Alfred Fischer
@alfredodistefano.bsky.social
I love science, studied biology and am working with cancer drugs.
Twitter in German: https://x.com/alfredfischer17?s=21
Twitter in German: https://x.com/alfredfischer17?s=21
In this cohort study, air pollution exposure was consistently associated with increased risk of early-onset breast cancer.
#breastcancer #oncology #airquality #epidemiology
breast-cancer-research.biomedcentral.com/articles/10....
#breastcancer #oncology #airquality #epidemiology
breast-cancer-research.biomedcentral.com/articles/10....
Exposure to ambient air pollution during pregnancy and risk of early-onset breast cancer - Breast Cancer Research
Background Air pollution has been linked to breast cancer risk, but previous studies have seldom considered specific exposure windows, like pregnancy. During pregnancy the breast undergoes substantial...
breast-cancer-research.biomedcentral.com
November 17, 2025 at 11:32 AM
In this cohort study, air pollution exposure was consistently associated with increased risk of early-onset breast cancer.
#breastcancer #oncology #airquality #epidemiology
breast-cancer-research.biomedcentral.com/articles/10....
#breastcancer #oncology #airquality #epidemiology
breast-cancer-research.biomedcentral.com/articles/10....
November 16, 2025 at 10:34 AM
Desogestrel (a contraceptive) in particular is associated with a higher risk of breast cancer.
#oncology #medicine #breastcancer #contraceptives
t.co/mINJ1Qu6tP
#oncology #medicine #breastcancer #contraceptives
t.co/mINJ1Qu6tP
https://doi.org/10.1001/jamaoncol.2025.4480
t.co
November 15, 2025 at 6:41 PM
Desogestrel (a contraceptive) in particular is associated with a higher risk of breast cancer.
#oncology #medicine #breastcancer #contraceptives
t.co/mINJ1Qu6tP
#oncology #medicine #breastcancer #contraceptives
t.co/mINJ1Qu6tP
More and more “generics”, meaning biosimilars of antibody therapies are coming up.
www.medscape.com/viewarticle/...
www.medscape.com/viewarticle/...
First Pertuzumab Biosimilar Earns FDA Nod for Breast Cancer
Pertuzumab-dpzb is now considered an interchangeable biosimilar to pertuzumab as part of treatment combinations in multiple HER2-positive breast cancer indications.
www.medscape.com
November 15, 2025 at 6:40 PM
More and more “generics”, meaning biosimilars of antibody therapies are coming up.
www.medscape.com/viewarticle/...
www.medscape.com/viewarticle/...
This study suggests a mechanism that appears to reduce the risk of cancer from around age 85.
t.co/GtKiSIapoo
t.co/GtKiSIapoo
https://www.aging-us.com/article/103503/text
t.co
November 15, 2025 at 6:39 PM
This study suggests a mechanism that appears to reduce the risk of cancer from around age 85.
t.co/GtKiSIapoo
t.co/GtKiSIapoo
This meta-analysis found that trastuzumab emtansine was associated with the lowest incidence of LVEF decrease.
#breastcancer #her2 #oncology
jamanetwork.com/journals/jam...
#breastcancer #her2 #oncology
jamanetwork.com/journals/jam...
Antibody Drug Conjugates vs Standard Chemotherapy in ERBB2-Positive Advanced BC
This systematic review and meta-analysis compares the incidence of cardiotoxic effects of antibody-drug conjugates vs standard chemotherapy regimens for erb-b2 receptor tyrosine kinase 2 (ERBB2)–posit...
jamanetwork.com
November 12, 2025 at 11:46 AM
This meta-analysis found that trastuzumab emtansine was associated with the lowest incidence of LVEF decrease.
#breastcancer #her2 #oncology
jamanetwork.com/journals/jam...
#breastcancer #her2 #oncology
jamanetwork.com/journals/jam...
#Onthisday in 1966 Buzz Aldrin takes the first "space selfie," a photo of himself performing extravehicular activity in space during the Gemini 12 mission
November 12, 2025 at 11:30 AM
#Onthisday in 1966 Buzz Aldrin takes the first "space selfie," a photo of himself performing extravehicular activity in space during the Gemini 12 mission
Artificial intelligence (AI) can be used to identify women who have a particularly high risk of developing interval cancer between two screening mammograms.
doi.org/10.1148/radi...
doi.org/10.1148/radi...
Evaluation of a Mammography-based Deep Learning Model for Breast Cancer Risk Prediction in a Triennial Screening Program | Radiology
The results of this study support the use of generalized risk scores from mammography-based deep learning models to identify women who may benefit from supplemental imaging or shorter screening int...
doi.org
November 12, 2025 at 11:23 AM
Artificial intelligence (AI) can be used to identify women who have a particularly high risk of developing interval cancer between two screening mammograms.
doi.org/10.1148/radi...
doi.org/10.1148/radi...
In this trial, chest-wall irradiation did not result in higher overall survival than no chest-wall irradiation among patients with intermediate-risk, early breast cancer
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Ten-Year Survival after Postmastectomy Chest-Wall Irradiation in Breast Cancer | NEJM
The role of postmastectomy chest-wall irradiation in patients with breast cancer classified
as pN1 (with involvement of one to three axillary nodes) or pN0 (pathologically node
negative) with addit...
www.nejm.org
November 10, 2025 at 12:22 PM
In this trial, chest-wall irradiation did not result in higher overall survival than no chest-wall irradiation among patients with intermediate-risk, early breast cancer
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Breast cancer survivors did not exhibit a significantly increased risk of PD overall. However, younger survivors showed a possible age-related elevation in risk over time.
pubmed.ncbi.nlm.nih.gov/40905824/
pubmed.ncbi.nlm.nih.gov/40905824/
Risk of Parkinson's Disease among Breast Cancer Survivors: A Nationwide Cohort Study in South Korea - PubMed
This is the first nationwide study to evaluate PD risk among breast cancer survivors. Findings suggest the need for further investigation into age-specific neurodegenerative risks in breast cancer survivorship.
pubmed.ncbi.nlm.nih.gov
November 10, 2025 at 12:08 PM
Breast cancer survivors did not exhibit a significantly increased risk of PD overall. However, younger survivors showed a possible age-related elevation in risk over time.
pubmed.ncbi.nlm.nih.gov/40905824/
pubmed.ncbi.nlm.nih.gov/40905824/
On multivariate analysis, an anxiety diagnosis was associated with improved overall survival compared to no anxiety diagnosis.
#oncology #psychology
www.cancertherapyadvisor.com/news/anxiety...
#oncology #psychology
www.cancertherapyadvisor.com/news/anxiety...
Anxiety Increases irAEs but Boosts OS in Cancer Patients Receiving Immunotherapy
Study researchers noted that the findings suggest the association between anxiety and improved OS was at least partly related to the higher incidence of irAEs, which implies that, in people with an an...
www.cancertherapyadvisor.com
November 10, 2025 at 10:41 AM
On multivariate analysis, an anxiety diagnosis was associated with improved overall survival compared to no anxiety diagnosis.
#oncology #psychology
www.cancertherapyadvisor.com/news/anxiety...
#oncology #psychology
www.cancertherapyadvisor.com/news/anxiety...
The 10-year risk of breast cancer mortality was 11.8% for women in the statin group and 13.5% for women who did not receive statin therapy.
t.co/6ausFYEZVe
t.co/6ausFYEZVe
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2840709#xd_co_f=ZjU5ZmE0NGItY2M5MS00YmUyLWJmMDctOWY0NGY0N2ViZDRm
t.co
November 10, 2025 at 10:40 AM
The 10-year risk of breast cancer mortality was 11.8% for women in the statin group and 13.5% for women who did not receive statin therapy.
t.co/6ausFYEZVe
t.co/6ausFYEZVe
New data further illustrate how much many viral infections increase the risk of serious cardiovascular diseases such as heart attack and stroke – especially influenza and coronaviruses.
doi.org/10.1161/JAHA...
doi.org/10.1161/JAHA...
Viral Infections and Risk of Cardiovascular Disease: Systematic Review and Meta‐Analysis | Journal of the American Heart Association
doi.org
November 3, 2025 at 9:28 PM
New data further illustrate how much many viral infections increase the risk of serious cardiovascular diseases such as heart attack and stroke – especially influenza and coronaviruses.
doi.org/10.1161/JAHA...
doi.org/10.1161/JAHA...
Another study against sentinel lymph node biopsy.
Forgoing SLNB AND radiation therapy in older women (average age here: 76 years) with early-stage HR+, HER2- breast tumors yields almost identical results.
link.springer.com/article/10.1...
Forgoing SLNB AND radiation therapy in older women (average age here: 76 years) with early-stage HR+, HER2- breast tumors yields almost identical results.
link.springer.com/article/10.1...
Simultaneous Omission of Sentinel Lymph Node Biopsy and Radiation in Older Women with Early ER+ Breast Cancer - Annals of Surgical Oncology
Introduction Oncologic outcome data on women with neither SLNB nor radiation are limited. We evaluated recurrence and survival in older women with early stage, ER+/HER2 negative breast cancer who unde...
link.springer.com
November 3, 2025 at 11:58 AM
Another study against sentinel lymph node biopsy.
Forgoing SLNB AND radiation therapy in older women (average age here: 76 years) with early-stage HR+, HER2- breast tumors yields almost identical results.
link.springer.com/article/10.1...
Forgoing SLNB AND radiation therapy in older women (average age here: 76 years) with early-stage HR+, HER2- breast tumors yields almost identical results.
link.springer.com/article/10.1...
Despite the reduction in surgical interventions for older patients with early-stage breast cancer, sentinel lymph node biopsy (SLNB) is still performed on most patients.
#oncology #surgery
pubmed.ncbi.nlm.nih.gov/41165904/
#oncology #surgery
pubmed.ncbi.nlm.nih.gov/41165904/
Sentinel Lymph Node Biopsy in Low-Risk Breast Cancer in Patients ≥ 70 Years: How Wisely are We Choosing? - PubMed
Though there has been significant progress made in de-escalating surgical management of early-stage breast cancer in older patients, most patients are still undergoing SLNB. Moreover, patients in whom SLNB is being omitted appear more likely than before to receive adjuvant radiation. More work is ne …
pubmed.ncbi.nlm.nih.gov
November 3, 2025 at 11:51 AM
Despite the reduction in surgical interventions for older patients with early-stage breast cancer, sentinel lymph node biopsy (SLNB) is still performed on most patients.
#oncology #surgery
pubmed.ncbi.nlm.nih.gov/41165904/
#oncology #surgery
pubmed.ncbi.nlm.nih.gov/41165904/
Reposted by Alfred Fischer
⚠️ #BreastCancer doesn’t always come with warning signs.
This means awareness & early diagnosis are critical for everyone, regardless of lifestyle!
Know the signs (lump, skin changes, nipple discharge) & get screened.
This means awareness & early diagnosis are critical for everyone, regardless of lifestyle!
Know the signs (lump, skin changes, nipple discharge) & get screened.
October 31, 2025 at 3:47 PM
⚠️ #BreastCancer doesn’t always come with warning signs.
This means awareness & early diagnosis are critical for everyone, regardless of lifestyle!
Know the signs (lump, skin changes, nipple discharge) & get screened.
This means awareness & early diagnosis are critical for everyone, regardless of lifestyle!
Know the signs (lump, skin changes, nipple discharge) & get screened.
23 years of data confirm the usefulness of PSA screening.
#cancer #prostate #oncology
t.co/TvYDXQB1da
#cancer #prostate #oncology
t.co/TvYDXQB1da
https://www.aerzteblatt.de/news/psa-screening-langzeitdaten-bestatigen-senkung-der-prostatakarzinomspezifischen-mortalitat-ebaa2152-4a18-48da-9dde-4c0b8ca0f18e
t.co
October 31, 2025 at 5:07 PM
23 years of data confirm the usefulness of PSA screening.
#cancer #prostate #oncology
t.co/TvYDXQB1da
#cancer #prostate #oncology
t.co/TvYDXQB1da
A meta-analysis of 96 studies shows that hair dye is correlated with an increased incidence of cancer.
#oncology #epidemiology
www.sciencedirect.com/science/arti...
#oncology #epidemiology
www.sciencedirect.com/science/arti...
Exploring the Association Between Hair Dye Use and Human Cancers: A Systematic Review
The global hair color market is valued over 23 billion dollars with over two billion in sales in the United States. Permanent hair dye accounts for ap…
www.sciencedirect.com
October 31, 2025 at 5:06 PM
A meta-analysis of 96 studies shows that hair dye is correlated with an increased incidence of cancer.
#oncology #epidemiology
www.sciencedirect.com/science/arti...
#oncology #epidemiology
www.sciencedirect.com/science/arti...