Antonios Pantazis lab
@antoniospantazis.bsky.social
Assoc. prof. in #ionchannel physiology & #channelopathy at Linköping University. Ever excited about the proteins that control excitability.
https://liu.se/en/research/palace
https://liu.se/en/research/palace
Pinned
A rich conformational palette underlies human CaV2.1-channel availability
Nature Communications - CaV2.1 channels are critical for neuronal communication. Here, authors showed they undergo electrically-evoked molecular movements which (1) eventually trigger...
rdcu.be
Out now at Nat Comm: "A rich conformational palette 🎨 underlies human CaV2.1-channel availability"
1. VSD-I activation triggers transmitter release
2. VSD-I conversion causes VDI & contributes to plasticity
3. CaV2.1 channels have several conformations at Vrest
#neuroskyence #CACNA1A
rdcu.be/ei0Tm
1. VSD-I activation triggers transmitter release
2. VSD-I conversion causes VDI & contributes to plasticity
3. CaV2.1 channels have several conformations at Vrest
#neuroskyence #CACNA1A
rdcu.be/ei0Tm
"Hearts and Minds" achievement unlocked! Our lab is now receiving simultaneous funding by the Swedish Heart-Lung Foundation ❤️ and the Swedish Brain Foundation 🧠!
(been waiting all year to be able to say this)
(been waiting all year to be able to say this)
November 10, 2025 at 2:53 PM
"Hearts and Minds" achievement unlocked! Our lab is now receiving simultaneous funding by the Swedish Heart-Lung Foundation ❤️ and the Swedish Brain Foundation 🧠!
(been waiting all year to be able to say this)
(been waiting all year to be able to say this)
Reposted by Antonios Pantazis lab
2nd #WSCC26 will take place in Grindelwald (Switzerland) 🚠 from 4th to 6th of February, 2026.
🌍 Join @lampertlab.bsky.social , @antoniospantazis.bsky.social, @khannalabuf.bsky.social, and others.
💡 Submit abstracts by the 26th of September, 2025:
lnkd.in/eDhPUVKd
💻 More info:
lnkd.in/eJw9pfMz
🌍 Join @lampertlab.bsky.social , @antoniospantazis.bsky.social, @khannalabuf.bsky.social, and others.
💡 Submit abstracts by the 26th of September, 2025:
lnkd.in/eDhPUVKd
💻 More info:
lnkd.in/eJw9pfMz
September 1, 2025 at 11:14 AM
2nd #WSCC26 will take place in Grindelwald (Switzerland) 🚠 from 4th to 6th of February, 2026.
🌍 Join @lampertlab.bsky.social , @antoniospantazis.bsky.social, @khannalabuf.bsky.social, and others.
💡 Submit abstracts by the 26th of September, 2025:
lnkd.in/eDhPUVKd
💻 More info:
lnkd.in/eJw9pfMz
🌍 Join @lampertlab.bsky.social , @antoniospantazis.bsky.social, @khannalabuf.bsky.social, and others.
💡 Submit abstracts by the 26th of September, 2025:
lnkd.in/eDhPUVKd
💻 More info:
lnkd.in/eJw9pfMz
Reposted by Antonios Pantazis lab
Very excited to share our most recent work on using de novo design to custom engineer a small peptide that can restore proper sodium channel function in disease … to be able to “write” proteins to do whatever we want them to do, is just remarkable …
Now online! De novo design of a peptide modulator to reverse sodium channel dysfunction linked to cardiac arrhythmias and epilepsy
De novo design of a peptide modulator to reverse sodium channel dysfunction linked to cardiac arrhythmias and epilepsy
De novo protein design was used to engineer a peptide that reverses gain-of-function deficits in voltage-gated sodium channels linked to cardiac arrhythmia and epilepsy.
dlvr.it
August 20, 2025 at 3:09 PM
Very excited to share our most recent work on using de novo design to custom engineer a small peptide that can restore proper sodium channel function in disease … to be able to “write” proteins to do whatever we want them to do, is just remarkable …
Reposted by Antonios Pantazis lab
SOX2 and NR2F1 cooperate
to make #neurons in the #Thalamus
for visual input from the #retina
#DevBio
journals.biologists.com/bio/article/...
@biologyopen.bsky.social
In collab w Sara Mercurio and Silvia Nicolis @btbsunimib.bsky.social
Driven by Linda Serra and @annanordin.bsky.social
to make #neurons in the #Thalamus
for visual input from the #retina
#DevBio
journals.biologists.com/bio/article/...
@biologyopen.bsky.social
In collab w Sara Mercurio and Silvia Nicolis @btbsunimib.bsky.social
Driven by Linda Serra and @annanordin.bsky.social
SOX2 and NR2F1 coordinate the gene expression program of the early postnatal visual thalamus
Summary: The transcriptional regulators SOX2 and NR2F1 drive the development of the visual thalamus. Mutations in these genes cause visual impairment in humans.
journals.biologists.com
August 11, 2025 at 12:55 PM
SOX2 and NR2F1 cooperate
to make #neurons in the #Thalamus
for visual input from the #retina
#DevBio
journals.biologists.com/bio/article/...
@biologyopen.bsky.social
In collab w Sara Mercurio and Silvia Nicolis @btbsunimib.bsky.social
Driven by Linda Serra and @annanordin.bsky.social
to make #neurons in the #Thalamus
for visual input from the #retina
#DevBio
journals.biologists.com/bio/article/...
@biologyopen.bsky.social
In collab w Sara Mercurio and Silvia Nicolis @btbsunimib.bsky.social
Driven by Linda Serra and @annanordin.bsky.social
Glass of tequila and a play through of Pet Sounds. RIP Brian Wilson, on a very Californian evening in southern Sweden.
June 12, 2025 at 6:01 PM
Glass of tequila and a play through of Pet Sounds. RIP Brian Wilson, on a very Californian evening in southern Sweden.
Out now at Nat Comm: "A rich conformational palette 🎨 underlies human CaV2.1-channel availability"
1. VSD-I activation triggers transmitter release
2. VSD-I conversion causes VDI & contributes to plasticity
3. CaV2.1 channels have several conformations at Vrest
#neuroskyence #CACNA1A
rdcu.be/ei0Tm
1. VSD-I activation triggers transmitter release
2. VSD-I conversion causes VDI & contributes to plasticity
3. CaV2.1 channels have several conformations at Vrest
#neuroskyence #CACNA1A
rdcu.be/ei0Tm
A rich conformational palette underlies human CaV2.1-channel availability
Nature Communications - CaV2.1 channels are critical for neuronal communication. Here, authors showed they undergo electrically-evoked molecular movements which (1) eventually trigger...
rdcu.be
May 2, 2025 at 10:46 AM
Out now at Nat Comm: "A rich conformational palette 🎨 underlies human CaV2.1-channel availability"
1. VSD-I activation triggers transmitter release
2. VSD-I conversion causes VDI & contributes to plasticity
3. CaV2.1 channels have several conformations at Vrest
#neuroskyence #CACNA1A
rdcu.be/ei0Tm
1. VSD-I activation triggers transmitter release
2. VSD-I conversion causes VDI & contributes to plasticity
3. CaV2.1 channels have several conformations at Vrest
#neuroskyence #CACNA1A
rdcu.be/ei0Tm
Reposted by Antonios Pantazis lab
An immensely interesting seminar with plot twists is going to take place next Tuesday! 🕵
⚡ Join the exciting talk of @antoniospantazis.bsky.social titled "Even a single carbon atom matters: deadly and unexpected consequences of a Nav1.5 variant". 🫀
to connect: lnkd.in/evCC__x7
⚡ Join the exciting talk of @antoniospantazis.bsky.social titled "Even a single carbon atom matters: deadly and unexpected consequences of a Nav1.5 variant". 🫀
to connect: lnkd.in/evCC__x7
April 23, 2025 at 9:13 AM
An immensely interesting seminar with plot twists is going to take place next Tuesday! 🕵
⚡ Join the exciting talk of @antoniospantazis.bsky.social titled "Even a single carbon atom matters: deadly and unexpected consequences of a Nav1.5 variant". 🫀
to connect: lnkd.in/evCC__x7
⚡ Join the exciting talk of @antoniospantazis.bsky.social titled "Even a single carbon atom matters: deadly and unexpected consequences of a Nav1.5 variant". 🫀
to connect: lnkd.in/evCC__x7
Reposted by Antonios Pantazis lab
It will be turbulent in the next worldwide sodium channel seminar: @antoniospantazis.bsky.social will explain why "Even a single carbon atom matters: deadly and unexpected consequences of a Nav1.5 variant" Tuesday April 29th. Visit www.sodiumchannelseminars.org for link and infos. #sodiumchannel
April 16, 2025 at 4:17 PM
It will be turbulent in the next worldwide sodium channel seminar: @antoniospantazis.bsky.social will explain why "Even a single carbon atom matters: deadly and unexpected consequences of a Nav1.5 variant" Tuesday April 29th. Visit www.sodiumchannelseminars.org for link and infos. #sodiumchannel
New paper blue-torial! On the surface, it's a new ⚡Nav1.5 #channelopathy causing 🫀 familial cardiac #arrhythmia. But our story has enough plot twists to rival MK Shyamalan!
www.jmcc-online.com/article/S002...
🧵 1/11
www.jmcc-online.com/article/S002...
🧵 1/11
Clinical and electrophysiological characterization of a SCN5A gain-of-function mutation associated with CPVT-like arrhythmia
The present study aimed to characterize the SCN5A variant I1333V, found in five families
with a history of suspected catecholaminergic polymorphic ventricular tachycardia
(CPVT). SCN5A encodes the por...
www.jmcc-online.com
April 13, 2025 at 10:59 AM
New paper blue-torial! On the surface, it's a new ⚡Nav1.5 #channelopathy causing 🫀 familial cardiac #arrhythmia. But our story has enough plot twists to rival MK Shyamalan!
www.jmcc-online.com/article/S002...
🧵 1/11
www.jmcc-online.com/article/S002...
🧵 1/11
Reposted by Antonios Pantazis lab
Spread the news! Grants available to recruit scientists from outside of Europe to Sweden 🇸🇪 🧠
Please re-post.
Please re-post.
New grant for recruiting researchers active outside Europe
In mid-April, the Swedish Research Council will issue a call for grants of 2 million SEK to enable Swedish higher education institutions and other research organisations to recruit prominent researche...
www.vr.se
April 3, 2025 at 6:00 PM
Spread the news! Grants available to recruit scientists from outside of Europe to Sweden 🇸🇪 🧠
Please re-post.
Please re-post.