Antony W. Oliver (Tony)
@antonywoliver.bsky.social
News, views and opinions of Dr Antony W Oliver, Principal Research Fellow in the Genome Damage and Stability Centre, University of Sussex, UK @gdsc-sussex
Enjoying a little rest and recuperation in Rejkyavik, Iceland.
September 3, 2025 at 3:33 PM
Enjoying a little rest and recuperation in Rejkyavik, Iceland.
Reposted by Antony W. Oliver (Tony)
#New-Paper Rass laboratory reveal DNA2 to be a gatekeeper to homologous recombination at stalled DNA replication forks, rrequired to stave off cellular senescence. Their findings provide a molecular explanation for the association of DNA2 with primordial dwarfism and cancer.
doi.org/10.1038/s415...
doi.org/10.1038/s415...
DNA2 enables growth by restricting recombination-restarted replication - Nature
DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...
doi.org
September 3, 2025 at 3:13 PM
#New-Paper Rass laboratory reveal DNA2 to be a gatekeeper to homologous recombination at stalled DNA replication forks, rrequired to stave off cellular senescence. Their findings provide a molecular explanation for the association of DNA2 with primordial dwarfism and cancer.
doi.org/10.1038/s415...
doi.org/10.1038/s415...
... and this one too! Again, quite amazing microscopy. Major congrats to Maria + colleagues for getting this story online.
#NEW_PAPER
In this study, the Chan Lab uncover the molecular mechanisms by which human cells safeguard centromeric chromatin during mitosis, via tight dynamic control of the Bloom Syndrome complex (BTRR).
rdcu.be/eCGxF
In this study, the Chan Lab uncover the molecular mechanisms by which human cells safeguard centromeric chromatin during mitosis, via tight dynamic control of the Bloom Syndrome complex (BTRR).
rdcu.be/eCGxF
Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex
Nature Communications - Centromeres play an essential function in faithful chromosome segregation. Here, the authors demonstrate the mechanism by which human cells dynamically modulate the activity...
rdcu.be
August 30, 2025 at 11:28 AM
... and this one too! Again, quite amazing microscopy. Major congrats to Maria + colleagues for getting this story online.
A bit like buses...
Nice to see this work online - there is quite the amazing amount of data in this manuscript, all power to Rob Zach + colleagues!
Nice to see this work online - there is quite the amazing amount of data in this manuscript, all power to Rob Zach + colleagues!
#NEW_PAPER
The Hochegger laboratory + collaborators investigate the sensitivity of cancer cells to a highly selective inhibitor of human Greatwall kinase (GWL) + the BB5alpha-to-GWL expression ratio is a predictive biomarker for the cellular reponse to Greatwall-targeted therapeutics. rdcu.be/eC4Hf
The Hochegger laboratory + collaborators investigate the sensitivity of cancer cells to a highly selective inhibitor of human Greatwall kinase (GWL) + the BB5alpha-to-GWL expression ratio is a predictive biomarker for the cellular reponse to Greatwall-targeted therapeutics. rdcu.be/eC4Hf
The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells
Nature Communications - The authors develop and characterise a selective Greatwall inhibitor, C-604, and show that its cytotoxicity stems from PP2A-B55α hyperactivation. They identify...
rdcu.be
August 30, 2025 at 11:26 AM
A bit like buses...
Nice to see this work online - there is quite the amazing amount of data in this manuscript, all power to Rob Zach + colleagues!
Nice to see this work online - there is quite the amazing amount of data in this manuscript, all power to Rob Zach + colleagues!
Reposted by Antony W. Oliver (Tony)
Many congratulations to Dr. Will Foster on succesfully defending his PhD thesis on Greatwall Kinase (GWL); co-supervissed by Tony Oliver and Helfrid Hochegger.
February 28, 2025 at 5:34 PM
Many congratulations to Dr. Will Foster on succesfully defending his PhD thesis on Greatwall Kinase (GWL); co-supervissed by Tony Oliver and Helfrid Hochegger.
Well, I’ve joined BlueSky… (at long last) and look forward to posting some stuff on here soonest. Meanwhile @gdsc-sussex.bsky.social have also made the transition!
December 6, 2024 at 7:38 PM
Well, I’ve joined BlueSky… (at long last) and look forward to posting some stuff on here soonest. Meanwhile @gdsc-sussex.bsky.social have also made the transition!