Carla Abreu
@carlamcabreu.bsky.social
Team leader @i3S_UPorto, passionate about animal development and congenital disease mechanisms, with a particular focus on germline and neuro development. Enthusiast of ciliary molecular motors and cilia-mediated signaling.
Can #cilia grow without #dynein-2 mediated retrograde #IFT?👀
Yes, they can! Removing the ciliary gate lets trapped IFT components escape via diffusion & ciliary #EVs, driving axoneme elongation.
👉 doi.org/10.1101/2025...
🧬 Work led with @dantas-lab.bsky.social, in collaboration with Peterman lab.
Yes, they can! Removing the ciliary gate lets trapped IFT components escape via diffusion & ciliary #EVs, driving axoneme elongation.
👉 doi.org/10.1101/2025...
🧬 Work led with @dantas-lab.bsky.social, in collaboration with Peterman lab.
Removal of the Ciliary Gate Allows Axoneme Extension in the Absence of Retrograde IFT
The transition zone (TZ) is a selective barrier that maintains ciliary compartmentalization by controlling protein entry and exit. Cilia assembly requires the crossing of this barrier by intraflagella...
doi.org
October 28, 2025 at 11:39 AM
Can #cilia grow without #dynein-2 mediated retrograde #IFT?👀
Yes, they can! Removing the ciliary gate lets trapped IFT components escape via diffusion & ciliary #EVs, driving axoneme elongation.
👉 doi.org/10.1101/2025...
🧬 Work led with @dantas-lab.bsky.social, in collaboration with Peterman lab.
Yes, they can! Removing the ciliary gate lets trapped IFT components escape via diffusion & ciliary #EVs, driving axoneme elongation.
👉 doi.org/10.1101/2025...
🧬 Work led with @dantas-lab.bsky.social, in collaboration with Peterman lab.