We’re told to minimize conformational strain—but what if it’s not always the enemy?

Strain can improve specificity, pre-organize molecules, or enable stronger interactions. The key is using it strategically.

💬 Have you ever leveraged strain in your designs?

#DrugDesign #Innovation

I assumed a single conformational search would find the true global minimum.

The result? Incomplete data, higher strain estimates, and missed opportunities.

Iterative searches revealed more accurate minima, refining outcomes.

💬 Have you faced similar challenges?

#DrugDesign #Innovation

Conformational strain is becoming a must-know in drug design. With advancing tools, strain optimization will soon be standard, reducing failures, boosting accuracy, and accelerating timelines.

💬 Are you integrating strain analysis, or is it your next big leap?

#DrugDesign #Innovation

Conformational strain is the hidden challenge in drug design. Reducing it improves binding, stability, and development timelines.

It’s not as complex as it seems—quantifying strain unlocks smarter design and better outcomes.

💬 How do you approach it in your work?

#DrugDesign #Innovation #Pharma

Unlock the Hidden Challenge in Drug Design: Conformational Strain

This critical factor affects efficacy, stability, and timelines. I’ve broken it down step-by-step in a carousel.

👉 View it here: https://buff.ly/3W1gyur

#DrugDesign #Innovation #MedicinalChemistry