A huge thank you to Radwa Moanis, Hannelore Geeraert, Niko Van den Brande, Ulrich Hennecke, Stanislav Obruča, Iva Buchtíková, Karel Sedlář, Petr Sedláček — and of course, Eveline Peeters 😁 — for their expertise, insights, and invaluable contributions to this work!
A huge thank you to Radwa Moanis, Hannelore Geeraert, Niko Van den Brande, Ulrich Hennecke, Stanislav Obruča, Iva Buchtíková, Karel Sedlář, Petr Sedláček — and of course, Eveline Peeters 😁 — for their expertise, insights, and invaluable contributions to this work!
This opens exciting questions: How do their enzymes and granule structures cope with heat? Could they inspire heat-stable PHA production platforms?
Answering these could push the frontiers and enable next-gen bioplastic production under extreme conditions.
#Extremophiles #Bioplastics
This opens exciting questions: How do their enzymes and granule structures cope with heat? Could they inspire heat-stable PHA production platforms?
Answering these could push the frontiers and enable next-gen bioplastic production under extreme conditions.
#Extremophiles #Bioplastics
🧪 Limited energy yield in hot, often anaerobic environments?
🧬 Cytoplasmic crowding from PHA granules disrupts molecular diffusion?
💧 Higher risk of water loss and cytoplasmic dehydration?
🌡️ Thermal instability of amorphous PHA granules leads to aggregation or crystallization?
🧪 Limited energy yield in hot, often anaerobic environments?
🧬 Cytoplasmic crowding from PHA granules disrupts molecular diffusion?
💧 Higher risk of water loss and cytoplasmic dehydration?
🌡️ Thermal instability of amorphous PHA granules leads to aggregation or crystallization?
🙋 Why oh why is PHA accumulation such a common strategy in mesophiles and moderate thermophiles but not in extreme thermophiles?
🙋 Why oh why is PHA accumulation such a common strategy in mesophiles and moderate thermophiles but not in extreme thermophiles?
🔥🔥🔥 However, when looking at the genomes of extremely thermophilic microorganisms we found that PHA producers became MUCH scarcer. We couldn't find hits within the bacterial domain and found only a few hits in the archaeal domain belonging to Ferroglobus sp. Archaeoglobus sp. and Geoglobus sp.
🔥🔥🔥 However, when looking at the genomes of extremely thermophilic microorganisms we found that PHA producers became MUCH scarcer. We couldn't find hits within the bacterial domain and found only a few hits in the archaeal domain belonging to Ferroglobus sp. Archaeoglobus sp. and Geoglobus sp.
🔥 As confirmed in existing literature, we did find a lot of examples of moderately thermophilic microorganisms which can produce PHAs, both in the archaeal and the bacterial domain.
🔥 As confirmed in existing literature, we did find a lot of examples of moderately thermophilic microorganisms which can produce PHAs, both in the archaeal and the bacterial domain.
⁉️What did we do --> We built a bioinformatics pipeline to scan thermophilic genomes for phaC, the key gene for bioplastic production.
⁉️What did we do --> We built a bioinformatics pipeline to scan thermophilic genomes for phaC, the key gene for bioplastic production.
🔥🔥🔥 However, when looking at the genomes of extremely thermophilic microorganisms we found that PHA producers became MUCH scarcer. We couldn't find hits within the bacterial domain and found only a few hits in the archaeal domain belonging to Ferroglobus sp. Archaeoglobus sp. and Geoglobus sp.
🔥🔥🔥 However, when looking at the genomes of extremely thermophilic microorganisms we found that PHA producers became MUCH scarcer. We couldn't find hits within the bacterial domain and found only a few hits in the archaeal domain belonging to Ferroglobus sp. Archaeoglobus sp. and Geoglobus sp.
🔥 As confirmed in existing literature, we did find a lot of examples of moderately thermophilic microorganisms which can produce PHAs, both in the archaeal and the bacterial domain.
🔥 As confirmed in existing literature, we did find a lot of examples of moderately thermophilic microorganisms which can produce PHAs, both in the archaeal and the bacterial domain.