Mark A. Rubin | Lightnews

Mark A Rubin

@marubin1.bsky.social

43 followers 9 following 6 posts

Precision Oncology researcher in Switzerland with special interest in epigenetics and splicing.

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Biology 90%

Medicine 10%

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Reposted by Mark A. Rubin

ESMO - European Society for Medical Oncology @myesmo.bsky.social · 7d

📣Updated ESMO #ClinicalPracticeGuideline on advanced and metastatic #ProstateCancer:
✅ Substantial advances in castration-sensitive & -resistant prostate cancer
✅ Updated algorithms & recommendations reflecting latest clinical data
#ESMOGuidelines Christopher Sweeney

🔗 https://ow.ly/E4ov50Yc8e2

Mark A Rubin @marubin1.bsky.social · 9d

🧬 New preprint out!
Dilara Akhoundova and team identify AURKA as a synthetic lethal vulnerability in FANCA-deficient cancers using complementary CRISPR and drug screens.
🔗 doi.org/10.64898/202...
#PrecisionOncology #SyntheticLethality #FANCA #AURKA #CancerGenomics

Reposted by Mark A. Rubin

American Association for Cancer Research (AACR) @theaacr.bsky.social · 25d

Molecular Cancer Research editor Massimo Loda, Franklin W. Huang, Michael C. Haffner, and Irene Paassen discussed "Genomics and Epigenomics" in a plenary session at the AACR Special Conference on Innovations in Prostate Cancer Research and Treatment.
#AACRprostate26 @aacrjournals.bsky.social

Mark A Rubin @marubin1.bsky.social · 28d

Can we help men with hormone-refractory #ProstateCancer through personalized epigenetic therapy? Our new study using patient-derived organoids reveals a targetable weakness in a WNT-driven subtype. @genentech.bsky.social @medfacultyunibe.bsky.social @unibe.ch @pmbern.bsky.social tinyurl.com/2tkn3hwh

Reposted by Mark A. Rubin

DBMR University Bern @dbmr-unibe.bsky.social · Jan 6

New @natmed.nature.com News & Views by @marubin1.bsky.social and Dr. Irene Paassen on why #PrecisionOncology must go beyond genomics. @medfacultyunibe.bsky.social @pmbern.bsky.social
tinyurl.com/2zvdvmy6

Reposted by Mark A. Rubin, Chris Parker

ESMO - European Society for Medical Oncology @myesmo.bsky.social · Dec 18

📣 Updated ESMO #ClinicalPracticeGuideline on local & locoregional #ProstateCancer:
✅New imaging modalities: Improved diagnosis, staging & risk stratification
✅Updated algorithms: less over-Tx & fewer side-effects
#Oncology #UroOncology #CancerCare #ESMOGuidelines

🔗 https://ow.ly/jwA650XLs1q

Mark A Rubin @marubin1.bsky.social · Dec 14

Excited to share new preprint on the minor spliceosome in cancer! Targeting U6atac disrupts DNA repair and sensitizes prostate & breast tumors to radiation, cisplatin and PARP inhibitors—even beyond BRCA-mutant . bit.ly/48RnsI5 #DNARepair #ProstateCancer #BreastCancer #U6atac @theaacr.bsky.social

Mark A Rubin @marubin1.bsky.social · Nov 27

Congrats to Jia and Michael and team. This has been a major effort and we are learning so much about lineage plasticity www.nature.com/articles/s41....