Dino Luethi
@dinoluethi.bsky.social
Neuropharmacologist & bioanalyst @ University Hospital Basel. Interested in stimulants & psychedelics.
50 years ago, Alexander Shulgin showed that 4-alkylated 2,5-dimethoxyamphetamines peak in potency with 2–3 carbon chains. We suggest longer chains reduce psychedelic-like effects mainly due to poor brain penetration, not reduced receptor activity. doi.org/10.1038/s413...
#psychedelics
#psychedelics
The 4-alkyl chain length of 2,5-dimethoxyamphetamines differentially affects in vitro serotonin receptor actions versus in vivo psychedelic-like effects - Molecular Psychiatry
Molecular Psychiatry - The 4-alkyl chain length of 2,5-dimethoxyamphetamines differentially affects in vitro serotonin receptor actions versus in vivo psychedelic-like effects
doi.org
November 5, 2025 at 1:09 PM
50 years ago, Alexander Shulgin showed that 4-alkylated 2,5-dimethoxyamphetamines peak in potency with 2–3 carbon chains. We suggest longer chains reduce psychedelic-like effects mainly due to poor brain penetration, not reduced receptor activity. doi.org/10.1038/s413...
#psychedelics
#psychedelics
A recent study suggests that no dose adjustment of #LSD is necessary in the presence of an SSRI that inhibits CYP2D6. #psychedelics ascpt.onlinelibrary.wiley.com/doi/10.1002/...
Acute Effects and Pharmacokinetics of LSD after Paroxetine or Placebo Pre‐Administration in a Randomized, Double‐Blind, Cross‐Over Phase I Trial
Psychedelics, such as psilocybin and lysergic acid diethylamide (LSD), are being investigated for the treatment of depressive and anxiety disorders, for which concomitant treatment with selective ser...
ascpt.onlinelibrary.wiley.com
March 1, 2025 at 7:05 PM
A recent study suggests that no dose adjustment of #LSD is necessary in the presence of an SSRI that inhibits CYP2D6. #psychedelics ascpt.onlinelibrary.wiley.com/doi/10.1002/...
Acute dose-dependent effects and self-guided titration of continuous #DMT infusions. www.nature.com/articles/s41...
Acute dose-dependent effects and self-guided titration of continuous N,N-dimethyltryptamine infusions in a double-blind placebo-controlled study in healthy participants - Neuropsychopharmacology
Neuropsychopharmacology - Acute dose-dependent effects and self-guided titration of continuous N,N-dimethyltryptamine infusions in a double-blind placebo-controlled study in healthy participants
www.nature.com
December 19, 2024 at 4:53 PM
Acute dose-dependent effects and self-guided titration of continuous #DMT infusions. www.nature.com/articles/s41...
Nice to meet you all here!
1) I began with characterizing designer drugs and later transitioned to bioanalysis of psychedelics
2) I'm mostly setting up methods for the bioanalysis of upcoming phase I studies
3) Arrested Development is my favorite TV show—I should watch it once again soon
1) I began with characterizing designer drugs and later transitioned to bioanalysis of psychedelics
2) I'm mostly setting up methods for the bioanalysis of upcoming phase I studies
3) Arrested Development is my favorite TV show—I should watch it once again soon
Bluesky Psychedelics People: Let's (re-)intro ourselves to one another!
Quote this post and tell us:
1) What you do in the field
2) A project you're currently working on
3) A show/film/book you're enjoying
Quote this post and tell us:
1) What you do in the field
2) A project you're currently working on
3) A show/film/book you're enjoying
November 17, 2024 at 7:53 PM
Nice to meet you all here!
1) I began with characterizing designer drugs and later transitioned to bioanalysis of psychedelics
2) I'm mostly setting up methods for the bioanalysis of upcoming phase I studies
3) Arrested Development is my favorite TV show—I should watch it once again soon
1) I began with characterizing designer drugs and later transitioned to bioanalysis of psychedelics
2) I'm mostly setting up methods for the bioanalysis of upcoming phase I studies
3) Arrested Development is my favorite TV show—I should watch it once again soon
Reposted by Dino Luethi
Here is a starter pack I put together featuring all the psychedelic science researchers and journalists I could find on here. Let me know who I'm missing. It'd be great to get the conversation going on this platform go.bsky.app/NPvFX41
November 12, 2024 at 9:56 PM
Here is a starter pack I put together featuring all the psychedelic science researchers and journalists I could find on here. Let me know who I'm missing. It'd be great to get the conversation going on this platform go.bsky.app/NPvFX41
Reposted by Dino Luethi
Thrilled to share the final product for an excellent collaboration with A. Sherwood & co at Usona Institute 😎.
Extending norpsilocin by a single methyl group to N-ethyl is sufficient for psychedelic-like activity in mice. Full story & SAR linked below:
pubs.acs.org/doi/10.1021/...
Extending norpsilocin by a single methyl group to N-ethyl is sufficient for psychedelic-like activity in mice. Full story & SAR linked below:
pubs.acs.org/doi/10.1021/...
January 8, 2024 at 3:54 PM
Thrilled to share the final product for an excellent collaboration with A. Sherwood & co at Usona Institute 😎.
Extending norpsilocin by a single methyl group to N-ethyl is sufficient for psychedelic-like activity in mice. Full story & SAR linked below:
pubs.acs.org/doi/10.1021/...
Extending norpsilocin by a single methyl group to N-ethyl is sufficient for psychedelic-like activity in mice. Full story & SAR linked below:
pubs.acs.org/doi/10.1021/...
Very nice early Christmas gift from our research group. Some insights into Albert Hofmann's work at Sandoz from the Novartis archives. A very nice read while waiting for the mass spec to measure our latest LSD plasma samples. #psychedelics #neuroskyence
November 17, 2023 at 4:08 PM
Very nice early Christmas gift from our research group. Some insights into Albert Hofmann's work at Sandoz from the Novartis archives. A very nice read while waiting for the mass spec to measure our latest LSD plasma samples. #psychedelics #neuroskyence