Brandi M. Wynne, MS PhD FAHA
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brandimwynne.bsky.social
Brandi M. Wynne, MS PhD FAHA
@brandimwynne.bsky.social
3K followers 1.3K following 130 posts
Previously tweeter @brandimwynne

Asst Prof/cardiorenal phys&pharm/@KidneyInCVD/@HyperAHA/@ASPET/@UofUNephrology/#FAHA/#hypertension/#travel /☕️/#foodie Tweets=my own
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Reposted by Brandi M. Wynne, MS PhD FAHA
amjhypertension.bsky.social
#WeekendReads from the Archives

Pro-neurotensin/Neuromedin N and Hypertension Risk: A Prospective Study

academic.oup.com/ajh/article/...

#Free
Pro-neurotensin/Neuromedin N and Hypertension Risk: A Prospective Study
AbstractBackground. Neurotensin, a neuropeptide with direct cardiac effects, has been associated with prospective risk of hypertension-related conditions t
academic.oup.com
November 16, 2025 at 1:15 PM
Reposted by Brandi M. Wynne, MS PhD FAHA
amjhypertension.bsky.social
The November issue is online!

academic.oup.com/ajh/issue/38...

Reviews, commentaries and lots of original reasearch!
Volume 38 Issue 11 | American Journal of Hypertension | Oxford Academic
Publishes research in basic sciences, molecular biology, clinical and experimental hypertension, cardiology, epidemiology, pediatric hypertension, endocrinology, neurophysiology, and nephrology.
academic.oup.com
November 17, 2025 at 12:45 PM
Reposted by Brandi M. Wynne, MS PhD FAHA
hswapnil.medsky.social
though i wonder if a large cohort study is the best way to demonstrate any effect

it's good to show overall importance - but many of these drugs are not predictable - like AIN these effects are somewhat idiosyncratic?

cc @aisha-shaikh.bsky.social @kdjhaveri.bsky.social for more thoughts
November 6, 2025 at 10:30 PM
Reposted by Brandi M. Wynne, MS PhD FAHA
hswapnil.medsky.social
large cohort study of
CDK 4/6
BRAF
EGFR
VEGF
and other cancer treatments

#OncoNephrology #NephSky #KidneyWk

jamanetwork.com/journals/jam... from Shuchi Anand et al from @stanfordmedicine.bsky.social
The subdistribution hazard ratios for progressive kidney dysfunction are shown for each drug group compared with their respective propensity score–matched cohort. The blue dots represent the hazard ratio and 95% CIs. Due to wide confidence intervals, MET inhibitors results reported in the text and not displayed here. MET inhibitors are included in overall treated group. Model is adjusted for hypertension, diabetes, ischemic heart disease, congestive heart failure, chronic obstructive pulmonary disease, cirrhosis, age, sex, race, body mass index, and eGFR before drug start. ALK indicates anaplastic lymphoma kinase; BRAF, B-Raf proto-oncogene, serine/threonine kinase; CDK4/6, cyclin dependent kinase 4 or 6; EGFR, endothelial growth factor receptor; ERBB2, human epidermal growth factor receptor 2; PARP, poly(adenosine diphosphate-ribose) polymerase; VEGFR, vascular endothelial growth factor receptor.
November 6, 2025 at 10:30 PM
Reposted by Brandi M. Wynne, MS PhD FAHA
amjhypertension.bsky.social
Cardiac Biomarkers in Pregnancies With and Without Hypertension

#EditorsChoice from September issue

🔗 academic.oup.com/ajh/article/... 🔓

#Hypertension #HDP #OpenAccess
Cardiac Biomarkers in Pregnancies With and Without Hypertension
AbstractBackground. Mechanisms of injury due to hypertension (HTN) in pregnancy remain poorly characterized. This study examined trends in markers of cardi
academic.oup.com
September 23, 2025 at 11:01 AM
Reposted by Brandi M. Wynne, MS PhD FAHA
amjhypertension.bsky.social
Comparative Outcomes of Adrenalectomy, Mineralocorticoid Receptor Antagonist, and Percutaneous Adrenal Ablation for Primary Aldosteronism: A Systematic Review and Network Meta-Analysis

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#Aldosteronism #Hypertension
Comparative Outcomes of Adrenalectomy, Mineralocorticoid Receptor Antagonist, and Percutaneous Adrenal Ablation for Primary Aldosteronism: A Systematic Review and Network Meta-Analysis
AbstractBACKGROUND. Percutaneous adrenal ablation (PAA) is an effective and safe therapy for treating patients with primary aldosteronism (PA). However, it
academic.oup.com
September 29, 2025 at 11:45 AM
Reposted by Brandi M. Wynne, MS PhD FAHA
amjhypertension.bsky.social
Strategies for Success: Million Hearts Hypertension Control Champions

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Strategies for Success: Million Hearts Hypertension Control Champions
AbstractBACKGROUND. Among the 119.9 million US adults with hypertension, an estimated 92.9 million have systolic blood pressure ≥ 130 mm Hg or diastolic bl
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October 1, 2025 at 1:09 AM
Reposted by Brandi M. Wynne, MS PhD FAHA
amjhypertension.bsky.social
Advances in Adrenal Ablation for Aldosteronism

Commentary academic.oup.com/ajh/article-...

Based on
academic.oup.com/ajh/article-...
and
academic.oup.com/ajh/article-...

#Aldosteronism #Hypertension
Recent Advances in Adrenal Ablation for Primary Aldosteronism
Primary aldosteronism (PA) is characterized by autonomous renin-independent aldosterone production from one or both adrenal glands which leads to inappropr
academic.oup.com
October 1, 2025 at 2:30 PM
Reposted by Brandi M. Wynne, MS PhD FAHA
amjhypertension.bsky.social
Home Blood Pressure Monitoring Among Adolescents and Young Adults, NHANES 2009–2014

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#Free #OpenAccess
Home Blood Pressure Monitoring Among Adolescents and Young Adults, NHANES 2009–2014
AbstractBACKGROUND. Among middle-aged and older adults, home blood pressure (BP) monitoring (HBPM) is a tool for both diagnosis and management of hypertens
academic.oup.com
October 24, 2025 at 11:15 AM
Reposted by Brandi M. Wynne, MS PhD FAHA
amjhypertension.bsky.social
Plasma Reactive Dicarbonyls Are Not Independently Associated With Arterial Stiffness: The Maastricht Study

🔗 academic.oup.com/ajh/article/... 🔓

#OpenAccess #Free
Plasma Reactive Dicarbonyls Are Not Independently Associated With Arterial Stiffness: The Maastricht Study
AbstractBACKGROUND. Arterial stiffness is a strong predictor of cardiovascular diseases and all-cause mortality. Increased concentrations of highly reactiv
academic.oup.com
October 21, 2025 at 12:45 PM
Reposted by Brandi M. Wynne, MS PhD FAHA
amjhypertension.bsky.social
Association of Anxiety with Discrepancies Between Unattended and Attended Office Blood Pressure Measurement

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Association of Anxiety with Discrepancies Between Unattended and Attended Office Blood Pressure Measurement
AbstractBACKGROUND. Precision of blood pressure (BP) measurements is crucial in hypertension care. Conventional office measurements (OBP) are susceptible t
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October 22, 2025 at 11:30 AM
Reposted by Brandi M. Wynne, MS PhD FAHA
amjhypertension.bsky.social
Plasmacytoid Dendritic Cell Content Is Associated With Plasma Aldosterone Concentration in Patients With Primary Aldosteronism

🔗 academic.oup.com/ajh/article/... 🔒

#Aldosteronism #Hypertension
Plasmacytoid Dendritic Cell Content Is Associated With Plasma Aldosterone Concentration in Patients With Primary Aldosteronism
AbstractBACKGROUND. Inflammation plays a pivotal role in blood pressure regulation. Current data reflect the important role of T cells in primary hypertens
academic.oup.com
September 30, 2025 at 11:45 AM
Reposted by Brandi M. Wynne, MS PhD FAHA
amjhypertension.bsky.social
Comparing Management strategies for Primary Aldosteronism: Is it 🍎 versus 🍊 ?

Commentary academic.oup.com/ajh/article-...

based on
academic.oup.com/ajh/article-...

#Hypertension #Aldosteronism
Optimal Treatment of Primary Aldosteronism: Can We Compare Apples to Oranges?
Primary aldosteronism (PA) is an endocrine disorder characterized by inappropriate and excessive aldosterone production.1 PA is a prevalent cause of elevat
academic.oup.com
October 2, 2025 at 10:15 AM
Reposted by Brandi M. Wynne, MS PhD FAHA
amjhypertension.bsky.social
Stenotic Lesions of the Intracranial Arteries in Relation to the Average Level and Variability of the Home Blood Pressure: A Cross-Sectional Study

🔗 academic.oup.com/ajh/article/... 🔓

#OpenAccess #Free
Stenotic Lesions of the Intracranial Arteries in Relation to the Average Level and Variability of the Home Blood Pressure: A Cross-Sectional Study
AbstractBACKGROUND. This study assessed the presence of intracranial arterial stenosis (ICAS) in relation to home systolic blood pressure (SBP) and its var
academic.oup.com
October 20, 2025 at 10:01 AM
Reposted by Brandi M. Wynne, MS PhD FAHA
amjhypertension.bsky.social
#ThrowbackThursday

Glomeruli and Blood Pressure: Less of One, More of the Other?

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from Brenner, Garcia and Anderson, 1988
Glomeruli and Blood Pressure: Less of One, More the Other?
Abstract. A primary role for the kidney in the initiation and maintenance of hypertension has long been recognized, but the pathogenetic interactions among
academic.oup.com
October 2, 2025 at 1:45 PM
Reposted by Brandi M. Wynne, MS PhD FAHA
amjhypertension.bsky.social
Commentary on 'Plasmacytoid Dendritic Cell Content Is Associated With Plasma Aldosterone Concentration in Patients With Primary Aldosteronism'

academic.oup.com/ajh/article-...

based on
academic.oup.com/ajh/article-...
Commentary on “Plasmacytoid Dendritic Cell Content Is Associated With Plasma Aldosterone Concentration in Patients With Primary Aldosteronism”
Primary aldosteronism (PA) is a leading cause of secondary hypertension, characterized by autonomous aldosterone excess, which drives sodium retention, vol
academic.oup.com
October 3, 2025 at 11:45 AM
Reposted by Brandi M. Wynne, MS PhD FAHA
amjhypertension.bsky.social
Blood Pressure Outcomes Following a Home Blood Pressure Monitoring Program in a Large Integrated US Health System

🔗 academic.oup.com/ajh/article/... 🔓

#EditorsChoice #Free
Blood Pressure Outcomes Following a Home Blood Pressure Monitoring Program in a Large Integrated US Health System
AbstractBackground. Home blood pressure telemonitoring (HBPT) can empower patients to participate in their healthcare and reduce office BP. Evidence that B
academic.oup.com
October 10, 2025 at 9:30 AM
Reposted by Brandi M. Wynne, MS PhD FAHA
amjhypertension.bsky.social
Adherence to Recommended Laboratory Testing for #Hypertension: Insights from a Nationwide Cohort

🔗 academic.oup.com/ajh/article/... 🔒
Adherence to Recommended Laboratory Testing for Hypertension: Insights from a Nationwide Cohort
AbstractBACKGROUND. Despite guideline recommendations, the prevalence of laboratory testing among patients newly diagnosed with hypertension (HTN) in the U
academic.oup.com
October 13, 2025 at 11:45 AM
Reposted by Brandi M. Wynne, MS PhD FAHA
amjhypertension.bsky.social
Association Between Estimated Daily Salt Intake from Spot Urine and Nocturnal Blood Pressure in Hypertensive Patients under Antihypertensive Treatment

🔗 academic.oup.com/ajh/article/... 🔒
Association Between Estimated Daily Salt Intake from Spot Urine and Nocturnal Blood Pressure in Hypertensive Patients under Antihypertensive Treatment
AbstrcatBackground. Excessive salt intake is a major contributor to hypertension and is associated with elevated nocturnal blood pressure (BP), particularl
academic.oup.com
October 14, 2025 at 2:15 PM
Reposted by Brandi M. Wynne, MS PhD FAHA
amjhypertension.bsky.social
The Association Between Diabetes and Hypertension Time Course, Their Cumulative CoExposure, and PostCoronary Artery Bypass Graft Outcomes

🔗 academic.oup.com/ajh/article/... 🔒
The Association Between Diabetes and Hypertension Time Course, Their Cumulative CoExposure, and PostCoronary Artery Bypass Graft Outcomes
AbstractBACKGROUND. The association between patient outcomes and cumulative effects of cardiovascular risk factors over time is recognized but poorly quant
academic.oup.com
October 15, 2025 at 1:31 PM
Reposted by Brandi M. Wynne, MS PhD FAHA
amjhypertension.bsky.social
Vascular Stiffness, Instead of Coronary Artery Calcification, Exhibits Significant Association With Hypertension Risk in General Population

🔗 academic.oup.com/ajh/article/... 🔒
The Association Between Diabetes and Hypertension Time Course, Their Cumulative CoExposure, and PostCoronary Artery Bypass Graft Outcomes
AbstractBACKGROUND. The association between patient outcomes and cumulative effects of cardiovascular risk factors over time is recognized but poorly quant
academic.oup.com
October 17, 2025 at 11:04 AM
Reposted by Brandi M. Wynne, MS PhD FAHA
amjhypertension.bsky.social
The endocannabinoid system as a target for thiazide diuretics?

academic.oup.com/ajh/advance-...

#WeekendReads from the #AdvanceArticles section
State of the Art Review: Thiazide Diuretics Exploit the Endocannabinoid System via NAPE-PLD
Abstract. The present State of the Art Review will take stock of targeting the endocannabinoid system (ECS) in the management of hypertension and vascular
academic.oup.com
October 12, 2025 at 9:30 AM
Reposted by Brandi M. Wynne, MS PhD FAHA
amjhypertension.bsky.social
Potential Therapeutic Drug Targets for Hypertension Identified Using Proteomics and Mendelian Randomization

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Potential Therapeutic Drug Targets for Hypertension Identified Using Proteomics and Mendelian Randomization
AbstractBACKGROUND. Hypertension (HT) is the most prevalent risk factor for cardiovascular disease (CVD) worldwide. Despite being a highly heritable trait,
academic.oup.com
October 7, 2025 at 11:45 AM
Reposted by Brandi M. Wynne, MS PhD FAHA
amjhypertension.bsky.social
#ThrowbackThursday

Two-Day ABPM-Derived Indices and Mortality in Hemodialysis Patients

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Two-Day ABPM-Derived Indices and Mortality in Hemodialysis Patients
AbstractBACKGROUND. Blood pressure (BP) and arterial stiffness are known cardiovascular risk factors in hemodialysis (HD) patients. This study examines the
academic.oup.com
October 9, 2025 at 8:30 AM
Reposted by Brandi M. Wynne, MS PhD FAHA
amjhypertension.bsky.social
#weekendReads from the #EditorsChoice

Does Reserpine deserve a Relook for Resistant Hypertension?

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#Free
Reserpine Substantially Lowers Blood Pressure in Patients With Refractory Hypertension: A Proof-of-Concept Study
AbstractBACKGROUND. Refractory hypertension (RfHTN), a phenotype of antihypertensive treatment failure, is defined as uncontrolled automated office blood p
academic.oup.com
October 5, 2025 at 3:02 PM