Brewster Lab
@brewsterlab.bsky.social
Studying gene regulation at UMass Chan Medical School
Our NAR paper is officially out (doi.org/10.1093/nar/...). Digging in to how TFs work as a function of where they bind, what they bind to and which promoter they regulate on synthetic promoters designed to be regulated ONLY by that TF. Huge effort by both Sunil and Vinu.
A systematic survey of TF function in E. coli suggests RNAP stabilization is a prevalent strategy for both repressors and activators
Abstract. Transcription factors (TFs) are often classified as activators or repressors, yet these context-dependent labels are inadequate to predict quanti
doi.org
February 12, 2025 at 3:20 PM
Our NAR paper is officially out (doi.org/10.1093/nar/...). Digging in to how TFs work as a function of where they bind, what they bind to and which promoter they regulate on synthetic promoters designed to be regulated ONLY by that TF. Huge effort by both Sunil and Vinu.
How does a TFs function depend on the promoter it regulates? We know that a TF can have different effects on different promoters. For example, consider this case: CpxR regulates ldtCp, yccAp, efeUp at a similar location. Yet two of them are activated, one repressed #GeneReg 🧪 tinyurl.com/3hr9njnd
December 17, 2024 at 3:49 PM
How does a TFs function depend on the promoter it regulates? We know that a TF can have different effects on different promoters. For example, consider this case: CpxR regulates ldtCp, yccAp, efeUp at a similar location. Yet two of them are activated, one repressed #GeneReg 🧪 tinyurl.com/3hr9njnd