Centre of Excellence for Long-acting Therapeutics
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celtliverpool.bsky.social
Centre of Excellence for Long-acting Therapeutics
@celtliverpool.bsky.social
42 followers 99 following 90 posts
The Centre of Excellence for Long-acting Therapeutics (CELT) at #livuni is accelerating understanding of #longacting medicines, by combining world leading expertise in pharmacology and materials chemistry to create new interventions.
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celtliverpool.bsky.social
Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · Aug 4
Ever wondered what the Centre of Excellence for Long-acting Therapeutics (CELT) do?

We identify existing medications we know work and are safe, and create long-acting options. We execute materials chemistry and preclinical pharmacology research.

Find out more:
www.liverpool.ac.uk/centre-of-ex...
A scientist is working in a fume hood
celtliverpool.bsky.social
This #WorldDiabetesDay, our global long-acting therapeutics news:

💉 ADOCIA: once a month diabetes injection
🔬 SanegeneBio and Innovent: six-monthly hypertension injection
🫀 Rona Therapeutics: reduce ApoC3 and triglycerides

Read more:
www.liverpool.ac.uk/centre-of-ex...
insulin pen, diabetic measurement tools and pills on orange background
November 14, 2025 at 12:39 PM
celtliverpool.bsky.social
A video of our October Community of Practice session is live.

Laxman Cherkupally from @mmv.org delivered the session titled 'Considerations for long-acting injectable microsuspension development - Lessons from an anti-malarial therapy'

Watch here: youtu.be/3PTuh4sfA4g
A flyer with a circle of hands that reads "22/10/25. Community of Practice for long-acting therapeutics in maternal and paediatric health. Webinar: Considerations for long-acting injectable microsuspensions development - Lessons from an anti-malarial therapy."
November 13, 2025 at 12:17 PM
celtliverpool.bsky.social
Calling Clinical Pharmacologists!
Are you keen to make data from published studies count beyond the paper?

PKRxiv is a managed open-access repository and visualization platform for collaborative sharing of anonymised, PK data and associated covariates.
www.liverpool.ac.uk/centre-of-ex...
November 11, 2025 at 12:27 PM
Reposted by Centre of Excellence for Long-acting Therapeutics
pharmaforkids.bsky.social
Exciting meeting about new hub for long acting therapeutics today

@celtliverpool.bsky.social
@liverpooluni.bsky.social
November 6, 2025 at 10:04 AM
celtliverpool.bsky.social
Despite coming up to the end of 2025, we still have events, including 'Securing the future: Shaping the UK strategy on long-acting therapeutics' we're hosting for HALo tomorrow.

Find the other events we're hosting or presenting at on our Events Page: www.liverpool.ac.uk/centre-of-ex...
celtliverpool.bsky.social Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · 18d
'Securing the future: Shaping the UK strategy on long-acting therapeutics' is the first event of the UK Hub for Advanced Long-acting Therapeutics (HALo).

📆 Thursday 6 November 2025
⏰ 10am-4pm
🌍 Liverpool, UK

Find the agenda and how to register: www.liverpool.ac.uk/centre-of-ex...
@ukri.org
An image showing the speakers for the HALo launch. They are: Professor Steve Rannard (HALo), Susan Cole (MHRA), Dr Inti Qurashi (NHS / M-RIC), Dr Christian Seiler (Viiv), Ian Lafferty (Upperton), Henry Dunne (MNS)
November 5, 2025 at 12:05 PM
celtliverpool.bsky.social
Managed by @medicinespatentpool.org, LAPaL is a public database providing data on long-acting therapeutics and drug delivery technologies
This month's updates:
Long-acting semaglutide - updated global reg status and clinical trials
Lenacapavir - updated reg status
www.liverpool.ac.uk/centre-of-ex...
The LAPaL logo is the word LAPaL with 'the long-acting therapeutics patents and licences database' underneath.
October 30, 2025 at 3:03 PM
celtliverpool.bsky.social
29 October is @unesco.org's #WorldCodingDay.

It might not be clear how programming helps our goals to save patient lives through long-acting therapeutics, but it's actually a key part of our work.

Find out how in our blog piece:
www.liverpool.ac.uk/centre-of-ex...
Dr Rajith Rajoli is working on some CELT modelling. The blog title is written over the top "Lost on your coding journey? Our pharmacology researchers can help".
October 29, 2025 at 12:31 PM
celtliverpool.bsky.social
'Securing the future: Shaping the UK strategy on long-acting therapeutics' is the first event of the UK Hub for Advanced Long-acting Therapeutics (HALo).

📆 Thursday 6 November 2025
⏰ 10am-4pm
🌍 Liverpool, UK

Find the agenda and how to register: www.liverpool.ac.uk/centre-of-ex...
@ukri.org
An image showing the speakers for the HALo launch. They are: Professor Steve Rannard (HALo), Susan Cole (MHRA), Dr Inti Qurashi (NHS / M-RIC), Dr Christian Seiler (Viiv), Ian Lafferty (Upperton), Henry Dunne (MNS)
October 28, 2025 at 2:13 PM
celtliverpool.bsky.social
Exciting recent long-acting news from other teams includes:

@nhsengland.bsky.social roll out cabotegravir, two monthly HIV PrEP
ViiV show cabotegravir is more acceptable than lenacapavir
FDA approved @tevapharm.bsky.social UZEDY for bipolar I disorder

www.liverpool.ac.uk/centre-of-ex...
A person is reading the news on their tablet
October 24, 2025 at 2:31 PM
celtliverpool.bsky.social
Are you subscribed to our quarterly #LONGEVITYproject newsletter?

We update LONGEVITY news, opportunities and global events.
LONGEVITY, funded by @unitaid.bsky.social, is working to create long-acting malaria, TB and HCV medicines for patients in LMICs.

Sign up: www.liverpool.ac.uk/centre-of-ex...
An illustration of a globe with items leading away from it, they read "materials chemistry + pharmacology + regulatory expertise + community engagement = new long-acting medicines"
October 23, 2025 at 11:53 AM
celtliverpool.bsky.social
Have you used Teoreler for any research that has since been published?

If so, we'd like to add you to the list of publications Teoreler was used for: www.liverpool.ac.uk/centre-of-ex...

Email us on askcelt@liverpool.ac.uk
Dr Rajith Rajoli is using modelling software on their computer. Over the image reads "Teoreler: A web-based physiologically based pharmacokinetic (PBPK) modelling application for the simulation and extrapolation of drug use scenarios. This application simulates drug pharmacokinetics of small molecules using complex mathematical equations to predict the efficacy of drugs in the human body in a variety of species and populations."
October 22, 2025 at 11:50 AM
celtliverpool.bsky.social
Our webinar is tomorrow (22 October) at 12pm (BST/GMT+1).

Guest speaker Laxman Cherkupally, from @mmv.org, will present 'Considerations for long-acting injectable microsuspension development - Lessons from an anti-malarial therapy. V2'.

Find out how to register: www.liverpool.ac.uk/centre-of-ex...
celtliverpool.bsky.social Centre of Excellence for Long-acting Therapeutics @celtliverpool.bsky.social · Oct 7
This #ChildHealthDay we're highlighting our upcoming Community of Practice webinar, hosted by Laxman Cherkupally from @mmv.org on 22 October.

The majority of malaria deaths are children under 5 years old. All malaria work is to protect children health.
events.teams.microsoft.com/event/8ad398...
October 21, 2025 at 12:41 PM
celtliverpool.bsky.social
We were pleased to be part of this research with Bicycle Therapeutics and its brilliant findings.

www.biorxiv.org/content/10.1...
Investigation of anti-SARS CoV-2 multimeric bicyclic peptide inhibitors in a range of pre-clinical therapeutic settings
The spread of respiratory viruses, such as Influenza and SARS-CoV-2 has presented significant challenges over the last 30 years with few effective therapeutic options available to this day. Bi-cyclic ...
www.biorxiv.org
October 15, 2025 at 11:06 AM
celtliverpool.bsky.social
Dr Cameron Hogarth leads our Manufacturing Capability project, aiming to create an open-access resource of manufacturers' long-acting capabilities in LMICs.

Connecting to organisations is a powerful way to find necessary data.

Read more: www.liverpool.ac.uk/centre-of-ex...
@unitaid.bsky.social
Dr Hogarth is standing outside the conference entrance under a banner that reads "Welcome to AHMTEC 2025"
October 14, 2025 at 11:53 AM
Reposted by Centre of Excellence for Long-acting Therapeutics
academicmededu.bsky.social
#Throwback to last month’s 26th #ANTIVIRALPK workshop!

We explored new insights on #rifamycins and #antiretrovirals, to pharmacologic considerations for #HIV prevention (#PEP & #PrEP), and the latest on long-acting ART (LA CAB/RPV).

🔗Enduring materials: amededu.co/4hTUPgN

#IDSky #MedSky #HIVSky
October 8, 2025 at 2:28 PM
celtliverpool.bsky.social
This #ChildHealthDay we're highlighting our upcoming Community of Practice webinar, hosted by Laxman Cherkupally from @mmv.org on 22 October.

The majority of malaria deaths are children under 5 years old. All malaria work is to protect children health.
events.teams.microsoft.com/event/8ad398...
October 7, 2025 at 11:33 AM
celtliverpool.bsky.social
#ManufacturingDay is the last Thursday of September (UK - @makeuk.bsky.social) and the first Friday of October (US)

We're leading the Manufacturing Capability project to create an open resource to show manufacturing capabilities in LMICs:
www.liverpool.ac.uk/centre-of-ex...
@unitaid.bsky.social
a global heat map with pins has the blog title written over the top: We're a preclinical team with a focus on manufacturing capability - Here's why.
October 3, 2025 at 11:17 AM
celtliverpool.bsky.social
9 October, CELT's Prajith Venkatasubramanian is delivering a webinar with Dr Leena Zino.

They'll discuss long acting drug delivery systems and the patents / regulatory process.

Find out more about this and other events CELT are at via our event page:
www.liverpool.ac.uk/centre-of-ex...
The event title is at the top with pictures of Prajith Venkatasubramanian and Leena Zino with event times underneath them.
October 2, 2025 at 2:35 PM
celtliverpool.bsky.social
The Systems Medicine team have published: Physiologically based pharmacokinetic modelling of serum 25-hydroxyvitamin D concentrations in schoolchildren receiving weekly oral vitamin D3 supplementation

Find a link to the full article and other CELT publications: www.liverpool.ac.uk/centre-of-ex...
A close up image of a vitamin d capsule on a yellow background
October 1, 2025 at 11:35 AM
celtliverpool.bsky.social
Teoreler is a free online PBPK modelling application. With support from @unitaid.bsky.social, our team work really hard to continually update Teoreler and add new models.

Find out more if you're new to Teoreler, or leave us feedback if you're not, via the link: www.liverpool.ac.uk/centre-of-ex...
Dr Rajith Rajoli is using modelling software on their computer. Over the image reads "Teoreler: A web-based physiologically based pharmacokinetic (PBPK) modelling application for the simulation and extrapolation of drug use scenarios. This application simulates drug pharmacokinetics of small molecules using complex mathematical equations to predict the efficacy of drugs in the human body in a variety of species and populations."
September 30, 2025 at 11:02 AM
celtliverpool.bsky.social
28 September was @unesco.org's International Day for Universal Access to Information.

We've told you why we think patients accessing research that represents them is important. Now we can show you how we're doing it.

www.liverpool.ac.uk/centre-of-ex...
#AccessToInfo #AccessToInfoDay #RightToKnow
a group of people are sat in a circle, the text is the blog title "Access to information is mission critical – here’s why and how we’re doing it"
September 29, 2025 at 2:08 PM
celtliverpool.bsky.social
News from other long-acting teams:

- @unitaid.bsky.social, Clinton Health Access Initiative and Wits RHI: agreement with Dr Reddy's Laboratories to make affordable lenacapavir
- @unaids.org respond to the announcement of making affordable HIV preventatives.

www.liverpool.ac.uk/centre-of-ex...
A person is holding a vial of lenacapavir
September 26, 2025 at 11:26 AM
celtliverpool.bsky.social
Next week is our quarterly #LONGEVITYproject newsletter.

This quarter includes:
- Work from partners @treatmentactiongroup.org and CHAI.
- Recent hepatitis C virus proof of concept news
- Community of Practice meeting highlights.

Subscribe: www.liverpool.ac.uk/centre-of-ex...
@unitaid.bsky.social
A woman looks into the sunrise over a beautiful landscape. The text reads "LONGEVITY Project: Aiming to reduce the burden of disease in low- and middle- income countries"
September 24, 2025 at 12:23 PM
celtliverpool.bsky.social
Last week's Global News updates from other long-acting therapeutics teams covered:

💉Oruka Therapeutics announced positive interim phase 1 results for long-acting plaque psoriasis treatment.

Find this and other stories on our Global News page: www.liverpool.ac.uk/centre-of-ex...
A syringe is being filled from a vial
September 22, 2025 at 1:50 PM
celtliverpool.bsky.social
We're hosting ARIA's visit to @liverpooluni.bsky.social, with an introduction from our co-Director Prof. Andrew Owen.

ARIA's Brian Wang will dive into the newly launched programme thesis, Sustained Viral Resilience.

📆 Friday 26 September 2025
🌍 The Victoria Gallery and Museum, Liverpool UK.
thepandemicinst.bsky.social The Pandemic Institute @thepandemicinst.bsky.social · Sep 3
Our colleagues @celtliverpool.bsky.social will be hosting ARIA in Liverpool on Sept 26th, 1 PM - 2:30 PM, to hear about their newly launched programme thesis, Sustained Viral Resilience.

To find out more and register:
www.eventbrite.co.uk/e/aria-visit...
ARIA Visit to UoL
Join ARIA's team on September 26th for a session to hear about their newly launched programme thesis, Sustained Viral Resilience.
www.eventbrite.co.uk
September 18, 2025 at 11:21 AM