@aaltonenlab.bsky.social
The Tumor Genomics Group (Aaltonen Lab) focuses on human tumor susceptibility as well as somatic cancer genomics.
Reposted
Once a cancer cell starts accelerating its growth, how can we stop it? During their Ph.D. work, Zhijia Wang (Taipale Group) investigated how small molecule inhibitors might act as brakes in this process.
Read more about their work here: tumorgenetics.blog/2025/05/23/u...
Read more about their work here: tumorgenetics.blog/2025/05/23/u...
Unlocking Cancer’s Weakness: Targeting Transcriptional CDKs with Small Molecule Inhibitors
The research by Zhijia Wang focuses on identifying small-molecule inhibitors targeting transcriptional CDKs (CDK7, 9, 12) in cancer cells to halt uncontrolled growth. By screening various compounds…
tumorgenetics.blog
May 28, 2025 at 11:00 AM
Once a cancer cell starts accelerating its growth, how can we stop it? During their Ph.D. work, Zhijia Wang (Taipale Group) investigated how small molecule inhibitors might act as brakes in this process.
Read more about their work here: tumorgenetics.blog/2025/05/23/u...
Read more about their work here: tumorgenetics.blog/2025/05/23/u...
Reposted
Our newest paper by Joonas Uusi-Mäkelä et al. about the lncRNAs and their relations on growth and prognosis in diffuse gliomas is out now in Scientific Reports. Study was done in collaboration with NykterLab. www.nature.com/articles/s41...
May 12, 2025 at 10:53 AM
Our newest paper by Joonas Uusi-Mäkelä et al. about the lncRNAs and their relations on growth and prognosis in diffuse gliomas is out now in Scientific Reports. Study was done in collaboration with NykterLab. www.nature.com/articles/s41...
Chromatin state origins of uterine leiomyoma published! Check it out! #uterineleiomyoma #chromatin #GWAS
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Chromatin state origins of uterine leiomyoma - Nature Communications
The chromatin state origins of uterine leiomyoma (UL) remain to be explored. Here, the authors integrate data from genome-wide association studies and deep regulatory genomics data from myometrium and...
www.nature.com
May 9, 2025 at 10:18 AM
Chromatin state origins of uterine leiomyoma published! Check it out! #uterineleiomyoma #chromatin #GWAS
www.nature.com/articles/s41...
www.nature.com/articles/s41...
PhD student, Vilja Jokinen from the Tumor Genomics Research group standing next to her poster at this years American Association for Cancer Research (AACR) meeting in Chicago, Illinois! @coeintg.bsky.social #cancerresearch
May 8, 2025 at 10:40 AM
PhD student, Vilja Jokinen from the Tumor Genomics Research group standing next to her poster at this years American Association for Cancer Research (AACR) meeting in Chicago, Illinois! @coeintg.bsky.social #cancerresearch
Reposted
Exciting new work from Zhiyuan Xie et al. in the Taipale Group exploring the intricacies of transcription factor interactions in gene regulation.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
DNA-guided transcription factor interactions extend human gene regulatory code - Nature
A large-scale analysis of DNA-bound transcription factors (TFs) shows how the presence of DNA markedly affects the landscape of TF interactions, and identifies composite motifs that are recognized by ...
www.nature.com
April 24, 2025 at 9:35 AM
Exciting new work from Zhiyuan Xie et al. in the Taipale Group exploring the intricacies of transcription factor interactions in gene regulation.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New paper published! Structural features of somatic and germline retrotransposition events in humans. Congrats Päivi et al!👏 @coeintg.bsky.social
mobilednajournal.biomedcentral.com/articles/10....
mobilednajournal.biomedcentral.com/articles/10....
Structural features of somatic and germline retrotransposition events in humans - Mobile DNA
Background Transposons are DNA sequences able to move or copy themselves to other genomic locations leading to insertional mutagenesis. Although transposon-derived sequences account for half of the hu...
mobilednajournal.biomedcentral.com
April 23, 2025 at 11:10 AM
New paper published! Structural features of somatic and germline retrotransposition events in humans. Congrats Päivi et al!👏 @coeintg.bsky.social
mobilednajournal.biomedcentral.com/articles/10....
mobilednajournal.biomedcentral.com/articles/10....
Reposted
Genes aren't the only part of chromosomes that can change in cancer cells. Doctoral researcher Joonas Uusi-Mäkelä (Nykter Lab) shares some recent results about how chromatin compactness, or accessibility, also changes in prostate cancer.
tumorgenetics.blog/2025/04/10/r...
tumorgenetics.blog/2025/04/10/r...
Room For Improvement – How Does the Accessibility of Chromatin Change in Prostate Cancer?
Prostate cancer, prevalent in Western men, often leads to castration-resistant forms, posing treatment challenges. A study examines chromatin accessibility changes during cancer progression using p…
tumorgenetics.blog
April 11, 2025 at 11:50 AM
Genes aren't the only part of chromosomes that can change in cancer cells. Doctoral researcher Joonas Uusi-Mäkelä (Nykter Lab) shares some recent results about how chromatin compactness, or accessibility, also changes in prostate cancer.
tumorgenetics.blog/2025/04/10/r...
tumorgenetics.blog/2025/04/10/r...