@dede20240.bsky.social
Reposted
Our latest research highlight covers a paper in Science on an in vivo CAR-T cell therapy platform based on mRNA-loaded lipid nanoparticles nature.com/articles/d41...
AbbVie recently paid $2.1 billion to buy the company that developed the platform, Capstan Therapeutics nature.com/articles/d41...
AbbVie recently paid $2.1 billion to buy the company that developed the platform, Capstan Therapeutics nature.com/articles/d41...
August 5, 2025 at 3:20 PM
Our latest research highlight covers a paper in Science on an in vivo CAR-T cell therapy platform based on mRNA-loaded lipid nanoparticles nature.com/articles/d41...
AbbVie recently paid $2.1 billion to buy the company that developed the platform, Capstan Therapeutics nature.com/articles/d41...
AbbVie recently paid $2.1 billion to buy the company that developed the platform, Capstan Therapeutics nature.com/articles/d41...
Reposted
Dual-payload antibody-drug conjugates move into first oncology clinical trials nature.com/articles/d41...
Find out why a rapidly growing number of companies are betting that two different warheads on ADCs for cancer could be better than one in this news story in the August issue
Find out why a rapidly growing number of companies are betting that two different warheads on ADCs for cancer could be better than one in this news story in the August issue
August 6, 2025 at 3:19 PM
Dual-payload antibody-drug conjugates move into first oncology clinical trials nature.com/articles/d41...
Find out why a rapidly growing number of companies are betting that two different warheads on ADCs for cancer could be better than one in this news story in the August issue
Find out why a rapidly growing number of companies are betting that two different warheads on ADCs for cancer could be better than one in this news story in the August issue
Reposted
The aryl hydrocarbon receptor has become a promising target for therapeutic immune modulation in inflammatory diseases, cancer and infections. Read about the field in this review in the August issue
www.nature.com/articles/s41...
rdcu.be/eBJKu
www.nature.com/articles/s41...
rdcu.be/eBJKu
The aryl hydrocarbon receptor: a rehabilitated target for therapeutic immune modulation - Nature Reviews Drug Discovery
The aryl hydrocarbon receptor (AHR) mediates the toxic effects of environmental pollutants and regulates innate and adaptive immune responses. This Review discusses how, in the past, AHR activation wa...
www.nature.com
August 21, 2025 at 2:21 PM
The aryl hydrocarbon receptor has become a promising target for therapeutic immune modulation in inflammatory diseases, cancer and infections. Read about the field in this review in the August issue
www.nature.com/articles/s41...
rdcu.be/eBJKu
www.nature.com/articles/s41...
rdcu.be/eBJKu
Reposted
For readers interested in bispecific antibodies in oncology, such as Akeso's VEGF x PD1 bispecific ivonescimab, here's a comprehensive review
www.nature.com/articles/s41...
rdcu.be/eCHRY
www.nature.com/articles/s41...
rdcu.be/eCHRY
The present and future of bispecific antibodies for cancer therapy - Nature Reviews Drug Discovery
Bispecific antibodies (bsAbs) can mediate therapeutic effects beyond those of natural monospecific antibodies. This Review provides an overview of recent developments in the field of bsAbs for cancer ...
www.nature.com
August 27, 2025 at 2:51 PM
For readers interested in bispecific antibodies in oncology, such as Akeso's VEGF x PD1 bispecific ivonescimab, here's a comprehensive review
www.nature.com/articles/s41...
rdcu.be/eCHRY
www.nature.com/articles/s41...
rdcu.be/eCHRY
Reposted
Cellular senescence is a therapeutic target for cancer and central nervous system disorders. Here are two reviews on progress and challenges: nature.com/articles/s41... (Readcube rdcu.be/eCTbQ)
nature.com/articles/s41...
(Readcube rdcu.be/eCTbB)
nature.com/articles/s41...
(Readcube rdcu.be/eCTbB)
Senescence as a therapeutic target in cancer and age-related diseases - Nature Reviews Drug Discovery
Recent progress in understanding senescence has spurred interest in the development of approaches that target senescent cells. This Review assesses the current status of senotherapies, such as senolyt...
nature.com
August 28, 2025 at 2:07 PM
Cellular senescence is a therapeutic target for cancer and central nervous system disorders. Here are two reviews on progress and challenges: nature.com/articles/s41... (Readcube rdcu.be/eCTbQ)
nature.com/articles/s41...
(Readcube rdcu.be/eCTbB)
nature.com/articles/s41...
(Readcube rdcu.be/eCTbB)
Reposted
Our September issue is live! Read about targeting neutrophils for cancer therapy, application of new approach methodologies in safety assessment, the gut microbiome and cancer immunotherapy, and more here www.nature.com/nrd/volumes/...
September 2, 2025 at 2:40 PM
Our September issue is live! Read about targeting neutrophils for cancer therapy, application of new approach methodologies in safety assessment, the gut microbiome and cancer immunotherapy, and more here www.nature.com/nrd/volumes/...
Reposted
New online: Synthetic lethality in cancer drug discovery: challenges and opportunities
www.nature.com/articles/s41...
rdcu.be/eFDCl
This Review discusses advances in the discovery and validation of synthetic lethal pairs, and the development of drugs that target them
www.nature.com/articles/s41...
rdcu.be/eFDCl
This Review discusses advances in the discovery and validation of synthetic lethal pairs, and the development of drugs that target them
September 11, 2025 at 2:37 PM
New online: Synthetic lethality in cancer drug discovery: challenges and opportunities
www.nature.com/articles/s41...
rdcu.be/eFDCl
This Review discusses advances in the discovery and validation of synthetic lethal pairs, and the development of drugs that target them
www.nature.com/articles/s41...
rdcu.be/eFDCl
This Review discusses advances in the discovery and validation of synthetic lethal pairs, and the development of drugs that target them
Reposted
In vivo CAR-T cell therapy
www.nature.com/articles/s41...
rdcu.be/eI7zH
This new Review discusses how technological advances that remove the need for ex vivo manipulation and chemotherapeutic conditioning could enable wider application of CAR-T cell therapies in blood cancers and autoimmune diseases
www.nature.com/articles/s41...
rdcu.be/eI7zH
This new Review discusses how technological advances that remove the need for ex vivo manipulation and chemotherapeutic conditioning could enable wider application of CAR-T cell therapies in blood cancers and autoimmune diseases
October 2, 2025 at 2:15 PM
In vivo CAR-T cell therapy
www.nature.com/articles/s41...
rdcu.be/eI7zH
This new Review discusses how technological advances that remove the need for ex vivo manipulation and chemotherapeutic conditioning could enable wider application of CAR-T cell therapies in blood cancers and autoimmune diseases
www.nature.com/articles/s41...
rdcu.be/eI7zH
This new Review discusses how technological advances that remove the need for ex vivo manipulation and chemotherapeutic conditioning could enable wider application of CAR-T cell therapies in blood cancers and autoimmune diseases
Reposted
马斯克在大肆削减美国联邦政府基金包括科研资金的同时，大肆给自己从纳税人那里捞钱。去年他的公司从联邦政府拿了38亿美元资金，今年将会拿得多得多，美国政府已改变拜登时期的决定，允许星链去分420亿美元宽带项目大蛋糕。
March 23, 2025 at 9:54 PM
马斯克在大肆削减美国联邦政府基金包括科研资金的同时，大肆给自己从纳税人那里捞钱。去年他的公司从联邦政府拿了38亿美元资金，今年将会拿得多得多，美国政府已改变拜登时期的决定，允许星链去分420亿美元宽带项目大蛋糕。
PAGERs provide modular, customizable G-protein-coupled receptors for cell-signalling studies.
December 25, 2024 at 4:23 AM
PAGERs provide modular, customizable G-protein-coupled receptors for cell-signalling studies.
Physician-researchers with City of Hope have developed a way to add features to T cells to help them overcome mechanisms of chimeric antigen receptor (CAR) T ce…
December 25, 2024 at 4:21 AM
Physician-researchers with City of Hope have developed a way to add features to T cells to help them overcome mechanisms of chimeric antigen receptor (CAR) T ce…
The Oracle of Omaha has recommended many books. But these are some of his top choices.
December 15, 2024 at 6:19 AM
The Oracle of Omaha has recommended many books. But these are some of his top choices.
Serious side effect of using CRISPR-Cas gene scissors uncovered: AZD7648 molecule can destroy parts of genome
December 9, 2024 at 6:38 AM
Serious side effect of using CRISPR-Cas gene scissors uncovered: AZD7648 molecule can destroy parts of genome
Reposted
Wonderful art amazing like super duper amazing......
Credit to: Albert Danil
Credit to: Albert Danil
December 1, 2024 at 5:27 AM
Wonderful art amazing like super duper amazing......
Credit to: Albert Danil
Credit to: Albert Danil
Reposted
A small sampling of why Elon wants to eliminate federal watchdog agencies...
November 30, 2024 at 7:28 PM
A small sampling of why Elon wants to eliminate federal watchdog agencies...
Reposted
尔湾有几家中国移民家庭，子女回家过感恩节，父母因为川普获胜得意忘形，让子女知道了他们是川粉，闹得不欢而散。父母还在网上抱怨子女在加州被民主党“洗脑”。以前看不清川普是什么样的人还可理解，到现在还当川粉，不是政治观点问题，而是人性问题。
November 30, 2024 at 7:29 AM
尔湾有几家中国移民家庭，子女回家过感恩节，父母因为川普获胜得意忘形，让子女知道了他们是川粉，闹得不欢而散。父母还在网上抱怨子女在加州被民主党“洗脑”。以前看不清川普是什么样的人还可理解，到现在还当川粉，不是政治观点问题，而是人性问题。
Reposted
加州高铁的列车将100%用太阳能发电，计划在2026年开始铺设太阳能线路，2030年运行。加州大学洛杉矶分校附近将建电动车充电道路，地下安装感应充电线圈，电动公交车在路上无线充电，计划2028年洛杉矶奥运会时开通。
November 30, 2024 at 6:37 AM
加州高铁的列车将100%用太阳能发电，计划在2026年开始铺设太阳能线路，2030年运行。加州大学洛杉矶分校附近将建电动车充电道路，地下安装感应充电线圈，电动公交车在路上无线充电，计划2028年洛杉矶奥运会时开通。
Reposted
美国下一任国防部长，连他妈妈都骂他没有任何道德感。美国即将进入人渣执政的新时代。
November 30, 2024 at 4:37 AM
美国下一任国防部长，连他妈妈都骂他没有任何道德感。美国即将进入人渣执政的新时代。
Reposted
美国低收入家庭标准：三口之家年收入不到$56,600，每月工资花光，没有储蓄用于应急、退休，觉得房租、交通费用、医疗费太重。中产阶级家庭标准：三口之家年收入$56,600到$169,800，能够轻松付账单，能负担得起偶尔出去旅游、下馆子，觉得买房、交大学学费负担重但能做到，有储蓄但觉得没存够。上层阶级家庭标准：三口之家年收入超过$169,800，投资是为了赚更多钱而不只是储蓄，负债是出于财务策略而不是负担，轻松享受旅游、下馆子和买得起第二套房。（据Benzinga）
November 29, 2024 at 1:35 AM
美国低收入家庭标准：三口之家年收入不到$56,600，每月工资花光，没有储蓄用于应急、退休，觉得房租、交通费用、医疗费太重。中产阶级家庭标准：三口之家年收入$56,600到$169,800，能够轻松付账单，能负担得起偶尔出去旅游、下馆子，觉得买房、交大学学费负担重但能做到，有储蓄但觉得没存够。上层阶级家庭标准：三口之家年收入超过$169,800，投资是为了赚更多钱而不只是储蓄，负债是出于财务策略而不是负担，轻松享受旅游、下馆子和买得起第二套房。（据Benzinga）
这才当上几天？就被拿下！还解放台湾！噢！我的梦啊😂https://x.com/ft/status/1861582921351471217?s=12
November 27, 2024 at 3:55 AM
这才当上几天？就被拿下！还解放台湾！噢！我的梦啊😂https://x.com/ft/status/1861582921351471217?s=12
Reposted
Trump alone didn't beat the justice system.
He had help.
It took Oligarchs relentlessly amplifying his lies on their media platforms.
Ethically compromised members of the Supreme Court.
70+ million willing to vote for a convicted felon.
There's a lot to fix. But it can be fixed. It must.
He had help.
It took Oligarchs relentlessly amplifying his lies on their media platforms.
Ethically compromised members of the Supreme Court.
70+ million willing to vote for a convicted felon.
There's a lot to fix. But it can be fixed. It must.
November 25, 2024 at 10:28 PM
Trump alone didn't beat the justice system.
He had help.
It took Oligarchs relentlessly amplifying his lies on their media platforms.
Ethically compromised members of the Supreme Court.
70+ million willing to vote for a convicted felon.
There's a lot to fix. But it can be fixed. It must.
He had help.
It took Oligarchs relentlessly amplifying his lies on their media platforms.
Ethically compromised members of the Supreme Court.
70+ million willing to vote for a convicted felon.
There's a lot to fix. But it can be fixed. It must.
这太值了！狠狠地打！Storm Shadow Strike Reportedly Kills 500 North Korean Soldiers and 18 Russian Officers in Kursk Region
November 23, 2024 at 11:35 PM
这太值了！狠狠地打！Storm Shadow Strike Reportedly Kills 500 North Korean Soldiers and 18 Russian Officers in Kursk Region
早就该这样！为什么实至今日才放行
BREAKING: Ukraine has fired US-made long-range missiles into Russia's Bryansk region, Russian state media reports
Ukraine fires US-made longer-range missiles into Russia | CNN
Ukraine has fired US-made ATACMS missiles into Russia’s Bryansk region, Russia’s Defense Ministry said, after the Biden administration gave Kyiv the green light to use the longer-range weapons against...
www.cnn.com
November 19, 2024 at 1:29 PM
早就该这样！为什么实至今日才放行
Reposted
Based on recent scuttlebutt, it appears the Trump Crime Syndicate isn't confident they can suppress the Matt Gaetz Ethics report.
They're now focused on pressuring the Senate to ignore it and confirm him anyway.
They're now focused on pressuring the Senate to ignore it and confirm him anyway.
November 19, 2024 at 1:16 PM
Based on recent scuttlebutt, it appears the Trump Crime Syndicate isn't confident they can suppress the Matt Gaetz Ethics report.
They're now focused on pressuring the Senate to ignore it and confirm him anyway.
They're now focused on pressuring the Senate to ignore it and confirm him anyway.
解除限令了，战场会发生什么变化？
The U.S. is allowing Ukraine to use the powerful long-range weapons to strike in and around Kursk — the same region where some 10,000 North Korean troops were recently deployed.
In a first, Biden allows Ukraine to strike Russia with U.S. long-range weapons
The U.S. is allowing Ukraine to use the powerful long-range weapons to strike in and around Kursk — the same region where some 10,000 North Korean troops were recently deployed.
www.npr.org
November 17, 2024 at 9:10 PM
解除限令了，战场会发生什么变化？