✅ Endpoint met
👉mPFS 11.2(C)vs17.5 months(I)
👉NO detrimental effect on OS
👉DCR 94.2%(C)vs91%(I)
👉Reduced toxicity
ascopubs.org/doi/pdf/10.1...
Neoadjuvant #IO in #stcsm #esocsm using #treme + #durva ~60% pCR
12m 🚫🔪#survival ~ 64%.
#Ph3 data needed, but organ preservation possible!
🔗: sciencedirect.com/science/arti...
For #colorectalcancer, there are many great abstracts-so this is just a few to🔦:
Pre-op:
1⃣@CQvortrup🗣️a Single-cycle of neoadj pembro for Stage I-III MMRdef CRC, Oral Abs 19
2⃣@jonathanloree🗣️using ctDNA🩸to support Non-Op management in rectal cancer, Oral Abs 20
For #colorectalcancer, there are many great abstracts-so this is just a few to🔦:
Pre-op:
1⃣@CQvortrup🗣️a Single-cycle of neoadj pembro for Stage I-III MMRdef CRC, Oral Abs 19
2⃣@jonathanloree🗣️using ctDNA🩸to support Non-Op management in rectal cancer, Oral Abs 20
The BIG trial in #colorectalcancer will be Scott Kopetz 🗣️BREAKWATER, the 1st line R-Ph3 trial of encorafenib + cetuximab + chemotherapy in BRAF V600E-mutant met CRC, Oral Abs 16
The BIG trial in #colorectalcancer will be Scott Kopetz 🗣️BREAKWATER, the 1st line R-Ph3 trial of encorafenib + cetuximab + chemotherapy in BRAF V600E-mutant met CRC, Oral Abs 16
And 3 immunotherapy trials in #MCRC:
1⃣Thierry Andre🗣️the LBA of Ipi-Nivo vs Nivo of dMMR mCRC, ABS LBA143
2⃣ Marwan Fakih🗣️a Ph2 trial of BOT +/- Bal in MSS mCRC (no liver mets), Oral Abs 23
3⃣Joel R Hecht🗣️a Ph2 trial of a personalized Neo-Ant IO for MSS CRC, Abs LBA13
And 3 immunotherapy trials in #MCRC:
1⃣Thierry Andre🗣️the LBA of Ipi-Nivo vs Nivo of dMMR mCRC, ABS LBA143
2⃣ Marwan Fakih🗣️a Ph2 trial of BOT +/- Bal in MSS mCRC (no liver mets), Oral Abs 23
3⃣Joel R Hecht🗣️a Ph2 trial of a personalized Neo-Ant IO for MSS CRC, Abs LBA13
top 3 trials in #crcsm
🥇: NICHE-2 - 99% #ORR, 100% 3-year DFS in dMMR colon cancer with ⬇️ #tox
🥈: KRYSTAL-1 - adagrasib in KRAS G12C cancers ➡️ FDA approval + cetux
🥉: TransMet - transplant + 💉 improves 5y #OS
🔗: nature.com/articles/s41...
👉⬇️recurrence 12% vs 21%(HR=0.51,p0.09),significant in EREG/AREG ⬆️
👉⬆️TOX G3 diarrhoea and rash
👉⬇️recurrence 12% vs 21%(HR=0.51,p0.09),significant in EREG/AREG ⬆️
👉⬆️TOX G3 diarrhoea and rash
doi.org/10.1038/s415... @natmedicine.bsky.social
✅The pCR rates were 27.1%, 32.7% and 14.0% for experiment groups A and B and the control group C, respectively
doi.org/10.1038/s415... @natmedicine.bsky.social
✅The pCR rates were 27.1%, 32.7% and 14.0% for experiment groups A and B and the control group C, respectively
Finally, two additional abstracts to watch for in #cholangiocarcinoma:
1⃣Dr. Priyanshi Shah🗣️Long-term outcomes for MSI-H BTC patients on immunotherapy, Abs 592; Post#C18
2⃣Dr. Christos Fountzilas🗣️🎯FGFR in the Ph2 trial of Tinengotinib for BTC Pts, Abs 608; Post#D9
Finally, two additional abstracts to watch for in #cholangiocarcinoma:
1⃣Dr. Priyanshi Shah🗣️Long-term outcomes for MSI-H BTC patients on immunotherapy, Abs 592; Post#C18
2⃣Dr. Christos Fountzilas🗣️🎯FGFR in the Ph2 trial of Tinengotinib for BTC Pts, Abs 608; Post#D9
3⃣abstracts🔬outcomes of Pts with specific🧬alterations in #cholangiocarcinoma:
1⃣&2⃣look at MDM2amp BTC:
➡️Dr. Iyer, Abs 544; Post#A22
➡️Teresa Macarulla, Abs 615, Post#D16
3⃣Richard Kim🗣️Real-World OS in BTC Pts with IDH1mut or FGFR2fus + BTC, Abs 548; Post#A26
3⃣abstracts🔬outcomes of Pts with specific🧬alterations in #cholangiocarcinoma:
1⃣&2⃣look at MDM2amp BTC:
➡️Dr. Iyer, Abs 544; Post#A22
➡️Teresa Macarulla, Abs 615, Post#D16
3⃣Richard Kim🗣️Real-World OS in BTC Pts with IDH1mut or FGFR2fus + BTC, Abs 548; Post#A26
Starting with #PancreaticCancer and Ras⛔️
Actually only2⃣titles I saw:
1⃣Ignacio Garrido-Laguna🗣️ctDNA🩸changes in the Ph1 trial of the Ras(on)⛔️RMC-6236 Abs 722; Poster#H10
2⃣Alex Spira🗣️a Ph1 trial of the G12D specific⛔️RMC-9805 Abs 724; Poster#H12
ESSO, ESGO, MASCC & SIOG
invite you to the #OncoAlertColloquium
REGISTER for FREE HERE👉 buff.ly/3CChgre
February 3-9, 2025 💯% Virtual & Interactive
@erikahamilton9.bsky.social
@drsgraff.bsky.social
@drjnaidoo.bsky.social
@hoperugo.bsky.social
ESSO, ESGO, MASCC & SIOG
invite you to the #OncoAlertColloquium
REGISTER for FREE HERE👉 buff.ly/3CChgre
February 3-9, 2025 💯% Virtual & Interactive
@erikahamilton9.bsky.social
@drsgraff.bsky.social
@drjnaidoo.bsky.social
@hoperugo.bsky.social
by Dr.Dustin Deming on #JNCCN
jnccn.org/view/journal... @oncoalert.bsky.social @oncodaily.bsky.social @medicalwatch.bsky.social
by Dr.Dustin Deming on #JNCCN
jnccn.org/view/journal... @oncoalert.bsky.social @oncodaily.bsky.social @medicalwatch.bsky.social
The Landscape of @fda.gov drug approvals in 2024. 30% Oncology novel drugs !
The Landscape of @fda.gov drug approvals in 2024. 30% Oncology novel drugs !
@medicalwatch.bsky.social
@katesears.bsky.social
@medicalwatch.bsky.social
@katesears.bsky.social
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Wishing you hashtag#MerryChrismas2024 & Happy Holidays from All of us at OncoAlert 🚨
@elisaagostinetto.bsky.social
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@lymphomadoc.bsky.social
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@stephenvliu.bsky.social
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@erikahamilton9.bsky.social
Wishing you hashtag#MerryChrismas2024 & Happy Holidays from All of us at OncoAlert 🚨
@elisaagostinetto.bsky.social
@drjnaidoo.bsky.social
@lymphomadoc.bsky.social
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@ascocancer.bsky.social
oncodaily.com/blog/asco-21...
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