Gavin Williams
@chemsynthbiol.bsky.social
Professor and Department Head of Chemistry at NC State. Natural products synthetic biology. Husband. Father. Liverpool Football Club fan.
Excited to share our #polyketide #biosensor artwork featured on the cover of Biochemistry! Thanks to several group members for your help with this! #MyACSCover
April 18, 2025 at 2:17 PM
Excited to share our #polyketide #biosensor artwork featured on the cover of Biochemistry! Thanks to several group members for your help with this! #MyACSCover
Thrilled to share our latest enzyme engineering in ACS Chemical Biology! We improved an enzyme involved in #polyketide starter unit biosynthesis and used it to generate polyketide acceptor substrates in vitro. Kudos to Jared and the team of authors! @pubs.acs.org
April 4, 2025 at 8:07 PM
Thrilled to share our latest enzyme engineering in ACS Chemical Biology! We improved an enzyme involved in #polyketide starter unit biosynthesis and used it to generate polyketide acceptor substrates in vitro. Kudos to Jared and the team of authors! @pubs.acs.org
Excited to share our @pubs.acs.org Syn Bio publication on the production of non-natural alkylated Trp derivatives in E. coli. Potential applications for #terpene diversification. Kudos to everyone who contributed to this work.
March 26, 2025 at 2:28 PM
Excited to share our @pubs.acs.org Syn Bio publication on the production of non-natural alkylated Trp derivatives in E. coli. Potential applications for #terpene diversification. Kudos to everyone who contributed to this work.
I am thrilled to share our latest biosensor publication in ACS Biochemistry. In this work, we engineered a #biosensor strain for detecting polyketide macrolactones as a step toward applying high-throughput #synbio to polyketide synthases. pubs.acs.org/doi/10.1021/... @ncstatechem.bsky.social
Directed Evolution of a Macrolide-Sensing Transcription Factor Biosensor for the Detection of Macrolactone Aglycones via “Effector Walking” and Efflux Pump Deletion
Glycosylated macrolactones (macrolides) often display broad and potent biological activities and are targets for drug development and discovery. The modular genetic organization of macrolide polyketid...
pubs.acs.org
March 19, 2025 at 6:39 PM
I am thrilled to share our latest biosensor publication in ACS Biochemistry. In this work, we engineered a #biosensor strain for detecting polyketide macrolactones as a step toward applying high-throughput #synbio to polyketide synthases. pubs.acs.org/doi/10.1021/... @ncstatechem.bsky.social