Nicolas Dumont
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dumontlab.bsky.social
Nicolas Dumont
@dumontlab.bsky.social
190 followers 100 following 2 posts
Associate professor at the Université de Montréal. Muscle stem cell biologist.
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dumontlab.bsky.social
I’m happy to share this perspective paper regarding senescence and senotherapeutics in myotonic dystrophy. Great work led by Cécilia Légaré in collaboration with Elise Duchesne and ⁦‪Andy Berglund labs. Very nice experience to work with these DM1 experts.

onlinelibrary.wiley.com/doi/10.1002/...
New Horizons in Myotonic Dystrophy Type 1: Cellular Senescence as a Therapeutic Target
Cellular senescence accumulates in the skeletal muscle of patients with myotonic dystrophy Type 1, leading to the production of senescence-associated secretory phenotype (SASP) factors that have detr...
onlinelibrary.wiley.com
December 28, 2024 at 7:06 PM
dumontlab.bsky.social
I’m pleased to share our recent work, led by Lupann Rieger during her Master’s thesis, which has been published in ⁦FASEB J‬⁩. We provide new insights regarding how bioactive lipids regulate fiber typing.

faseb.onlinelibrary.wiley.com/doi/10.1096/...
Transcriptomic and lipidomic profiling reveals distinct bioactive lipid signatures in slow and fast muscles and highlights the role of resolvin‐D2 in fiber type determination during myogenesis
Transcriptomics (bulk and single-nuclei RNAseq) and lipidomics (mass spectrometry) analysis showed that slow-twitch muscle (soleus) is enriched in bioactive lipids derived from docosahexaenoic acid (...
faseb.onlinelibrary.wiley.com
December 20, 2024 at 6:50 PM