Leonardo Ferreira
@drleoferreira.bsky.social
Molecular immunologist designing and developing engineered immune cell therapies for autoimmune disease, cancer, and aging.
A new engineered regulatory T cell is born. Chimeric anti-HLA receptor regulatory T cells (CHAR Tregs) inhibit antibody production by B cells from HLA sensitized transplant patients, offering a precise approach to tackle antibody-mediated organ rejection.
www.frontiersin.org/journals/imm...
www.frontiersin.org/journals/imm...
August 16, 2025 at 1:49 PM
A new engineered regulatory T cell is born. Chimeric anti-HLA receptor regulatory T cells (CHAR Tregs) inhibit antibody production by B cells from HLA sensitized transplant patients, offering a precise approach to tackle antibody-mediated organ rejection.
www.frontiersin.org/journals/imm...
www.frontiersin.org/journals/imm...
First co-edited special issue completed! Nutrition and Gut Microbiota–Immune System Interplay in Chronic Diseases @Nutrients_MDPI. Six research articles and two reviews. Read our editorial here:
www.mdpi.com/2072-6643/17...
#immunologymatters
www.mdpi.com/2072-6643/17...
#immunologymatters
May 13, 2025 at 6:54 PM
First co-edited special issue completed! Nutrition and Gut Microbiota–Immune System Interplay in Chronic Diseases @Nutrients_MDPI. Six research articles and two reviews. Read our editorial here:
www.mdpi.com/2072-6643/17...
#immunologymatters
www.mdpi.com/2072-6643/17...
#immunologymatters
Ten years of Human Islet Research Network (HIRN) & 75 years of NIDDK! Super proud to be part of the HIRN family and this historical perspective & review article. We’re at a turning point in type 1 diabetes understanding & therapy development! #immunologymatters
diabetesjournals.org/diabetes/art...
diabetesjournals.org/diabetes/art...
April 30, 2025 at 1:03 AM
Ten years of Human Islet Research Network (HIRN) & 75 years of NIDDK! Super proud to be part of the HIRN family and this historical perspective & review article. We’re at a turning point in type 1 diabetes understanding & therapy development! #immunologymatters
diabetesjournals.org/diabetes/art...
diabetesjournals.org/diabetes/art...
Human stem cell derived heart organoids (almost) invisible to the immune system. Exciting @biorxivpreprint.bsky.social with Dr. Ying Mei @cupress.bsky.social and Dr. Lance Lian @pennstateuniv.bsky.social!!!
#immunologymatters
#changingwhatspossible
www.biorxiv.org/content/10.1...
#immunologymatters
#changingwhatspossible
www.biorxiv.org/content/10.1...
April 15, 2025 at 6:25 PM
Human stem cell derived heart organoids (almost) invisible to the immune system. Exciting @biorxivpreprint.bsky.social with Dr. Ying Mei @cupress.bsky.social and Dr. Lance Lian @pennstateuniv.bsky.social!!!
#immunologymatters
#changingwhatspossible
www.biorxiv.org/content/10.1...
#immunologymatters
#changingwhatspossible
www.biorxiv.org/content/10.1...
Reposted by Leonardo Ferreira
Hypoimmunogenic hPSC-derived cardiac organoids for immune evasion and heart repair https://www.biorxiv.org/content/10.1101/2025.04.09.648007v1
April 10, 2025 at 5:46 AM
Hypoimmunogenic hPSC-derived cardiac organoids for immune evasion and heart repair https://www.biorxiv.org/content/10.1101/2025.04.09.648007v1
Reposted by Leonardo Ferreira
Hypoimmunogenic hPSC-derived cardiac organoids for immune evasion and heart repair https://www.biorxiv.org/content/10.1101/2025.04.09.648007v1
April 10, 2025 at 5:46 AM
Hypoimmunogenic hPSC-derived cardiac organoids for immune evasion and heart repair https://www.biorxiv.org/content/10.1101/2025.04.09.648007v1
The lab’s first @biorxivpreprint.bsky.social of 2025 is out! Jaime Quiroga turned the CAR Treg concept on its head and engineered Tregs that recognize and suppress allo-reactive B cells in HLA sensitized patients!
#immunologymatters
#changingwhatspossible #CHARTreg
www.biorxiv.org/content/10.1...
#immunologymatters
#changingwhatspossible #CHARTreg
www.biorxiv.org/content/10.1...
April 2, 2025 at 2:17 PM
The lab’s first @biorxivpreprint.bsky.social of 2025 is out! Jaime Quiroga turned the CAR Treg concept on its head and engineered Tregs that recognize and suppress allo-reactive B cells in HLA sensitized patients!
#immunologymatters
#changingwhatspossible #CHARTreg
www.biorxiv.org/content/10.1...
#immunologymatters
#changingwhatspossible #CHARTreg
www.biorxiv.org/content/10.1...
Reposted by Leonardo Ferreira
Chimeric anti-HLA antibody receptor engineered human regulatory T cells suppress alloantigen-specific B cells from pre-sensitized transplant recipients https://www.biorxiv.org/content/10.1101/2025.03.27.645777v1
April 2, 2025 at 12:15 AM
Chimeric anti-HLA antibody receptor engineered human regulatory T cells suppress alloantigen-specific B cells from pre-sensitized transplant recipients https://www.biorxiv.org/content/10.1101/2025.03.27.645777v1
Reposted by Leonardo Ferreira
Chimeric anti-HLA antibody receptor engineered human regulatory T cells suppress alloantigen-specific B cells from pre-sensitized transplant recipients https://www.biorxiv.org/content/10.1101/2025.03.27.645777v1
April 2, 2025 at 12:15 AM
Chimeric anti-HLA antibody receptor engineered human regulatory T cells suppress alloantigen-specific B cells from pre-sensitized transplant recipients https://www.biorxiv.org/content/10.1101/2025.03.27.645777v1
We’re presenting at American Association of Immunologists (AAI) 2025! In 2012, my PhD advisor Jack Strominger sponsored my AAI membership. In 2025, I gave my first talk at AAI. In 2022, I sponsored my PhD student Russell Cochrane’s membership. In 2025, he’s been selected for a talk at AAI! #tenyears
March 27, 2025 at 11:18 PM
We’re presenting at American Association of Immunologists (AAI) 2025! In 2012, my PhD advisor Jack Strominger sponsored my AAI membership. In 2025, I gave my first talk at AAI. In 2022, I sponsored my PhD student Russell Cochrane’s membership. In 2025, he’s been selected for a talk at AAI! #tenyears
Our work on co-engineering stem cells and regulatory T cells to treat type 1 diabetes got a Research Excellence Award by the College of Medicine at the Medical University of South Carolina!!!
@leoferreiralab @TheRussLab
#immunologymatters
#wallofscience
www.cell.com/cell-reports...
@leoferreiralab @TheRussLab
#immunologymatters
#wallofscience
www.cell.com/cell-reports...
March 21, 2025 at 12:17 AM
Our work on co-engineering stem cells and regulatory T cells to treat type 1 diabetes got a Research Excellence Award by the College of Medicine at the Medical University of South Carolina!!!
@leoferreiralab @TheRussLab
#immunologymatters
#wallofscience
www.cell.com/cell-reports...
@leoferreiralab @TheRussLab
#immunologymatters
#wallofscience
www.cell.com/cell-reports...
Outstanding time representing Torpedo Bio as a panelist at SCBio 2025! The future looks bright for innovation and entrepreneurship in South Carolina! #immunologymatters
March 7, 2025 at 2:19 AM
Outstanding time representing Torpedo Bio as a panelist at SCBio 2025! The future looks bright for innovation and entrepreneurship in South Carolina! #immunologymatters
Starting the month on a great note! Thank you Madalena Pires the Lima for the Great Interview in Descendencias magazine!
#immunologymatters #changingwhatspossible
descendencias.pt/leonardo-fer...
#immunologymatters #changingwhatspossible
descendencias.pt/leonardo-fer...
March 1, 2025 at 8:47 PM
Starting the month on a great note! Thank you Madalena Pires the Lima for the Great Interview in Descendencias magazine!
#immunologymatters #changingwhatspossible
descendencias.pt/leonardo-fer...
#immunologymatters #changingwhatspossible
descendencias.pt/leonardo-fer...
Expanding the engineered Treg universe! A treat to write this Commentary in Molecular Therapy with Russell Cochrane and Eva Allen on T cell receptor fusion construct (TRuC) Tregs! Congratulations Dimitrios Wagner on the exciting development!
www.cell.com/molecular-th...
www.cell.com/molecular-th...
www.cell.com/molecular-th...
www.cell.com/molecular-th...
March 1, 2025 at 8:39 PM
Expanding the engineered Treg universe! A treat to write this Commentary in Molecular Therapy with Russell Cochrane and Eva Allen on T cell receptor fusion construct (TRuC) Tregs! Congratulations Dimitrios Wagner on the exciting development!
www.cell.com/molecular-th...
www.cell.com/molecular-th...
www.cell.com/molecular-th...
www.cell.com/molecular-th...
How do we make CAR Tregs? Take a peek behind the curtain of the Ferreira Lab at the Medical University of South Carolina and MUSC Hollings Cancer Center!
#immunologymatters #changingwhatspossible #CARTregs
app.jove.com/v/67200/gene...
#immunologymatters #changingwhatspossible #CARTregs
app.jove.com/v/67200/gene...
February 19, 2025 at 6:44 PM
How do we make CAR Tregs? Take a peek behind the curtain of the Ferreira Lab at the Medical University of South Carolina and MUSC Hollings Cancer Center!
#immunologymatters #changingwhatspossible #CARTregs
app.jove.com/v/67200/gene...
#immunologymatters #changingwhatspossible #CARTregs
app.jove.com/v/67200/gene...
Scaling up! Half a billion human T cells gently genetically modified using hydroporation with great yield, cytokine profile, and tumor killing activity in vivo!
#immunologymatters #changingwhatspossible
www.nature.com/articles/s41...
#immunologymatters #changingwhatspossible
www.nature.com/articles/s41...
February 19, 2025 at 6:33 PM
Scaling up! Half a billion human T cells gently genetically modified using hydroporation with great yield, cytokine profile, and tumor killing activity in vivo!
#immunologymatters #changingwhatspossible
www.nature.com/articles/s41...
#immunologymatters #changingwhatspossible
www.nature.com/articles/s41...
Outstanding time in Infinita City, Prospera immersing myself in the latest technologies and strategies for maximum life extension! Thank you Max Unfried for the kind invitation. #immunologymatters #changingwhatspossible
www.infinita.city/forever-2025...
www.infinita.city/forever-2025...
February 8, 2025 at 4:55 PM
Outstanding time in Infinita City, Prospera immersing myself in the latest technologies and strategies for maximum life extension! Thank you Max Unfried for the kind invitation. #immunologymatters #changingwhatspossible
www.infinita.city/forever-2025...
www.infinita.city/forever-2025...
Thank you RDP Internacional – Radio Portugal (@rtppt) for featuring our work on developing genetically modified stem cells and immune cells to treat type 1 diabetes! #immunologymatters #changingwhatspossible #endT1D
rdpinternacional.rtp.pt/estados-unid...
www.cell.com/cell-reports...
rdpinternacional.rtp.pt/estados-unid...
www.cell.com/cell-reports...
February 6, 2025 at 6:25 PM
Thank you RDP Internacional – Radio Portugal (@rtppt) for featuring our work on developing genetically modified stem cells and immune cells to treat type 1 diabetes! #immunologymatters #changingwhatspossible #endT1D
rdpinternacional.rtp.pt/estados-unid...
www.cell.com/cell-reports...
rdpinternacional.rtp.pt/estados-unid...
www.cell.com/cell-reports...
Changing the course in type 1 diabetes! Energized after co-chairing, speaking, and being a panelist at the 10-Year Anniversary Symposium Organized by The Human Islet Research Network at the NIH!
All lectures available online. #immunologymatters
videocast.nih.gov/watch=56591
All lectures available online. #immunologymatters
videocast.nih.gov/watch=56591
February 4, 2025 at 4:20 AM
Changing the course in type 1 diabetes! Energized after co-chairing, speaking, and being a panelist at the 10-Year Anniversary Symposium Organized by The Human Islet Research Network at the NIH!
All lectures available online. #immunologymatters
videocast.nih.gov/watch=56591
All lectures available online. #immunologymatters
videocast.nih.gov/watch=56591
I am the Director of the Immunobiology graduate course at the Medical University of South Carolina! Co-Director Dr. Radhika Gudi and I are excited to take first-year Ph.D. students on this journey through immunoland! #immunologymatters #cgs790
January 30, 2025 at 2:58 AM
I am the Director of the Immunobiology graduate course at the Medical University of South Carolina! Co-Director Dr. Radhika Gudi and I are excited to take first-year Ph.D. students on this journey through immunoland! #immunologymatters #cgs790