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GLP1 (those weight loss drugs) seem to get into the news every other week for some other beneficial effect they end up doing. Now Alzheimer's? A big study with trials already going on is published alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Real‐world observations of GLP‐1 receptor agonists and SGLT‐2 inhibitors as potential treatments for Alzheimer's disease
INTRODUCTION Glucagon-like peptide-1 (GLP-1) receptor agonists, sodium-glucose cotransporter-2 (SGLT-2) inhibitors, and dipeptidyl peptidase-4 (DPP-4) inhibitors have potential beneficial effects in...
alz-journals.onlinelibrary.wiley.com
November 13, 2025 at 10:52 AM
GLP1 (those weight loss drugs) seem to get into the news every other week for some other beneficial effect they end up doing. Now Alzheimer's? A big study with trials already going on is published alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
You've heard of NAD+ for anti-aging (and you can go out and just buy it) but how about for fighting Alzheimer's? www.science.org/doi/10.1126/... a really long paper talks about it, but how to get it directly to human brains where it can help?
NAD+ reverses Alzheimer’s neurological deficits via regulating differential alternative RNA splicing of EVA1C
A mechanism describing how NAD+ regulates alternative RNA splicing to inhibit Alzheimer’s disease is unveiled.
www.science.org
November 13, 2025 at 10:38 AM
You've heard of NAD+ for anti-aging (and you can go out and just buy it) but how about for fighting Alzheimer's? www.science.org/doi/10.1126/... a really long paper talks about it, but how to get it directly to human brains where it can help?
What is the Lysosome? It's part of the body's recycling system. www.sciencedaily.com/releases/202... Helping it in a lab removes signs of cellular aging. But now that it's known what it does, we've got to figure out how to help/activate/etc the Lysosome.
A hidden cellular cleanup trick could reverse aging
Researchers found that the body’s natural recycling system, the lysosome, plays a vital role in removing the protein that drives premature aging. When this system breaks down, aging speeds up. By reac...
www.sciencedaily.com
November 13, 2025 at 10:34 AM
What is the Lysosome? It's part of the body's recycling system. www.sciencedaily.com/releases/202... Helping it in a lab removes signs of cellular aging. But now that it's known what it does, we've got to figure out how to help/activate/etc the Lysosome.
A decade in days? That's what's going on with Notre Dame's new research on PH Sensitive proteins. phys.org/news/2025-11... It's important because you can get really targeted therapies (that leave healthy cells alone) with it.
Computational process could condense decades of disease biology research into days
At 10 one-millionths of a meter wide, a single human cell is tiny. But something even smaller exerts an enormous influence on everything a cell does: proton concentration, or pH. On the microscopic le...
phys.org
November 13, 2025 at 8:48 AM
A decade in days? That's what's going on with Notre Dame's new research on PH Sensitive proteins. phys.org/news/2025-11... It's important because you can get really targeted therapies (that leave healthy cells alone) with it.
The evils of the Epstein-Barr virus continue (remember that post a couple of days ago where various viruses are implicated in seemingly unrelated diseases www.reddit.com/r/science/co... even reddit is picking up on it. But, they're working on a vaccine for it now: faster please
From the science community on Reddit: Epstein-Barr virus appears to be trigger of lupus disease, say scientists. Connection of near-ubiquitous EBV to autoimmune disease affecting about 1 in 1,000 peop...
Explore this post and more from the science community
www.reddit.com
November 13, 2025 at 8:39 AM
The evils of the Epstein-Barr virus continue (remember that post a couple of days ago where various viruses are implicated in seemingly unrelated diseases www.reddit.com/r/science/co... even reddit is picking up on it. But, they're working on a vaccine for it now: faster please
Hopefully good news for medicine as Eli Lilly goes with Insilico Medicine to the tune of 100 million dollars. They're trying to get life saving drugs onto the market faster, hopefully this big money collab will pay off.
November 13, 2025 at 8:18 AM
Hopefully good news for medicine as Eli Lilly goes with Insilico Medicine to the tune of 100 million dollars. They're trying to get life saving drugs onto the market faster, hopefully this big money collab will pay off.
More about Klotho, and tackling ALS. longevity.technology/news/klotho-... a general informative article.
Klotho, neuroprotection and the biology of aging
Klotho Neurosciences CEO on why Klotho’s role in aging makes it more than a longevity gene – and why ALS may prove its most telling test.
longevity.technology
November 12, 2025 at 10:42 AM
More about Klotho, and tackling ALS. longevity.technology/news/klotho-... a general informative article.
Popular channel The Big Think starts commenting on longevity with a video. x.com/bigthink/sta... They push healthspan (a detour) and talk about the usual/tired old 'moral debate' on living longer, but at least they're giving it attention.
Big Think on X: "The greatest revolution in the history of medicine | Andrew Steele @statto 00:00 Rethinking longevity 01:27 Understanding aging 02:58 Biological age and epigenetics 04:29 New frontiers in longevity science 08:04 Future possibilities and ethical questions 10:24 The moral debate https://t.co/qFH2b2MT1Y" / X
The greatest revolution in the history of medicine | Andrew Steele @statto 00:00 Rethinking longevity 01:27 Understanding aging 02:58 Biological age and epigenetics 04:29 New frontiers in longevity science 08:04 Future possibilities and ethical questions 10:24 The moral debate https://t.co/qFH2b2MT1Y
x.com
November 12, 2025 at 10:41 AM
Popular channel The Big Think starts commenting on longevity with a video. x.com/bigthink/sta... They push healthspan (a detour) and talk about the usual/tired old 'moral debate' on living longer, but at least they're giving it attention.
Another Chinese start up looks to longevity, this time its Lonvi Bio Sciences. They're after the grape seed derived PCC1 too. Lots of companies entering the scene means competition for progress, and that's great for everyone. x.com/SciTechera/s...
SciTech Era on X: "China’s scientists may have found a way to slow aging itself Researchers at Lonvi Biosciences in Shenzhen have developed a potential anti-aging drug derived from grape seed extract (compound PCC1) and it’s already showing life extending results in mice. In preclinical studies, https://t.co/B4lA8dhupg" / X
China’s scientists may have found a way to slow aging itself Researchers at Lonvi Biosciences in Shenzhen have developed a potential anti-aging drug derived from grape seed extract (compound PCC1) and it’s already showing life extending results in mice. In preclinical studies, https://t.co/B4lA8dhupg
x.com
November 12, 2025 at 10:23 AM
Another Chinese start up looks to longevity, this time its Lonvi Bio Sciences. They're after the grape seed derived PCC1 too. Lots of companies entering the scene means competition for progress, and that's great for everyone. x.com/SciTechera/s...
Pills are often dismissed as a crutch or cop-out, but when a flavor is 'horrifyingly disgusting' but the benefit is really good, just grab the pills. www.frontiersin.org/journals/car... In-depth study of nattokinase fairly high amount (1000fu/3 pills) vs cholesterol.
Frontiers | Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants
Nattokinase (NK), known as a potent fibrinolytic and antithrombotic agent, has been shown to have antiatherosclerotic and lipid-lowering effects. However, da...
www.frontiersin.org
November 12, 2025 at 9:44 AM
Pills are often dismissed as a crutch or cop-out, but when a flavor is 'horrifyingly disgusting' but the benefit is really good, just grab the pills. www.frontiersin.org/journals/car... In-depth study of nattokinase fairly high amount (1000fu/3 pills) vs cholesterol.
People anywhere would probably benefit from inexpensive-ish (6 dollars or so) prepared hot healthier meals (no fast food stuff). How many meals 120 an hour! How much tipping & cleaning? None! How's it done? Robots! interestingengineering.com/innovation/a... no pipe-dream, it's already live now.
Robotic kitchen in a box cooks, cleans and serves 120 meals an hour
Meet the AI kitchen that never tires, Circus’ CA-1 robot cooks, serves, and cleans at REWE’s new ‘Fresh & Smart’ outlet.
interestingengineering.com
November 12, 2025 at 3:48 AM
People anywhere would probably benefit from inexpensive-ish (6 dollars or so) prepared hot healthier meals (no fast food stuff). How many meals 120 an hour! How much tipping & cleaning? None! How's it done? Robots! interestingengineering.com/innovation/a... no pipe-dream, it's already live now.
Finland fights Macular Degeneration with a special light www.aalto.fi/en/news/new-... that creates heat to activate healing cells. But it's slow, at 3 years out and needs to be repeated frequently.
New macular degeneration treatment the first to halt disease’s progression | Aalto University
Aalto University researchers have uncovered a promising way to treat the dry form of the age- related macular degeneration (AMD) in the early diagnosis phase that could potentially stop its progression. The novel treatment approach aims to strengthen the protective mechanisms of affected cells using heat, explains Professor Ari Koskelainen.
www.aalto.fi
November 11, 2025 at 10:13 AM
Finland fights Macular Degeneration with a special light www.aalto.fi/en/news/new-... that creates heat to activate healing cells. But it's slow, at 3 years out and needs to be repeated frequently.
Denmark starts trials to stop Alzheimer's longevity.technology/news/danish-... their new approach focuses on the brain's own protective measures. Their results will be mid 2026. Every new approach counts, let's go faster
Danish biotech kicks off first-in-human Alzheimer's trial
Muna Therapeutics targets brain resilience with drug designed to enhance neural health by harnessing established protective mechanisms.
longevity.technology
November 11, 2025 at 10:03 AM
Denmark starts trials to stop Alzheimer's longevity.technology/news/danish-... their new approach focuses on the brain's own protective measures. Their results will be mid 2026. Every new approach counts, let's go faster
CRISPR for cholesterol? The trial has already started. (Familial high cholesterol can't be controlled through good diet alone) newsroom.heart.org/news/first-i... cholesterol is important, but too much is a health risk.
First-in-human trial of CRISPR gene-editing therapy safely lowered cholesterol, triglycerides
Research Highlights: In a Phase 1, first-in-human trial, a one-time infusion of an investigational CRISPR-Cas9 therapy targeting angiopoietin-like protein 3 (ANGPTL3) was safe and reduced LDL choleste...
newsroom.heart.org
November 11, 2025 at 9:55 AM
CRISPR for cholesterol? The trial has already started. (Familial high cholesterol can't be controlled through good diet alone) newsroom.heart.org/news/first-i... cholesterol is important, but too much is a health risk.
Official government guy recognizes the problem of menopause x.com/HHS_Jim/stat... (good) the blackbox warning will be off the estrogen replaces (also good) but not everyone benefits from it (not good) Still, likely a step in the right direction. Read up if you're over 40...
Deputy Secretary Jim O'Neill on X: "Someday, science will help us slow or reverse all the damage of aging. A good safe way to address estrogen depletion already exists, and today we are removing a barrier to this treatment. Many more women can reduce their risk of fracture, heart disease, and immune and cognitive" / X
Someday, science will help us slow or reverse all the damage of aging. A good safe way to address estrogen depletion already exists, and today we are removing a barrier to this treatment. Many more women can reduce their risk of fracture, heart disease, and immune and cognitive
x.com
November 11, 2025 at 9:45 AM
Official government guy recognizes the problem of menopause x.com/HHS_Jim/stat... (good) the blackbox warning will be off the estrogen replaces (also good) but not everyone benefits from it (not good) Still, likely a step in the right direction. Read up if you're over 40...
NAD was already being researched for anti-aging but now it restores memory in Alzheimers tissue samples? medicalxpress.com/news/2025-11... The study doesn't know why but you can get NMN and NAD+ now as supplements.
NAD⁺ restores memory in Alzheimer's disease models by correcting RNA errors
Alzheimer's disease (AD), the leading cause of dementia, affects nearly 40 million individuals globally, resulting in a gradual loss of memory and independence. Despite extensive research over the pas...
medicalxpress.com
November 11, 2025 at 9:18 AM
NAD was already being researched for anti-aging but now it restores memory in Alzheimers tissue samples? medicalxpress.com/news/2025-11... The study doesn't know why but you can get NMN and NAD+ now as supplements.
A list of 100 open problems about aging science is a good starter on where to direct some LLMs link.springer.com/article/10.1...
Open problems in ageing science: a roadmap for biogerontology - GeroScience
The field of ageing science has gone through remarkable progress in recent decades, yet many fundamental questions remain unanswered or unexplored. Here we present a curated list of 100 open problems ...
link.springer.com
November 11, 2025 at 9:12 AM
A list of 100 open problems about aging science is a good starter on where to direct some LLMs link.springer.com/article/10.1...
Chinese longevity popularity and research continues to make the news, now the NY times is covering it too www.nytimes.com/2025/11/08/w... keep an eye on Time Pie.
In China, the Dream of Outrunning Time
www.nytimes.com
November 11, 2025 at 9:09 AM
Chinese longevity popularity and research continues to make the news, now the NY times is covering it too www.nytimes.com/2025/11/08/w... keep an eye on Time Pie.
Blue light-Activate! Biopolymer at MIT sets up under blue light to stick tissue back together after surgery. news.mit.edu/2025/usherin... heal faster, reconstruct better, and now FDA approved.
Ushering in a new era of suture-free tissue reconstruction for better healing
MIT spinout Tissium offers surgeons a new solution for suture-free nerve repair. The company’s flexible, biocompatible polymers conform to surrounding tissues, attaching to them in order to repair tor...
news.mit.edu
November 11, 2025 at 9:06 AM
Blue light-Activate! Biopolymer at MIT sets up under blue light to stick tissue back together after surgery. news.mit.edu/2025/usherin... heal faster, reconstruct better, and now FDA approved.
This Alzheimer's plaque reversal/memory restore in mice is back in the news again but why post it to LinkedIn? Isn't that just for jobs? www.linkedin.com/posts/rezahg... When can humans get the nanoparticles? Repair the BBB, fix the blood vessels.
Scientists just reversed Alzheimer's in mice using nanoparticles.
Not by delivering drugs. The nanoparticles themselves were the treatment.
Here's what happened:
Researchers designed bioacti...
Scientists just reversed Alzheimer's in mice using nanoparticles.
Not by delivering drugs. The nanoparticles themselves were the treatment.
Here's what happened:
Researchers designed bioactive nanop...
www.linkedin.com
November 11, 2025 at 7:39 AM
This Alzheimer's plaque reversal/memory restore in mice is back in the news again but why post it to LinkedIn? Isn't that just for jobs? www.linkedin.com/posts/rezahg... When can humans get the nanoparticles? Repair the BBB, fix the blood vessels.
FDA Clears Roche's Elecsys PTAU181 Alzheimers test on Nov. 4th of this year. (Cutting edge recent news!) It's going to LabCorp so that people can get peace of mind as the test rules the disease OUT with 97.9% reliability.
November 11, 2025 at 7:22 AM
FDA Clears Roche's Elecsys PTAU181 Alzheimers test on Nov. 4th of this year. (Cutting edge recent news!) It's going to LabCorp so that people can get peace of mind as the test rules the disease OUT with 97.9% reliability.
Protective microglia are brain cells that can help stand up to Alzheimer's, it has been discovered at Mt Sinai. www.sciencedaily.com/releases/202... the new task is figuring out how to boost them into doing a better job.
Scientists find brain cells that could stop Alzheimer’s
Researchers have identified special immune cells in the brain that help slow Alzheimer’s. These microglia work to reduce inflammation and block the spread of harmful proteins. They appear to protect m...
www.sciencedaily.com
November 10, 2025 at 9:34 AM
Protective microglia are brain cells that can help stand up to Alzheimer's, it has been discovered at Mt Sinai. www.sciencedaily.com/releases/202... the new task is figuring out how to boost them into doing a better job.
PCC1 is in the news because now China has got a hold of it for longevity. (Derived from grape seed components, helps destroy senescent cells) They're all over Twitter because they're adapting it to humans now. (so, good news for everybody if this works)
November 10, 2025 at 9:32 AM
PCC1 is in the news because now China has got a hold of it for longevity. (Derived from grape seed components, helps destroy senescent cells) They're all over Twitter because they're adapting it to humans now. (so, good news for everybody if this works)
Alzheimer's disrupts beyond the brain: So the cure or key to defeating it may be body-wide as well newatlas.com/brain/alzhei...
Alzheimer's impact on body fat explains its effects beyond the brain
A new study has revealed that Alzheimer's disease breaks apart nerves and blood vessels in fat tissue throughout the body. The finding could help explain the disease's ravages beyond mental impairment...
newatlas.com
November 9, 2025 at 10:25 AM
Alzheimer's disrupts beyond the brain: So the cure or key to defeating it may be body-wide as well newatlas.com/brain/alzhei...
Any time some giant corp or rich person decides to invest in big health tech (even if people don't like them/it!) it's good news, so here goes Zuckerberg's new video x.com/disclosetv/s... It doesn't matter where a cure comes from, it just matters that it COMES.
Disclose.tv on X: "NEW - Zuckerberg and his wife expand their existing Biohub initiative with AI-powered biology to cure or prevent disease, "The next decade is going to be really exciting, and we think that some of humanity's biggest dreams are finally coming within reach." https://t.co/yEHaGK0MY3" / X
NEW - Zuckerberg and his wife expand their existing Biohub initiative with AI-powered biology to cure or prevent disease, "The next decade is going to be really exciting, and we think that some of humanity's biggest dreams are finally coming within reach." https://t.co/yEHaGK0MY3
x.com
November 9, 2025 at 8:27 AM
Any time some giant corp or rich person decides to invest in big health tech (even if people don't like them/it!) it's good news, so here goes Zuckerberg's new video x.com/disclosetv/s... It doesn't matter where a cure comes from, it just matters that it COMES.