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brightgiant.bsky.social
Bright Giant
@brightgiant.bsky.social
We want to establish the identification of unknown small molecules:
Profound algorithms and state-of-the-art machine learning software solutions for small molecule mass spectrometry analysis.
https://bright-giant.com/
Pinned
🚀 SIRIUS v6.3 is here!
We're excited to introduce the latest version of #SIRIUS with powerful new features to enhance small molecule identification.

⬇️ Learn more and download SIRIUS v6.3 today:
bright-giant.com/sirius-relea...

#SIRIUS6 #MSsoftware #MassSpectrometry #SmallMoleculeIdentID
#SIRIUS6 in a #NonTargetedAnalysis to identify unknown chemical compounds with potential estrogenic activity to investigate the link between #DrinkingWater #contaminants and #BreastCancer incidence.

▶️ Try SIRIUS now: buff.ly/K8wQ3ER
💡 Original publication: buff.ly/SZ2LPbp

#SmallMoleculeID
November 13, 2025 at 8:29 AM
Untargeted #metabolomics using #SIRIUS6 is mapping the #InternationalSpaceStation
Most extensive look yet at the microbial and chemical landscape of the ISS.

💡 Blog post: buff.ly/nGt934u (5 min)
📄 Original publication: buff.ly/s8BBclb
▶️ Try #SIRIUS6 now: buff.ly/K8wQ3ER

#SIRIUSDiscoveries
November 11, 2025 at 8:52 AM
#SIRIUS6 compound class prediction helps to validate ethanol extraction for human faecal #metabolomics as a valid, safer, and more economical alternative to the common methanol extraction.

▶️ Try SIRIUS now: buff.ly/x7dNWAR
📄 Publication: buff.ly/cGkUOyi

#SIRIUSDiscoveries #Microbiome
November 6, 2025 at 8:48 AM
New study from the long-running @jena-experiment.bsky.social challenges core ecological assumption: that in a diverse ecosystem, plants can save energy on defenses and focus on growth.
📄 Blog feature: buff.ly/LgCEGpL
📄 Publication: buff.ly/u6lzwUe

#SIRIUS6 #SIRIUSDiscoveries #NonTargetedAnalysis
November 4, 2025 at 8:48 AM
#MultiOmics study revelead link between microbial community structure and chemical profile of the surface #metabolome in Saccharina latissima.

💡 Check out more SIRIUS discoveries: buff.ly/aI5m3ps
📄 Paper: buff.ly/uUT34E0

#SIRIUSDiscoveries #MarineBiology #Microbiology #ChemicalEcology
October 30, 2025 at 8:48 AM
Green solvents can effectively extract diverse bioactive compounds from Melissa officinalis leaves. SIRIUS was employed for the comprehensive annotation of metabolites, resulting in the putative annotation of 444 metabolites.

💡 More #SIRIUSDiscoveries: buff.ly/aI5m3ps
📄 Paper: buff.ly/AEpoIFv
October 28, 2025 at 8:52 AM
In this #NonTargetedAnalysis utilizing SIRIUS, researcher successfully identify common and previously unreported chemical contaminants in human milk, including novel parabens.

Blog post: buff.ly/0vQizvG
Paper: buff.ly/Mg8axQF

#SIRIUS6 #StructureElucidation
October 22, 2025 at 7:48 AM
Using SIRIUS, researcher identified anti-viral compounds in Caesalpinia mimosoides hydroethanolic extract that help to inhibit influenza A virus by targeting two critical viral proteins.

▶️ Try SIRIUS: buff.ly/x7dNWAR
💡 More SIRIUS discoveries: buff.ly/aI5m3ps
📄 Original publication: buff.ly/qR8zEvb
October 15, 2025 at 7:48 AM
New review on #MassSpectrometry-based #Metabolomics for #NaturalProductResearch positions #SIRIUS6 as the leading suite for molecular structure annotation.

▶️ Try SIRIUS now: buff.ly/x7dNWAR
📄 Read the full review: buff.ly/0mMyixO

#StructureElucidation #SmallMoleculeID #MachineLearning
October 8, 2025 at 7:48 AM
MCheM integrates online chemical labeling reactions directly into the LC-MS/MS workflow to provide structural information which is fed into #SIRIUS6 via @mzmine.bsky.social to significantly constrain the molecular structure search space and boost annotation accuracy.

Learn more: buff.ly/iib0L6I
October 1, 2025 at 7:48 AM
🧠 ✏️ Your chemical intuition, now integrated into #SIRIUS6.
Have you tried the new Structure Sketcher yet?
▶️ Watch our new YouTube tutorial to learn how to use the Structure Sketcher and elevate your annotation process: www.youtube.com/watch?v=_byB...

#HowToSIRIUS #SmallMoleculeID #MassSpec
September 24, 2025 at 7:23 AM
Do you ever look at the best hit from a structure database search and instantly know how to improve it?
In #SIRIUS6, your chemical intuition just got a powerful new tool: the Structure Sketcher.
buff.ly/c4cfGvW

#HowToSIRIUS #SmallMoleculeID
September 10, 2025 at 7:48 AM
🌍✨We're blown away by the growth of the SIRIUS community!

We're seeing unprecedented usage and impact of our software across the globe.

⬆️ 1.000.000.000+ processed queries
👥 1.500+ monthly active users

🙏 Thank you for being part of this journey. We're excited to see what you discover next!
September 3, 2025 at 7:48 AM
⚠️ Important Announcement for SIRIUS 5 Users! ⚠️
Maintenance and support for SIRIUS 5 will officially end on 🗓️ February 28, 2026.

To ensure you continue to benefit from the latest advancements, we highly recommend upgrading to #SIRIUS6: buff.ly/91GQKjH

#SIRIUSSoftware #SmallMoleculeAnnotation
August 27, 2025 at 7:48 AM
🚀 SIRIUS v6.3 is here!
We're excited to introduce the latest version of #SIRIUS with powerful new features to enhance small molecule identification.

⬇️ Learn more and download SIRIUS v6.3 today:
bright-giant.com/sirius-relea...

#SIRIUS6 #MSsoftware #MassSpectrometry #SmallMoleculeIdentID
August 20, 2025 at 7:48 AM
Test your #SIRIUS6 knowledge! 🧠

❓ The SIRIUS software uses an ILP solver to perform which specific task ❓
Drop a comment with your answer! The correct answer will be revealed on Friday.

Learn more about #SIRIUSSoftware: buff.ly/vBOiq3F

#SmallMoleculeID #StructureElucidation
August 18, 2025 at 7:28 AM
Times Are Changing, but Order Matters: The @boeckerlab.bsky.social has introduced a groundbreaking two-step method for transferable retention time prediction
buff.ly/vcFreLJ

#Chromatography #RetentionTime #MachineLearning #SmallMoleculeIdentification
August 14, 2025 at 9:55 AM
SIRIUS identifies potentially allergenic transformation products of tattoo pigments in new online-LC-EC-MS approach that overcomes the challenge of impure pigment standards by separating pigments from impurities before simulating their metabolism. #SmallMoleculeID #SIRIUS6 doi.org/10.1007/s002...
July 30, 2025 at 7:48 AM
🚨 Detecting deadly nitazenes just got easier. A new study uses untargeted LC-HRMS + #SIRIUS6 to ID key phase I/II metabolites, boosting opioid detection. Advanced #MSsoftware + #MachineLearning are shaping the future of #Toxicology. #DrugDiscovery #SIRIUSDiscoveries doi.org/10.3390/meta...
July 23, 2025 at 7:48 AM
🪸 New study reveals coral resilience may be inherited! Using LC-MS/MS + #SIRIUS, scientists found thermal tolerance compounds passed from parent to offspring in Montipora capitata. Biochemical “memory” could guide reef restoration in a warming world. 🪸 #CoralReef #Science

doi.org/10.1038/s414...
July 17, 2025 at 9:09 AM
The number of potential small molecules in #ChemicalSpace corresponds to the number of atoms in the observable universe. 🤯
But the real challenge isn’t just the scale — it’s the complexity. Molecules are graphs, not strings, making it impractical, if not impossible, to simply enumerate them all.
July 14, 2025 at 8:19 AM
🚀 Great turnout at our #SIRIUS6 workshop at #MetSoc2025. 80+ attendees & a lively Q&A! We showcased how SIRIUS goes beyond spectral libraries with structure generation & analog search. Missed it? Let’s connect at booth T11.
#MassSpectrometry #Metabolomics #AutomatedAnnotation
June 25, 2025 at 7:26 AM
More first-hand insights from the #SIRIUSCommunity on the third day of #MetSoc2025.

Don't miss the opportunity to get in touch!

#SIRIUS6 #MetaboliteAnnotation #SmallMoleculeID #MassSpectrometry #SIRIUSEvents
June 24, 2025 at 3:05 PM
Novel transformation product annotation with #SIRIUS6 - Don't miss this talk at #MetSoc2025 !

🎤 @mfleischauer.bsky.social
📅 June 25 | 4:30 p.m. – 4:50 p.m.
📍 Congress Hall | Abstract #471

#Metabolomics #LCMSMS #SmallMoleculeID #TransformationProducts #MassSpectrometry #StructureAnnotation
June 24, 2025 at 7:52 AM
🗓️ Plan your Tuesday: Gain first-hand 👌 SIRIUS insights at #MetSoc2025
Make sure to mark your calendars for these talks and posters from the #SIRIUSCommunity

#SIRIUS6 #MetaboliteAnnotation #SmallMoleculeID #MassSpectrometry #SIRIUSEvents
June 24, 2025 at 5:00 AM