Adam Stevens
@ajstevens.bsky.social
Reposted by Adam Stevens
Our latest collaborative paper with David Baker's lab is now live in Cell Biomaterials (@cp-cellbiomat.bsky.social, Cell Press)! Check out "Stimuli-triggered Formation of De Novo-designed Protein Biomaterials"!
🔓 : www.cell.com/cell-biomate...
🔓 : www.cell.com/cell-biomate...
October 20, 2025 at 10:46 PM
Our latest collaborative paper with David Baker's lab is now live in Cell Biomaterials (@cp-cellbiomat.bsky.social, Cell Press)! Check out "Stimuli-triggered Formation of De Novo-designed Protein Biomaterials"!
🔓 : www.cell.com/cell-biomate...
🔓 : www.cell.com/cell-biomate...
Reposted by Adam Stevens
Our new paper entitled “Boolean Logic-gated Protein Presentation through Autonomously Compiled Molecular Topology” is now live at Nature Chemical Biology (@natchembio.nature.com)! Check it out!
📜: www.nature.com/articles/s41...
@uwnews.uw.edu feature write-up: www.washington.edu/news/2025/10...
📜: www.nature.com/articles/s41...
@uwnews.uw.edu feature write-up: www.washington.edu/news/2025/10...
October 13, 2025 at 4:22 PM
Our new paper entitled “Boolean Logic-gated Protein Presentation through Autonomously Compiled Molecular Topology” is now live at Nature Chemical Biology (@natchembio.nature.com)! Check it out!
📜: www.nature.com/articles/s41...
@uwnews.uw.edu feature write-up: www.washington.edu/news/2025/10...
📜: www.nature.com/articles/s41...
@uwnews.uw.edu feature write-up: www.washington.edu/news/2025/10...
Reposted by Adam Stevens
Singh, A., Thale, S., Leibner, T., Lamparter, L., Ricker, A., Nüsse, H., Klingauf, J., Galic, M., Ohlberger, M., & Matis, M. (2024). Dynamic interplay of microtubule and actomyosin forces drive tissue extension. Nature communications, 15(1), 3198. #EpithelialMechanics
buff.ly/Nwi5TVv
buff.ly/Nwi5TVv
October 13, 2025 at 7:02 PM
Singh, A., Thale, S., Leibner, T., Lamparter, L., Ricker, A., Nüsse, H., Klingauf, J., Galic, M., Ohlberger, M., & Matis, M. (2024). Dynamic interplay of microtubule and actomyosin forces drive tissue extension. Nature communications, 15(1), 3198. #EpithelialMechanics
buff.ly/Nwi5TVv
buff.ly/Nwi5TVv
Reposted by Adam Stevens
With deep sadness, we share that Prof. Jochen Guck, Director at the Max Planck Institute for the Science of Light passed away on October 3. His visionary work bridged physics and medicine. We have lost a brilliant scientist and dear friend.
mpl.mpg.de/news/article...
@fau.de
📸 Stephan Spangenberg
mpl.mpg.de/news/article...
@fau.de
📸 Stephan Spangenberg
October 8, 2025 at 1:26 PM
With deep sadness, we share that Prof. Jochen Guck, Director at the Max Planck Institute for the Science of Light passed away on October 3. His visionary work bridged physics and medicine. We have lost a brilliant scientist and dear friend.
mpl.mpg.de/news/article...
@fau.de
📸 Stephan Spangenberg
mpl.mpg.de/news/article...
@fau.de
📸 Stephan Spangenberg
Reposted by Adam Stevens
Harris, A. R., Peter, L., Bellis, J., Baum, B., Kabla, A. J., & Charras, G. T. (2012). Characterizing the mechanics of cultured cell monolayers. Proceedings of the National Academy of Sciences of the United States of America, #EpithelialMechanics doi.org/10.1073/pnas...
October 7, 2025 at 7:01 AM
Harris, A. R., Peter, L., Bellis, J., Baum, B., Kabla, A. J., & Charras, G. T. (2012). Characterizing the mechanics of cultured cell monolayers. Proceedings of the National Academy of Sciences of the United States of America, #EpithelialMechanics doi.org/10.1073/pnas...
Reposted by Adam Stevens
My very dear Jochen Guck, has just passed away and yet I cannot believe it 🥹
Jochen is one of the most brilliant scientist I had ever met, a human being with unlimited qualities, brave and caring, positive (always) and full of ressources, helpful and with - always - the best advices.
Jochen is one of the most brilliant scientist I had ever met, a human being with unlimited qualities, brave and caring, positive (always) and full of ressources, helpful and with - always - the best advices.
October 5, 2025 at 6:54 AM
My very dear Jochen Guck, has just passed away and yet I cannot believe it 🥹
Jochen is one of the most brilliant scientist I had ever met, a human being with unlimited qualities, brave and caring, positive (always) and full of ressources, helpful and with - always - the best advices.
Jochen is one of the most brilliant scientist I had ever met, a human being with unlimited qualities, brave and caring, positive (always) and full of ressources, helpful and with - always - the best advices.
Reposted by Adam Stevens
New in @ScienceMagazine, we report that dilated cardiomyopathy can be alleviated by preventing hypocontractility-induced fibroblast expansion! The story is a fun combination of advanced in vivo and biomaterial-based in vitro models. Check it out!
📜 : doi.org/10.1126/scie...
📜 : doi.org/10.1126/scie...
Preventing hypocontractility-induced fibroblast expansion alleviates dilated cardiomyopathy
Cardiomyocyte hypocontractility underlies inherited dilated cardiomyopathy (DCM). Yet, whether fibroblasts modify DCM phenotypes remains unclear despite their regulation of fibrosis, which strongly pr...
doi.org
September 12, 2025 at 7:46 PM
New in @ScienceMagazine, we report that dilated cardiomyopathy can be alleviated by preventing hypocontractility-induced fibroblast expansion! The story is a fun combination of advanced in vivo and biomaterial-based in vitro models. Check it out!
📜 : doi.org/10.1126/scie...
📜 : doi.org/10.1126/scie...
Reposted by Adam Stevens
Our new manuscript entitled "PhoCoil: A Photodegradable and Injectable Single-component Recombinant Protein Hydrogel for Minimally Invasive Delivery and Degradation" is now live at @ScienceAdvances!
Check it out here (🔓): www.science.org/doi/10.1126/...
Check it out here (🔓): www.science.org/doi/10.1126/...
PhoCoil: A photodegradable and injectable single-component recombinant protein hydrogel for minimally invasive delivery and degradation
PhoCoil is a genetically encoded hydrogel that enables noninvasive delivery and subsequent user-controlled photodegradation.
www.science.org
September 3, 2025 at 7:21 PM
Our new manuscript entitled "PhoCoil: A Photodegradable and Injectable Single-component Recombinant Protein Hydrogel for Minimally Invasive Delivery and Degradation" is now live at @ScienceAdvances!
Check it out here (🔓): www.science.org/doi/10.1126/...
Check it out here (🔓): www.science.org/doi/10.1126/...
Reposted by Adam Stevens
Are different cell types like oil and water? Over a century ago, researchers found that dissociated sponges and embryonic tissues can self-assemble into functional structures. Join me, @benswedlund.bsky.social to explore the differential adhesion hypothesis & its applications in tissue engineering!
August 31, 2025 at 12:00 PM
Are different cell types like oil and water? Over a century ago, researchers found that dissociated sponges and embryonic tissues can self-assemble into functional structures. Join me, @benswedlund.bsky.social to explore the differential adhesion hypothesis & its applications in tissue engineering!
Reposted by Adam Stevens
Stevens, A. J., Harris, A. R., Gerdts, J., Kim, K. H., Trentesaux, C., Ramirez, J. T., ... & Lim, W. A. (2023). Programming multicellular assembly with synthetic cell adhesion molecules. Nature, #EpithelialMechanics www.nature.com/articles/s41...
August 27, 2025 at 8:29 PM
Stevens, A. J., Harris, A. R., Gerdts, J., Kim, K. H., Trentesaux, C., Ramirez, J. T., ... & Lim, W. A. (2023). Programming multicellular assembly with synthetic cell adhesion molecules. Nature, #EpithelialMechanics www.nature.com/articles/s41...
Reposted by Adam Stevens
Tsai, T. Y. C., Sikora, M., Xia, P., Colak-Champollion, T., Knaut, H., Heisenberg, C. P., & Megason, S. G. (2020). An adhesion code ensures robust pattern formation during tissue morphogenesis. Science, #EpithelialMechanics doi.org/10.1126/scie...
August 27, 2025 at 8:00 AM
Tsai, T. Y. C., Sikora, M., Xia, P., Colak-Champollion, T., Knaut, H., Heisenberg, C. P., & Megason, S. G. (2020). An adhesion code ensures robust pattern formation during tissue morphogenesis. Science, #EpithelialMechanics doi.org/10.1126/scie...
Reposted by Adam Stevens
Nose, A., Nagafuchi, A., & Takeichi, M. (1988). Expressed recombinant cadherins mediate cell sorting in model systems. Cell, #EpithelialMechanics doi.org/10.1016/0092...
August 26, 2025 at 8:00 AM
Nose, A., Nagafuchi, A., & Takeichi, M. (1988). Expressed recombinant cadherins mediate cell sorting in model systems. Cell, #EpithelialMechanics doi.org/10.1016/0092...
Reposted by Adam Stevens
Steinberg, M. S. (1963). Reconstruction of tissues by dissociated cells: some morphogenetic tissue movements and the sorting out of embryonic cells may have a common explanation. Science, #EpithelialMechanics www.science.org/doi/10.1126/...
August 25, 2025 at 4:53 PM
Steinberg, M. S. (1963). Reconstruction of tissues by dissociated cells: some morphogenetic tissue movements and the sorting out of embryonic cells may have a common explanation. Science, #EpithelialMechanics www.science.org/doi/10.1126/...
Reposted by Adam Stevens
New paper online from our long-standing collaboration with @dremilygoldberg.bsky.social on lysine lactylation catalysed by HDACs! www.jbc.org/article/S002...
Class I histone deacetylases catalyze lysine lactylation
Metabolism and post-translational modifications (PTMs) are intrinsically linked and
the number of identified metabolites that can covalently modify proteins continues
to increase. This metabolism/PTM ...
www.jbc.org
August 18, 2025 at 10:16 PM
New paper online from our long-standing collaboration with @dremilygoldberg.bsky.social on lysine lactylation catalysed by HDACs! www.jbc.org/article/S002...
Reposted by Adam Stevens
Congratulations to @stefanosala89.bsky.social , with help from @shreya-c.bsky.social al on the optogenetic experiments, for the awesome story! Read the full preprint here: www.biorxiv.org/content/10.1... and thanks for listening!
LIM Domain Proteins link molecular and global tension by recognizing strained actin in adhesions
Mechanotransduction is fundamental to cell signaling and depends on force-sensitive adhesion proteins. How these proteins differentiate and integrate their responses to tension remains an open questio...
www.biorxiv.org
July 21, 2025 at 5:33 PM
Congratulations to @stefanosala89.bsky.social , with help from @shreya-c.bsky.social al on the optogenetic experiments, for the awesome story! Read the full preprint here: www.biorxiv.org/content/10.1... and thanks for listening!
Reposted by Adam Stevens
Cell-cell contacts orchestrate tissue assembly and diverse cellular interactions.
🎯But what mediates their intricate patterns?🤔
Join me, @feyzanar.bsky.social, in exploring the interplay of adhesion and subcellular mechanics in contact patterning.
🎯But what mediates their intricate patterns?🤔
Join me, @feyzanar.bsky.social, in exploring the interplay of adhesion and subcellular mechanics in contact patterning.
May 3, 2025 at 8:00 AM
Cell-cell contacts orchestrate tissue assembly and diverse cellular interactions.
🎯But what mediates their intricate patterns?🤔
Join me, @feyzanar.bsky.social, in exploring the interplay of adhesion and subcellular mechanics in contact patterning.
🎯But what mediates their intricate patterns?🤔
Join me, @feyzanar.bsky.social, in exploring the interplay of adhesion and subcellular mechanics in contact patterning.
Reposted by Adam Stevens
I'm thrilled to finally share my PhD work on understanding how Ca2+ signals regulate the protruding front of the cell. It’s been an incredible journey working alongside all the collaborators.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A TRPV4–dependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration
Cell migration is crucial for development and tissue homeostasis, while its dysregulation leads to severe pathologies. Cell migration is driven by the extension of actin–based lamellipodia protrusions...
www.biorxiv.org
March 30, 2025 at 12:44 PM
I'm thrilled to finally share my PhD work on understanding how Ca2+ signals regulate the protruding front of the cell. It’s been an incredible journey working alongside all the collaborators.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Adam Stevens
Excited to share our latest work on how Ca²⁺ regulates actin in cell protrusions—now available as a preprint on bioRxiv! 🎉 Huge congrats to Ernest Iu for leading the project, and a special thanks to our amazing collaborators!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A TRPV4–dependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration
Cell migration is crucial for development and tissue homeostasis, while its dysregulation leads to severe pathologies. Cell migration is driven by the extension of actin–based lamellipodia protrusions...
www.biorxiv.org
March 30, 2025 at 11:41 AM
Excited to share our latest work on how Ca²⁺ regulates actin in cell protrusions—now available as a preprint on bioRxiv! 🎉 Huge congrats to Ernest Iu for leading the project, and a special thanks to our amazing collaborators!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
I am excited to announce that in March, I will start my lab in the Department of Cancer Biology at the University of Pennsylvania Perelman School of Medicine @pennmedicine.bsky.social @penncancer.bsky.social
stevens.bio
stevens.bio
Stevens Lab
Stevens.bio
February 7, 2025 at 3:36 AM
I am excited to announce that in March, I will start my lab in the Department of Cancer Biology at the University of Pennsylvania Perelman School of Medicine @pennmedicine.bsky.social @penncancer.bsky.social
stevens.bio
stevens.bio
Reposted by Adam Stevens
The latest from Lim Lab at CDI out today in Cell! "Synthetic organizer cells guide development via spatial and biochemical instructions" led by star postdocs Toshi Yamada and Coralie Trentesaux
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Synthetic organizer cells guide development via spatial and biochemical instructions
Synthetic organizer cells, engineered to spatially self-assemble around stem cells, can be used to create specific morphogen gradients and systematically guide in vitro development.
www.cell.com
December 19, 2024 at 9:00 PM
The latest from Lim Lab at CDI out today in Cell! "Synthetic organizer cells guide development via spatial and biochemical instructions" led by star postdocs Toshi Yamada and Coralie Trentesaux
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...