Jonathan Coxhead
@4130chromo.bsky.social
Head of #Genomics Core Facility at NCL ๐งฌ Single-Cell ๐งฌ Spatial-Transcriptomics ๐งฌ Next-Generation Sequencing ๐งฌ MTBing ๐ต๐ปโโ๏ธ Dad & Husband ๐จโ๐ฉโ๐งโ๐ฆ | โฝ๐ดโช SAFC ๐ซ | ๐ฆ own views.
Given it's a challenge for them to run the US, day-to-day, this doesn't surprisee in the slightest.
January 4, 2026 at 8:51 PM
Given it's a challenge for them to run the US, day-to-day, this doesn't surprisee in the slightest.
Skippy Common - that's from another lifetime, for me.
January 4, 2026 at 8:43 PM
Skippy Common - that's from another lifetime, for me.
Reposted by Jonathan Coxhead
Let's get you cleaned up and ready for another year's worth of office brews!
January 3, 2026 at 10:27 AM
Let's get you cleaned up and ready for another year's worth of office brews!
Review | Interpretation, extrapolation and perturbation of single cells www.nature.com/articles/s41...
Interpretation, extrapolation and perturbation of single cells - Nature Reviews Genetics
Causal and mechanistic modelling strategies, which aim to infer causeโeffect relationships, provide insights into cellular responses to perturbations. The authors review computational approaches that ...
www.nature.com
January 2, 2026 at 9:11 PM
Review | Interpretation, extrapolation and perturbation of single cells www.nature.com/articles/s41...
Review | From bulk RNA sequencing to spatial transcriptomics: a comparative review of differential gene expression analysis methods link.springer.com/article/10.1...
From bulk RNA sequencing to spatial transcriptomics: a comparative review of differential gene expression analysis methods - Human Genomics
Human Genomics - Transcriptome analysis is essential to dissect the molecular mechanisms underlying phenotypic differences and disease mechanisms. Traditionally, microarrays were used, but RNA...
link.springer.com
January 2, 2026 at 8:46 PM
Review | From bulk RNA sequencing to spatial transcriptomics: a comparative review of differential gene expression analysis methods link.springer.com/article/10.1...
Review | Beyond the gene: decoding alternative isoforms www.cell.com/trends/genet...
Beyond the gene: decoding alternative isoforms
It has been well-established that the vast majority of human genes are expressed not
as a single mRNA transcript but rather as a series of many distinct mRNAs due to processes
including alternative sp...
www.cell.com
January 2, 2026 at 8:38 PM
Review | Beyond the gene: decoding alternative isoforms www.cell.com/trends/genet...
AlphaGenome: a Swiss-army knife for exploring non-coding DNA www.cell.com/trends/genet...
AlphaGenome: a Swiss-army knife for exploring non-coding DNA
AlphaGenome, recently announced in a preprint by Avsec et al., is Google DeepMindโs
powerful โSwiss army knifeโ for predicting molecular effects from non-coding DNA.
Remarkably, it does so with base-p...
www.cell.com
January 2, 2026 at 8:36 PM
AlphaGenome: a Swiss-army knife for exploring non-coding DNA www.cell.com/trends/genet...
Review | Challenges in Clinical Translation of Polygenic Risk Score Analyses: A Systematic Review www.gimjournal.org/article/S109...
Challenges in Clinical Translation of Polygenic Risk Score Analyses: A Systematic Review
The translation of polygenic risk score (PRS) analyses into clinical practice is gaining
momentum, yet remains limited by multiple implementation barriers studied across fragmented
research lines. Thi...
www.gimjournal.org
January 2, 2026 at 8:30 PM
Review | Challenges in Clinical Translation of Polygenic Risk Score Analyses: A Systematic Review www.gimjournal.org/article/S109...
Generative AI creates synthetic regulatory DNA sequences for precision gene control www.nature.com/articles/s41...
Generative AI creates synthetic regulatory DNA sequences for precision gene control - Nature Genetics
We developed DNA-Diffusion, a generative artificial intelligence (AI) method that creates synthetic regulatory elements showing enhanced activity. Multiple synthetic elements demonstrated superior cel...
www.nature.com
January 2, 2026 at 8:20 PM
Generative AI creates synthetic regulatory DNA sequences for precision gene control www.nature.com/articles/s41...
Cost-comparison of resequencing versus archival data methods for periodic reanalysis of genomic data in rare diseases diagnosis: A UK pilot analysis www.sciencedirect.com/science/arti...
Cost-comparison of resequencing versus archival data methods for periodic reanalysis of genomic data in rare diseases diagnosis: A UK pilot analysis
Periodic reanalysis of genome sequence data in rare diseases to improve diagnostic rates is recommended every 18-months. However, cost can be a major โฆ
www.sciencedirect.com
January 2, 2026 at 8:12 PM
Cost-comparison of resequencing versus archival data methods for periodic reanalysis of genomic data in rare diseases diagnosis: A UK pilot analysis www.sciencedirect.com/science/arti...
๐ต Radiohead - OK Computer ๐๐
January 2, 2026 at 7:45 PM
๐ต Radiohead - OK Computer ๐๐
Fishing fleets as ecosystem sentinels www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
January 2, 2026 at 7:36 PM
Fishing fleets as ecosystem sentinels www.pnas.org/doi/10.1073/...
Sequencing every UK newborn: why cold storage economics should shape policy jmg.bmj.com/content/earl...
Sequencing every UK newborn: why cold storage economics should shape policy
Whole-genome sequencing (WGS) for every UK newborn is hailed as a leap towards lifelong personalised medicine, yet policymakers have scarcely examined the informatics iceberg beneath the initiative: w...
jmg.bmj.com
January 2, 2026 at 7:20 PM
Sequencing every UK newborn: why cold storage economics should shape policy jmg.bmj.com/content/earl...
Bridging the dimensional gap from planar spatial transcriptomics to 3D cell atlases www.nature.com/articles/s41...
(can't help thinking about Adidas trainers)
(can't help thinking about Adidas trainers)
Bridging the dimensional gap from planar spatial transcriptomics to 3D cell atlases - Nature Methods
SpatialZ generates virtual single-cell spatial transcriptomics slices between experimentally measured sections, enabling accurate and efficient building of 3D cell atlases of different tissues.
www.nature.com
January 2, 2026 at 7:10 PM
Bridging the dimensional gap from planar spatial transcriptomics to 3D cell atlases www.nature.com/articles/s41...
(can't help thinking about Adidas trainers)
(can't help thinking about Adidas trainers)
Evaluation of computational methods for reconstruction of human viral DNA genomes academic.oup.com/gigascience/...
An evaluation of computational methods for reconstruction of human viral DNA genomes
AbstractBackground. The increasing availability of viral sequencing data has led to the emergence of many optimized viral genome reconstruction tools. Give
academic.oup.com
January 2, 2026 at 6:59 PM
Evaluation of computational methods for reconstruction of human viral DNA genomes academic.oup.com/gigascience/...
Transcript-guided targeted cell enrichment for scalable single-nucleus RNA sequencing www.cell.com/cell-genomic...
Transcript-guided targeted cell enrichment for scalable single-nucleus RNA sequencing
EnrichSci is an antibody-free, targeted single-nucleus RNA sequencing method that
enables efficient profiling of rare cell types with full gene-body coverage. Applied
to oligodendrocytes in the brain,...
www.cell.com
January 2, 2026 at 6:53 PM
Transcript-guided targeted cell enrichment for scalable single-nucleus RNA sequencing www.cell.com/cell-genomic...
I almost quit my Ph.D. A lab mate gave me the confidence to continue www.science.org/content/arti...
I almost quit my Ph.D. A lab mate gave me the confidence to continue
Now, helping students find their way in science is the most rewarding part of the job, this professor writes
www.science.org
January 2, 2026 at 6:49 PM
I almost quit my Ph.D. A lab mate gave me the confidence to continue www.science.org/content/arti...
๐ต Slowdive - Souvlaki ๐๐
January 2, 2026 at 6:28 PM
๐ต Slowdive - Souvlaki ๐๐
Reposted by Jonathan Coxhead
Should you still have quite a few clementines about the place, you might be particularly interested in #RecipeOfTheDay, even if you did make (as I did) this Clementine Cake over Christmas. Its bright sunniness is just whatโs needed now, I rather feel! www.nigella.com/recipes/clem...
Clementine Cake
This, an adaption of Claudia Roden's magnificent orange and almond cake, is a wonderfully damp, dense and aromatic flourless cake: it tastes like one of those sponges you drench, while cooling, with s...
www.nigella.com
January 2, 2026 at 11:23 AM
Should you still have quite a few clementines about the place, you might be particularly interested in #RecipeOfTheDay, even if you did make (as I did) this Clementine Cake over Christmas. Its bright sunniness is just whatโs needed now, I rather feel! www.nigella.com/recipes/clem...
First ride of 2026 - cold but pure bliss โ๏ธโ๏ธ๐ตโโ๏ธ
Lots of Fieldfare and Redwing, more than I can remember seeing in a long time.
The clouds off the coast looked very 'snow like'
Lots of Fieldfare and Redwing, more than I can remember seeing in a long time.
The clouds off the coast looked very 'snow like'
January 2, 2026 at 3:30 PM
First ride of 2026 - cold but pure bliss โ๏ธโ๏ธ๐ตโโ๏ธ
Lots of Fieldfare and Redwing, more than I can remember seeing in a long time.
The clouds off the coast looked very 'snow like'
Lots of Fieldfare and Redwing, more than I can remember seeing in a long time.
The clouds off the coast looked very 'snow like'
๐ Roast Beef ๐
January 1, 2026 at 1:46 PM
๐ Roast Beef ๐