Ahmed Shah
@ahmedshahmd.bsky.social
Soft Tissue Pathologist/Dermatopathologist at Alberta Health Services.
BST @MayoClinic | Dermatopathology @UCalgary | Diagnostic and Molecular Pathology McMaster U | Class 2018 @uoftmedicine | MSc. @WesternU | humanities, philosophy & fitness
🇨🇦 🇨🇦 🇨🇦 🇨🇦
BST @MayoClinic | Dermatopathology @UCalgary | Diagnostic and Molecular Pathology McMaster U | Class 2018 @uoftmedicine | MSc. @WesternU | humanities, philosophy & fitness
🇨🇦 🇨🇦 🇨🇦 🇨🇦
onlinelibrary.wiley.com/doi/epdf/10....
I thought I’d hop on the PRAME bandwagon from the soft tissue side, of course. PRAME not only lights up melanomas, it ghosts MMNST/GNETs/MITF-rearranged tumors, and occasionally wines and dines an EMPNST...
#BST #pathsky
I thought I’d hop on the PRAME bandwagon from the soft tissue side, of course. PRAME not only lights up melanomas, it ghosts MMNST/GNETs/MITF-rearranged tumors, and occasionally wines and dines an EMPNST...
#BST #pathsky
Diagnostic Utility of PRAME in Rare Melanoma Mimics: A Comparative Analysis Including GNET, MMNST, Epithelioid MPNST, and MITF‐Rearranged Melanocytic Tumors
Background Differentiating metastatic melanoma from histologic mimics such as malignant gastrointestinal neuroectodermal tumor (GNET), malignant melanotic nerve sheath tumor (MMNST), and epithelioid...
onlinelibrary.wiley.com
September 1, 2025 at 12:46 AM
onlinelibrary.wiley.com/doi/epdf/10....
I thought I’d hop on the PRAME bandwagon from the soft tissue side, of course. PRAME not only lights up melanomas, it ghosts MMNST/GNETs/MITF-rearranged tumors, and occasionally wines and dines an EMPNST...
#BST #pathsky
I thought I’d hop on the PRAME bandwagon from the soft tissue side, of course. PRAME not only lights up melanomas, it ghosts MMNST/GNETs/MITF-rearranged tumors, and occasionally wines and dines an EMPNST...
#BST #pathsky
Reposted by Ahmed Shah
I spoke with UN Secretary-General António Guterres today. In this time of rising conflict, Canada is ready to lead.
We will build coalitions, defend democracy, and stand up for our values on the world stage. As others step back from global leadership, Canada is stepping up.
We will build coalitions, defend democracy, and stand up for our values on the world stage. As others step back from global leadership, Canada is stepping up.
May 1, 2025 at 9:34 PM
I spoke with UN Secretary-General António Guterres today. In this time of rising conflict, Canada is ready to lead.
We will build coalitions, defend democracy, and stand up for our values on the world stage. As others step back from global leadership, Canada is stepping up.
We will build coalitions, defend democracy, and stand up for our values on the world stage. As others step back from global leadership, Canada is stepping up.
Just voted as a Canadian living abroad for Mark Carney’s Liberals @mark-carney.bsky.social
No to the maple MAGA copycats
🇨🇦🇨🇦🇨🇦
#MarkCarney #electionscanada #vote #canada
No to the maple MAGA copycats
🇨🇦🇨🇦🇨🇦
#MarkCarney #electionscanada #vote #canada
April 5, 2025 at 5:23 PM
Just voted as a Canadian living abroad for Mark Carney’s Liberals @mark-carney.bsky.social
No to the maple MAGA copycats
🇨🇦🇨🇦🇨🇦
#MarkCarney #electionscanada #vote #canada
No to the maple MAGA copycats
🇨🇦🇨🇦🇨🇦
#MarkCarney #electionscanada #vote #canada
www.sciencedirect.com/science/arti...
This article discusses the very rare intraosseous RMS harboring FET::TFCP2 or MEIS1::NCOA2 fusions.
Was a pleasuring writing this with @folpe-mn-st.bsky.social
This article discusses the very rare intraosseous RMS harboring FET::TFCP2 or MEIS1::NCOA2 fusions.
Was a pleasuring writing this with @folpe-mn-st.bsky.social
Rhabdomyosarcomas of Bone: An Update
www.sciencedirect.com
April 2, 2025 at 8:19 PM
www.sciencedirect.com/science/arti...
This article discusses the very rare intraosseous RMS harboring FET::TFCP2 or MEIS1::NCOA2 fusions.
Was a pleasuring writing this with @folpe-mn-st.bsky.social
This article discusses the very rare intraosseous RMS harboring FET::TFCP2 or MEIS1::NCOA2 fusions.
Was a pleasuring writing this with @folpe-mn-st.bsky.social
Reposted by Ahmed Shah
#PathSky Abdominal wall mall mass, 65M. Multinodular with thick fibrous septa. Bland spindled to ovoid cells surrounding prominent vessels. Microcystic, pseudoglandular spaces.
April 2, 2025 at 7:42 PM
#PathSky Abdominal wall mall mass, 65M. Multinodular with thick fibrous septa. Bland spindled to ovoid cells surrounding prominent vessels. Microcystic, pseudoglandular spaces.
Reposted by Ahmed Shah
#PathSky 84M with lung nodule, signed out as “adenocarcinoma, favor pulmonary origin”. There is supposed to be a bit of TTF1 expression, but it is subtle to say the least.
March 18, 2025 at 6:40 PM
#PathSky 84M with lung nodule, signed out as “adenocarcinoma, favor pulmonary origin”. There is supposed to be a bit of TTF1 expression, but it is subtle to say the least.
Reposted by Ahmed Shah
For better or for worse (worse), MEASLES are back, so here's a #skytorial on recognizing this once thought eradicated disease.
MEASLES: a tutorial!
#dermsky #medsky #MedEd
1/
MEASLES: a tutorial!
#dermsky #medsky #MedEd
1/
March 2, 2025 at 1:13 PM
For better or for worse (worse), MEASLES are back, so here's a #skytorial on recognizing this once thought eradicated disease.
MEASLES: a tutorial!
#dermsky #medsky #MedEd
1/
MEASLES: a tutorial!
#dermsky #medsky #MedEd
1/
Reposted by Ahmed Shah
#PathSky I’ve been bad about posting, my apologies. Ok, 86M with destructive T12 lesion. Sent in to subclassify the malignant spindle cell lesion. Keratins, melanocytic markers, muscle markers, SATB2 negative.
March 10, 2025 at 7:09 PM
#PathSky I’ve been bad about posting, my apologies. Ok, 86M with destructive T12 lesion. Sent in to subclassify the malignant spindle cell lesion. Keratins, melanocytic markers, muscle markers, SATB2 negative.
Reposted by Ahmed Shah
#PathSky I usually like to show cases where the morphology makes sense of the molecular, but here’s one where you kind of need the molecular. Axillary mass, 9 month male. Very hyalinized, infiltration of fat, cracking artifact. Strongly CD34-pos. Giant cell fibroblastoma?
February 24, 2025 at 8:32 PM
#PathSky I usually like to show cases where the morphology makes sense of the molecular, but here’s one where you kind of need the molecular. Axillary mass, 9 month male. Very hyalinized, infiltration of fat, cracking artifact. Strongly CD34-pos. Giant cell fibroblastoma?
🚨 1st reported primary cutaneous spindle cell sarcoma with FN1-rearrangement. Unlike other FN1-fusion tumors like PMTs and CCMNs, this one truly stands apart histologically.
Read more also with clinical and radiological images: pubmed.ncbi.nlm.nih.gov/39945063/
#pathsky #bst #dermsky #dermpath
Read more also with clinical and radiological images: pubmed.ncbi.nlm.nih.gov/39945063/
#pathsky #bst #dermsky #dermpath
February 15, 2025 at 1:56 PM
🚨 1st reported primary cutaneous spindle cell sarcoma with FN1-rearrangement. Unlike other FN1-fusion tumors like PMTs and CCMNs, this one truly stands apart histologically.
Read more also with clinical and radiological images: pubmed.ncbi.nlm.nih.gov/39945063/
#pathsky #bst #dermsky #dermpath
Read more also with clinical and radiological images: pubmed.ncbi.nlm.nih.gov/39945063/
#pathsky #bst #dermsky #dermpath
The Dark Age, round 2
February 8, 2025 at 11:39 PM
The Dark Age, round 2
Reposted by Ahmed Shah
Executive wants to frame the NIH indirects cut as $4B in savings.
But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.
But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.
Direct Economic Contributions
NIH directly supports the economy through investments in research institutions and job formation.
www.nih.gov
February 8, 2025 at 3:08 AM
Executive wants to frame the NIH indirects cut as $4B in savings.
But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.
But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.
Check out our paper reviewing current practices of pathologist-driven reflex biomarker testing for #melanoma across #canada.
We propose a standardized minimum criteria for reflex testing.
#dermpath #pathology #dermatology
We propose a standardized minimum criteria for reflex testing.
#dermpath #pathology #dermatology
February 2, 2025 at 10:01 PM
Check out our paper reviewing current practices of pathologist-driven reflex biomarker testing for #melanoma across #canada.
We propose a standardized minimum criteria for reflex testing.
#dermpath #pathology #dermatology
We propose a standardized minimum criteria for reflex testing.
#dermpath #pathology #dermatology
Reposted by Ahmed Shah
#PathSky 43M with a giant, pendulous mass of the inner thigh. The outside clinician and pathologist were concerned for WDL, but their MDM2 FISH was negative. Certainly there is nature fat with fibrous septae and an increased number of somewhat atypical stromal cells? False negative FISH?
January 30, 2025 at 8:15 PM
#PathSky 43M with a giant, pendulous mass of the inner thigh. The outside clinician and pathologist were concerned for WDL, but their MDM2 FISH was negative. Certainly there is nature fat with fibrous septae and an increased number of somewhat atypical stromal cells? False negative FISH?
Reposted by Ahmed Shah
I asked RFK Jr. a simple question:
January 29, 2025 at 7:32 PM
I asked RFK Jr. a simple question:
Reposted by Ahmed Shah
Ladies and gentlemen: we did it
In email to X staff, Musk says "user growth is stagnant, revenue is unimpressive, and we're barely breaking even"; sources: banks plan to sell their debt in X (Wall Street Journal)
Main Link | Techmeme Permalink
Main Link | Techmeme Permalink
January 24, 2025 at 8:52 PM
Ladies and gentlemen: we did it
Reposted by Ahmed Shah
this Friday 🎉 - please join us
#dermpath #dermtwitter #pathtwitter #dermatologia #dermatology #pathology
#dermatopathology
& if anyone would be interested in speaking to your Canadian colleagues sans tariffs, please reach out! #dermpath and where we intersect #gynepath #pedipath also welcome 🤝💥🇨🇦🔬
#dermpath #dermtwitter #pathtwitter #dermatologia #dermatology #pathology
#dermatopathology
& if anyone would be interested in speaking to your Canadian colleagues sans tariffs, please reach out! #dermpath and where we intersect #gynepath #pedipath also welcome 🤝💥🇨🇦🔬
January 27, 2025 at 5:03 PM
this Friday 🎉 - please join us
#dermpath #dermtwitter #pathtwitter #dermatologia #dermatology #pathology
#dermatopathology
& if anyone would be interested in speaking to your Canadian colleagues sans tariffs, please reach out! #dermpath and where we intersect #gynepath #pedipath also welcome 🤝💥🇨🇦🔬
#dermpath #dermtwitter #pathtwitter #dermatologia #dermatology #pathology
#dermatopathology
& if anyone would be interested in speaking to your Canadian colleagues sans tariffs, please reach out! #dermpath and where we intersect #gynepath #pedipath also welcome 🤝💥🇨🇦🔬
Reposted by Ahmed Shah
#PathSky 15F, thumb mass. There are no relevant positive immunostains. However, FISH for DDIT3 amplification (not rearrangement) is positive. This is an excellent example of a GLI1-amplified sarcoma. This is a great paper from the MSKCC group. pubmed.ncbi.nlm.nih.gov/38934567/
December 20, 2024 at 6:33 PM
#PathSky 15F, thumb mass. There are no relevant positive immunostains. However, FISH for DDIT3 amplification (not rearrangement) is positive. This is an excellent example of a GLI1-amplified sarcoma. This is a great paper from the MSKCC group. pubmed.ncbi.nlm.nih.gov/38934567/
Reposted by Ahmed Shah
#PathSky Cystic leg mass, 31F. The outside pathologist thought this was probably a BFH/DF, but wasn’t sure how to explain the epithelium. This is a siderotic BFH with “adnexal induction”. You can get basically any imaginable adnexal proliferation. Siderophages are a good BFH clue.
December 5, 2024 at 4:30 PM
#PathSky Cystic leg mass, 31F. The outside pathologist thought this was probably a BFH/DF, but wasn’t sure how to explain the epithelium. This is a siderotic BFH with “adnexal induction”. You can get basically any imaginable adnexal proliferation. Siderophages are a good BFH clue.
Reposted by Ahmed Shah
#PathSky Since I was on vacation, here’s one more. 47M, arm mass. Don’t overthink it- it’s just an undifferentiated pleomorphic sarcoma. But- the outside was concerned for LMS, because of the diffusely positive caldesmon. Oddly, all the other muscle markers were negative. Can you explain this?
December 20, 2024 at 7:28 PM
#PathSky Since I was on vacation, here’s one more. 47M, arm mass. Don’t overthink it- it’s just an undifferentiated pleomorphic sarcoma. But- the outside was concerned for LMS, because of the diffusely positive caldesmon. Oddly, all the other muscle markers were negative. Can you explain this?
Reposted by Ahmed Shah
#PathSky 32M with extra-axial, dural-based, frontoparietal mass. Clearly malignant epithelioid cells arranged in cords and nests in a sclerotic background. Looks a lot like a sclerosing epithelioid fibrosarcoma, and it is strongly MUC4-positive. So, we’re done, right?
January 8, 2025 at 5:13 PM
#PathSky 32M with extra-axial, dural-based, frontoparietal mass. Clearly malignant epithelioid cells arranged in cords and nests in a sclerotic background. Looks a lot like a sclerosing epithelioid fibrosarcoma, and it is strongly MUC4-positive. So, we’re done, right?