Chuan Wang
@chuanwangfdu.bsky.social
Associate professor @ Department of Medical Microbiology, Shanghai Medical College, Fudan University, China
RIL-seq revealing sRNA-mediated phage-host dialogue! What a cool finding. Big congrats on the Molecular Cell paper!
Do viruses use RNA to rewire bacteria?
Yes!
In our paper in @cp-molcell.bsky.social RIL-seq reveals interkingdom RNA interactions during λ infection. Phages don’t just encode proteins, they use small RNAs to hijack bacterial replication and fine-tune infection.
#RNA #Phage
doi.org/10.1016/j.mo...
Yes!
In our paper in @cp-molcell.bsky.social RIL-seq reveals interkingdom RNA interactions during λ infection. Phages don’t just encode proteins, they use small RNAs to hijack bacterial replication and fine-tune infection.
#RNA #Phage
doi.org/10.1016/j.mo...
Phage-encoded small RNA hijacks host replication machinery to support the phage lytic cycle
Using RIL-seq, Silverman et al. map the RNA interactome of E. coli during phage lambda
infection and uncover a conserved phage-encoded sRNA that activates host replication
machinery. Their findings re...
www.cell.com
December 19, 2025 at 12:35 PM
RIL-seq revealing sRNA-mediated phage-host dialogue! What a cool finding. Big congrats on the Molecular Cell paper!
How does a bacterial small RNA evolve new functions?
Our new study reveals the stepwise evolutionary journey of UhpU, a 3′UTR-derived sRNA in E. coli and relatives. It evolved from a metabolically-focused regulator to one with expanded targets and biogenesis manner.
www.pnas.org/doi/10.1073/...
Our new study reveals the stepwise evolutionary journey of UhpU, a 3′UTR-derived sRNA in E. coli and relatives. It evolved from a metabolically-focused regulator to one with expanded targets and biogenesis manner.
www.pnas.org/doi/10.1073/...
December 4, 2025 at 7:50 PM
How does a bacterial small RNA evolve new functions?
Our new study reveals the stepwise evolutionary journey of UhpU, a 3′UTR-derived sRNA in E. coli and relatives. It evolved from a metabolically-focused regulator to one with expanded targets and biogenesis manner.
www.pnas.org/doi/10.1073/...
Our new study reveals the stepwise evolutionary journey of UhpU, a 3′UTR-derived sRNA in E. coli and relatives. It evolved from a metabolically-focused regulator to one with expanded targets and biogenesis manner.
www.pnas.org/doi/10.1073/...
Learning medical microbiology starts with Gram staining. 🔬 #Microbiology #MedStudent
May 14, 2025 at 12:31 PM
Learning medical microbiology starts with Gram staining. 🔬 #Microbiology #MedStudent
Happy Chinese New Year！
January 28, 2025 at 11:52 AM
Happy Chinese New Year！
Happy to share our latest work published in @pnas.org In collaboration with @yjchao.bsky.social , we uncovered an RNase III-processed sRNA, ManS, that orchestrates sialic acid metabolism in Salmonella enterica during gut colonization.
Link: doi.org/10.1073/pnas...
Link: doi.org/10.1073/pnas...
January 11, 2025 at 10:54 AM
Happy to share our latest work published in @pnas.org In collaboration with @yjchao.bsky.social , we uncovered an RNase III-processed sRNA, ManS, that orchestrates sialic acid metabolism in Salmonella enterica during gut colonization.
Link: doi.org/10.1073/pnas...
Link: doi.org/10.1073/pnas...