Protein complexes with higher disorder are less sensitive to molecular chirality, compared to folded complexes. We now show that the translocation carrier Importin α3 is highly tolerant of the stereochemistry of nuclear localization signals in both folded proteins and IDPs.
doi.org/10.3390/ijms...

Scientific journals are complaining that they are having a harder time finding reviewers. Yet, I just found out that I set my new personal record by serving as one of EIGHT reviewers for a manuscript. That seems like a lot!

We expanded the chemical space of inhibitors of intrinsically disordered proteins to include silicon compounds. Affinities measured in vitro are not very high, but simulations demonstrate a well-defined binding mechanism. Thus, we have ideas on how to improve these molecules.
doi.org/10.1016/j.ab...

Italy's largest research organization (#CNR) has been left without a President – and no one knows why. The previous President's term has expired, yet the process of appointing a new one has not even started. Most of the Board of Directors' terms have also expired, so we are now close to a paralysis.

Citrullination is a post-translational modification that is critical for many physiological processes. We combined experiments and simulations on disordered peptides to identify the citrullination sites of MDM2, an IDP that acts as a key regulator of the tumor suppressor p53.
doi.org/10.1002/pro....

The 2025 Congress of the European Biophysical Societies' Association #EBSA will be held in Rome (Italy) from June 30 to July 4, 2025. The website is rapidly being updated, and the program includes 28 parallel symposia.
www.ebsa2025.eu/program

Drug design against a 100% disordered protein is challenging. Our latest effort combined high-throughput screening with remodeling of the lead compound. The resulting drug candidate reduced tumor growth in a xenograft mouse model of human pancreatic cancer.
nature.com/articles/s41598-024-79340-z