Alicia Madgwick
aliciamadgwick.bsky.social
Alicia Madgwick
@aliciamadgwick.bsky.social
DevBiologist ❤️ gene regulation. Postdoc on mouse limbs in Mundlos Lab MPI for Molecular Genetics. Previously PhD on ascidian enhancer-evo in Lemaire Lab CNRS-CRBM | she/her
Reposted by Alicia Madgwick
Reposted by Alicia Madgwick
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics
Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...
www.nature.com
July 9, 2025 at 10:05 AM