Sebastian Castillo-Hair
@castillohair.bsky.social
Postdoctoral researcher at the University of Washington, working on AI + Synthetic Biology
Pinned
Programming human cell type-specific gene expression via an atlas of AI-designed enhancers
Differentially active enhancers are key drivers of cell type specific gene expression. Active enhancers are found in open chromatin, which can be mapped at genome scale across tissue and cell types. T...
www.biorxiv.org
🚀Excited to share our new preprint: “Programming human cell type-specific gene expression via an atlas of AI-designed enhancers”
We built the largest repository of AI-designed enhancers, validated across 10 human cell lines + mouse retina.
👉 www.biorxiv.org/content/10.1...
#AI #Genomics #SynBio
We built the largest repository of AI-designed enhancers, validated across 10 human cell lines + mouse retina.
👉 www.biorxiv.org/content/10.1...
#AI #Genomics #SynBio
🚀Excited to share our new preprint: “Programming human cell type-specific gene expression via an atlas of AI-designed enhancers”
We built the largest repository of AI-designed enhancers, validated across 10 human cell lines + mouse retina.
👉 www.biorxiv.org/content/10.1...
#AI #Genomics #SynBio
We built the largest repository of AI-designed enhancers, validated across 10 human cell lines + mouse retina.
👉 www.biorxiv.org/content/10.1...
#AI #Genomics #SynBio
Programming human cell type-specific gene expression via an atlas of AI-designed enhancers
Differentially active enhancers are key drivers of cell type specific gene expression. Active enhancers are found in open chromatin, which can be mapped at genome scale across tissue and cell types. T...
www.biorxiv.org
October 6, 2025 at 4:57 PM
🚀Excited to share our new preprint: “Programming human cell type-specific gene expression via an atlas of AI-designed enhancers”
We built the largest repository of AI-designed enhancers, validated across 10 human cell lines + mouse retina.
👉 www.biorxiv.org/content/10.1...
#AI #Genomics #SynBio
We built the largest repository of AI-designed enhancers, validated across 10 human cell lines + mouse retina.
👉 www.biorxiv.org/content/10.1...
#AI #Genomics #SynBio
Reposted by Sebastian Castillo-Hair
Programming human cell type-specific gene expression via an atlas of AI-designed enhancers https://www.biorxiv.org/content/10.1101/2025.09.30.679565v1
October 1, 2025 at 4:09 AM
Programming human cell type-specific gene expression via an atlas of AI-designed enhancers https://www.biorxiv.org/content/10.1101/2025.09.30.679565v1
Reposted by Sebastian Castillo-Hair
New paper out in @cp-cellsystems.bsky.social in collaboration with the lab of Georg Seelig at UW, and led by the awesome Chris Yin and @castillohair.bsky.social
Using a variety of deep-learning models, we design synthetic enhancer elements:
Using a variety of deep-learning models, we design synthetic enhancer elements:
June 19, 2025 at 2:24 PM
New paper out in @cp-cellsystems.bsky.social in collaboration with the lab of Georg Seelig at UW, and led by the awesome Chris Yin and @castillohair.bsky.social
Using a variety of deep-learning models, we design synthetic enhancer elements:
Using a variety of deep-learning models, we design synthetic enhancer elements: