#FluorescenceFriday & Erythroblast

Erythroblast stimulated with CXCL12, stained for CXCR4 (green) and nuclei (blue).

Captured via Correlative Light & Electron Microscopy by
@jemimaburden.bsky.social

Learn more: scim.ag/4kTxFZz
@antalpedro.bsky.social
@jffoley.bsky.social
@science.org

Enjoyed a fantastic WHRI Review Day yesterday and the Dufton Group came away with not one, but two, Poster Prizes! Congrats to Dr Josh Dignam and Ms Christina Gkantsinikoudi 🏆 @qmulwhri.bsky.social

Fantastic to see a paper I played a small part of get highlighted on the Science website. Congrats to the amazing Dr Julia Gutjarh and the whole of Prof Antal Rot’s team at @qmulwhri.bsky.social @science.org

In our science.org/doi/10.1126/... we describe the hitherto overlooked erythroblast expression of CXCR4, which do not migrate in response to CXCR4 ligation by CXCL12. Instead, in these cells CXCR4 localises to the nucleus and mediates alternative cell responses in maturation and triggers enucleation

CXCL12-stimulated intracellular and nuclear CXCR4 signaling mediates erythroblast enucleation to generate red blood cells
www.science.org/doi/10.1126/...

Yesterday.. our #CLEM with Julia Gutjahr and Antal Rot was featured in the main Science webpage....☺️ Nice to see #correlativemicroscopy and #volumeEM up front and centre.

www.science.org/doi/10.1126/...

With the right link:
www.science.org/doi/10.1126/...