Amirhossein Nayeri Rad
@amirhosseinnr.bsky.social
PharmD | Interested in therapeutic developmemt targeting senescence in diseases
Reposted by Amirhossein Nayeri Rad
Reposted by Amirhossein Nayeri Rad
KRAS Inhibition Reverses Chemotherapy Resistance Promoted by Therapy-Induced Senescence-like in Pancreatic Ductal Adenocarcinoma 🧪 www.biorxiv.org/content/10.1...
KRAS Inhibition Reverses Chemotherapy Resistance Promoted by Therapy-Induced Senescence-like in Pancreatic Ductal Adenocarcinoma
Background: Emerging evidence suggests that chemotherapy can accumulate senescent-like cells within tumor tissues, a phenomenon linked to therapy resistance. The aim of this study is to analyze the se...
www.biorxiv.org
April 19, 2025 at 7:46 AM
KRAS Inhibition Reverses Chemotherapy Resistance Promoted by Therapy-Induced Senescence-like in Pancreatic Ductal Adenocarcinoma 🧪 www.biorxiv.org/content/10.1...
Reposted by Amirhossein Nayeri Rad
My latest post is now out.
I show how Trump's attacks on science and universities are neither random nor new - they fit very precisely into the authoritarian playbook.
This means we can guess what might come next and prepare - and we must!
christinapagel.substack.com/p/censor-pur...
I show how Trump's attacks on science and universities are neither random nor new - they fit very precisely into the authoritarian playbook.
This means we can guess what might come next and prepare - and we must!
christinapagel.substack.com/p/censor-pur...
Censor, purge, defund: how Trump following the authoritarian playbook on science and universities
I have mapped 35 of the Trump administration's attacks on science and universities to the authoritarian playbook - and consider what it means for attacks still to come
christinapagel.substack.com
March 10, 2025 at 2:58 PM
My latest post is now out.
I show how Trump's attacks on science and universities are neither random nor new - they fit very precisely into the authoritarian playbook.
This means we can guess what might come next and prepare - and we must!
christinapagel.substack.com/p/censor-pur...
I show how Trump's attacks on science and universities are neither random nor new - they fit very precisely into the authoritarian playbook.
This means we can guess what might come next and prepare - and we must!
christinapagel.substack.com/p/censor-pur...
Reposted by Amirhossein Nayeri Rad
Disturbed proteostasis is the key event that triggers cellular senescence through the regulation of chromatin organization and genome stability https://www.biorxiv.org/content/10.1101/2025.03.03.641349v1
March 4, 2025 at 12:30 PM
Disturbed proteostasis is the key event that triggers cellular senescence through the regulation of chromatin organization and genome stability https://www.biorxiv.org/content/10.1101/2025.03.03.641349v1
Reposted by Amirhossein Nayeri Rad
A team of @mskcancercenter.bsky.social researchers led a study in mice evaluating KMT2C/D–KDM6A gene loss in #urothelialcarcinoma. While the loss of these genes promotes cancer, they may also make cells more sensitive to certain drugs. #blcsm @naturegenet.bsky.social www.nature.com/articles/s41...
Loss of Kmt2c or Kmt2d primes urothelium for tumorigenesis and redistributes KMT2A–menin to bivalent promoters - Nature Genetics
Loss of Kmt2c or Kmt2d in mice drives the redeployment of KMT2A–menin to bivalent promoters, leading to changes in gene expression. This primes cells for transformation and elicits sensitivity to EGFR...
www.nature.com
March 3, 2025 at 5:58 PM
A team of @mskcancercenter.bsky.social researchers led a study in mice evaluating KMT2C/D–KDM6A gene loss in #urothelialcarcinoma. While the loss of these genes promotes cancer, they may also make cells more sensitive to certain drugs. #blcsm @naturegenet.bsky.social www.nature.com/articles/s41...
Reposted by Amirhossein Nayeri Rad
🚨 Big news! 🚨 Our lab's latest paper by Jamil Nehme (@jamilnehme.bsky.social) is out now:
Pharmacological CDK4/6 inhibition promotes vulnerability to lysosomotropic agents in breast cancer.
Check it out! (doi.org/10.1038/s443...) Congrats, Jamil! #CancerResearch #CDK46 #BreastCancer
Pharmacological CDK4/6 inhibition promotes vulnerability to lysosomotropic agents in breast cancer.
Check it out! (doi.org/10.1038/s443...) Congrats, Jamil! #CancerResearch #CDK46 #BreastCancer
February 10, 2025 at 4:12 PM
🚨 Big news! 🚨 Our lab's latest paper by Jamil Nehme (@jamilnehme.bsky.social) is out now:
Pharmacological CDK4/6 inhibition promotes vulnerability to lysosomotropic agents in breast cancer.
Check it out! (doi.org/10.1038/s443...) Congrats, Jamil! #CancerResearch #CDK46 #BreastCancer
Pharmacological CDK4/6 inhibition promotes vulnerability to lysosomotropic agents in breast cancer.
Check it out! (doi.org/10.1038/s443...) Congrats, Jamil! #CancerResearch #CDK46 #BreastCancer
Reposted by Amirhossein Nayeri Rad
The shortest telomere in telomerase-negative cells triggers replicative senescence at a critical threshold length and also fuels genomic instability https://www.biorxiv.org/content/10.1101/2025.01.27.635053v1
January 29, 2025 at 9:19 PM
The shortest telomere in telomerase-negative cells triggers replicative senescence at a critical threshold length and also fuels genomic instability https://www.biorxiv.org/content/10.1101/2025.01.27.635053v1