The Castiglione Lab @ Vanderbilt
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castiglionelab.bsky.social
The Castiglione Lab @ Vanderbilt
@castiglionelab.bsky.social
Assistant Professor, Biological Sciences, Ophthalmology & Visual Sciences|
Genomics, biochemistry, evolution|
www.castiglionelab.com
Pinned
Our newest paper is out in Science! This riddle took 5 years to solve. Genome annotation and AI missed it. Manual inspection and serendipity still have advantages for cracking nature's secrets! With @science.org @evolutionvu.bsky.social @rokaslab.bsky.social

www.science.org/doi/10.1126/...
Running a genetic stop sign accelerates oxygen metabolism and energy production in horses
Horses are among nature’s greatest athletes, yet the ancestral molecular adaptations fueling their energy demands are poorly understood. Within a clinically important pathway regulating redox and meta...
www.science.org
Reposted by The Castiglione Lab @ Vanderbilt
Scientists are using ancient works of art to piece together a critically endangered species’ past.
Ancient poems document the decline of the Yangtze finless porpoise
The porpoise is critically endangered. Ancient Chinese poems reveal the animal’s range has dropped about 65 percent over the past 1,400 years.
buff.ly
May 7, 2025 at 10:01 PM
Reposted by The Castiglione Lab @ Vanderbilt
If you're a grad student or an undergrad interested in research I need to you listen to me very carefully.

You cannot learn to write good research papers if you do not read good research papers.

Stop asking LLMs to summarize papers for you.
May 3, 2025 at 8:25 PM
Thrilled to be featured on the BBC! (21:25)
www.bbc.co.uk/sounds/play/... @science.org
March 29, 2025 at 10:37 PM
Our newest paper is out in Science! This riddle took 5 years to solve. Genome annotation and AI missed it. Manual inspection and serendipity still have advantages for cracking nature's secrets! With @science.org @evolutionvu.bsky.social @rokaslab.bsky.social

www.science.org/doi/10.1126/...
Running a genetic stop sign accelerates oxygen metabolism and energy production in horses
Horses are among nature’s greatest athletes, yet the ancestral molecular adaptations fueling their energy demands are poorly understood. Within a clinically important pathway regulating redox and meta...
www.science.org
March 28, 2025 at 12:27 AM
Reposted by The Castiglione Lab @ Vanderbilt
🏇 Horses evolved a viral trick to outrun damage.
@castiglionelab.bsky.social found a rare mutation that supercharges muscle energy—without the usual side effects.
New study out in Science. Read our press release >> loom.ly/FUbYSu0

🔬 #evolution #genetics #Science2025
March 27, 2025 at 6:34 PM