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ansarilab.bsky.social
@ansarilab.bsky.social
43 followers 110 following 7 posts
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ansarilab.bsky.social
Another new paper alert fro CBT! Andrew Huber in the Chen Lab published work on degradation of nuclear receptors.
nature.com/articles/s41...
@StJudeResearch
#DrugDiscovery
PROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors - Nature Communications
Chemically induced protein degradation is a powerful alternative to classical inhibition, but some proteins have deeply masked binding pockets that make the development of degrader molecules difficult...
nature.com
November 11, 2025 at 4:29 PM
ansarilab.bsky.social
Excellent research out of the Lee Lab by
@stjudegraduate
student Hannah Snoke!
bit.ly/SnokeACSID25
@stjuderesearch.bsky.social
#infectiousdiseases #DrugDiscovery
Development of Pyrimido Pyridazine Analogs through Increased Whole Cell Target Engagement of the Dihydropteroate Synthase Pterin Binding Site in Gram-Negative Bacteria
Dihydropteroate synthase (DHPS) is a critical enzyme in the folate biosynthetic pathway of bacteria, fungi, and protozoans. Sulfonamides successfully target the p-aminobenzoic acid (pABA) binding site...
bit.ly
November 10, 2025 at 6:43 PM
ansarilab.bsky.social
New findings on kinase phosphorylation of RNA polymerase II from the Ansari Lab!
bit.ly/Dabas_Pol2
Kinase atlas uncovers hidden layers of cell signaling regulation
See how St. Jude scientists linked 117 kinases including EGFR tyrosine kinase to RNA polymerase II phosphorylation, revealing new targets for cancer therapy.
bit.ly
November 7, 2025 at 3:45 PM
Reposted
stjuderesearch.bsky.social
Attend the 2025 Bringing Chemistry to Medicine Symposium to learn from leading experts in transcription, chromatin regulation, computational biology and chemical biology. Registration is free and available both in-person and virtually.
July 14, 2025 at 4:00 PM
Reposted
stjuderesearch.bsky.social
St. Jude is hosting its annual Bringing Chemistry to Medicine Symposium October 2-3, 2025, in Memphis, TN. In collaboration with @cellpress.bsky.social, the event features global experts sharing cutting-edge advancements at the intersection of chemical and biomedical sciences.
June 17, 2025 at 6:00 PM
Reposted
ansarilab.bsky.social
Are you a #drughunter looking to have a direct impact on patients? The Department of Chemical Biology and Therapeutics is seeking a Principal Scientist in Chemical Induced Proximity to lead a new group.
talent.stjude.org/careers/jobs...
Principal Scientist in Chemical Induced Proximity in Memphis, Tennessee | St. Jude Careers
St. Jude Careers is hiring a Principal Scientist in Chemical Induced Proximity in Memphis, Tennessee. Review all of the job details and apply today!
talent.stjude.org
May 23, 2025 at 8:44 PM
ansarilab.bsky.social
Are you a #drughunter looking to have a direct impact on patients? The Department of Chemical Biology and Therapeutics is seeking a Principal Scientist in Chemical Induced Proximity to lead a new group.
talent.stjude.org/careers/jobs...
Principal Scientist in Chemical Induced Proximity in Memphis, Tennessee | St. Jude Careers
St. Jude Careers is hiring a Principal Scientist in Chemical Induced Proximity in Memphis, Tennessee. Review all of the job details and apply today!
talent.stjude.org
May 23, 2025 at 8:44 PM
ansarilab.bsky.social
We're hiring! CBT is seeking a principal scientist to led efforts in induced proximity strategies for drug discovery. Join our highly collaborative team!
talent.stjude.org/careers/jobs...
Principal Scientist in Chemical Induced Proximity in Memphis, Tennessee | St. Jude Careers
St. Jude Careers is hiring a Principal Scientist in Chemical Induced Proximity in Memphis, Tennessee. Review all of the job details and apply today!
talent.stjude.org
May 6, 2025 at 4:33 PM
ansarilab.bsky.social
Cool stuff happening in the Chen Lab!
www.stjude.org/media-resour...
Study provides scaffold to selectively target drug breakdown process
See how a panel of CYP3A4 inhibitors lay groundwork for selective cytochrome P450 inhibition by avoiding CYP3A5.
www.stjude.org
May 1, 2025 at 4:56 PM
Reposted
rhodamine110.bsky.social
Had a blast writing this piece celebrating the latest paper in @pubs.acs.org from @ellensletten.bsky.social and Ellen’s general awesomeness. My 11-year old daughter was my coauthor! (try to find all the Easter Eggs) pubs.acs.org/doi/10.1021/...
Stars by the Pocketful
SWIR dyes─The Eras Tour. This love story between chemistry and biology shines.
pubs.acs.org
February 13, 2025 at 10:48 PM