.
Some resistant infections can only be treated with antibiotics that are costly, difficult to access, & often unavailable 👉 bit.ly/438Ta1u
October 14, 2025 at 8:07 AM
🚨Drug-resistant bacteria are becoming more dangerous.
Life-saving antibiotics are losing effectiveness, increasing infection risks & limiting treatment options.
Some resistant infections can only be treated with antibiotics that are costly, difficult to access, & often unavailable 👉 bit.ly/438Ta1u
Life-saving antibiotics are losing effectiveness, increasing infection risks & limiting treatment options.
Some resistant infections can only be treated with antibiotics that are costly, difficult to access, & often unavailable 👉 bit.ly/438Ta1u
Reposted by Kieran Deane-Alder
Only 5 more days left to apply. Take the chance and join us trying to understand the molecular mechanisms of conjugation, in beautiful Umeå, Sweden. We are extremely well equipped, and are looking for an enthusiastic person to join our team! 😀
We are looking for a postdoc!
Join us to work in an exciting integrated structural biology project, focusing on understanding how Type 4 Secretion System facilitate horizontal gene transfer in bacteria!
Please share!
www.nature.com/naturecareer...
Join us to work in an exciting integrated structural biology project, focusing on understanding how Type 4 Secretion System facilitate horizontal gene transfer in bacteria!
Please share!
www.nature.com/naturecareer...
Postdoctoral position to study Gram-positive Type 4 Secretion Systems - Umeå, Sweden job with Umeå University | 12837918
A two-year Postdoctoral position for studies of Gram-positive Type 4 Secretion Systems that facilitate the spread of antibiotic resistance
www.nature.com
April 25, 2025 at 1:56 PM
Only 5 more days left to apply. Take the chance and join us trying to understand the molecular mechanisms of conjugation, in beautiful Umeå, Sweden. We are extremely well equipped, and are looking for an enthusiastic person to join our team! 😀
Krios 5: now in black! This does seem to be the aesthetic of the moment...
April 3, 2025 at 3:00 PM
Krios 5: now in black! This does seem to be the aesthetic of the moment...
Reposted by Kieran Deane-Alder
Postdoc opportunity, please share!
We are looking for a #postdoc to join our international team* in our quest to understand how Type 4 Secretion Systems facilitate the transfer of #antibioticresistance genes and other virulence factors in Gram-positive #bacteria.🧫👇
*5 people & 5 nationalities 🇸🇪🇳🇱🇳🇿🇺🇸🇪🇬
We are looking for a #postdoc to join our international team* in our quest to understand how Type 4 Secretion Systems facilitate the transfer of #antibioticresistance genes and other virulence factors in Gram-positive #bacteria.🧫👇
*5 people & 5 nationalities 🇸🇪🇳🇱🇳🇿🇺🇸🇪🇬
We are looking for a postdoc!
Join us to work in an exciting integrated structural biology project, focusing on understanding how Type 4 Secretion System facilitate horizontal gene transfer in bacteria!
Please share!
www.nature.com/naturecareer...
Join us to work in an exciting integrated structural biology project, focusing on understanding how Type 4 Secretion System facilitate horizontal gene transfer in bacteria!
Please share!
www.nature.com/naturecareer...
Postdoctoral position to study Gram-positive Type 4 Secretion Systems - Umeå, Sweden job with Umeå University | 12837918
A two-year Postdoctoral position for studies of Gram-positive Type 4 Secretion Systems that facilitate the spread of antibiotic resistance
www.nature.com
March 18, 2025 at 4:39 PM
Postdoc opportunity, please share!
We are looking for a #postdoc to join our international team* in our quest to understand how Type 4 Secretion Systems facilitate the transfer of #antibioticresistance genes and other virulence factors in Gram-positive #bacteria.🧫👇
*5 people & 5 nationalities 🇸🇪🇳🇱🇳🇿🇺🇸🇪🇬
We are looking for a #postdoc to join our international team* in our quest to understand how Type 4 Secretion Systems facilitate the transfer of #antibioticresistance genes and other virulence factors in Gram-positive #bacteria.🧫👇
*5 people & 5 nationalities 🇸🇪🇳🇱🇳🇿🇺🇸🇪🇬
Excited to say I've been offered a Marie Skłodowska-Curie Actions postdoc fellowship! #MSCA
I'll be staying at #umeauniversity, continuing work on the structural biology of Gram-positive type 4 secretion systems.
I'll be staying at #umeauniversity, continuing work on the structural biology of Gram-positive type 4 secretion systems.
February 10, 2025 at 3:16 PM
Excited to say I've been offered a Marie Skłodowska-Curie Actions postdoc fellowship! #MSCA
I'll be staying at #umeauniversity, continuing work on the structural biology of Gram-positive type 4 secretion systems.
I'll be staying at #umeauniversity, continuing work on the structural biology of Gram-positive type 4 secretion systems.
Last EM experiment of the year. Merry Xmas everyone ⛄
December 20, 2024 at 9:29 AM
Last EM experiment of the year. Merry Xmas everyone ⛄
When you spot a new particle in your elutions, but i turns out it's just GroEL...🙃
December 2, 2024 at 2:58 PM
When you spot a new particle in your elutions, but i turns out it's just GroEL...🙃