Andrew Bass
@ajbass.bsky.social
Post-doc Wallace lab, PhD Storey lab
Environmental science
37%
Biology
30%
Andrew Bass
@ajbass.bsky.social
· Aug 25
Exploiting pleiotropy to enhance variant discovery with functional false discovery rates - Nature Computational Science
This study introduces a cost-effective strategy called surrogate functional false discovery rates to increase power in genome-wide association studies by leveraging genetic correlations (or pleiotropy...
www.nature.com
Excited to see our (w/ @chr1sw.bsky.social) work published in @natcomputsci.nature.com! We developed a new framework, surrogate functional false discovery rate (sffdr), that integrates summary statistics of related traits to improve power in GWASs.
Paper: www.nature.com/articles/s43...
Paper: www.nature.com/articles/s43...
Reposted by Andrew H. Bass
Exploiting pleiotropy to enhance variant discovery with functional false discovery rates https://www.medrxiv.org/content/10.1101/2024.09.24.24314276v1
The cost of acquiring participants for genome-wide association studies (GWAS) can limit sample sizes
www.medrxiv.org
Exploiting pleiotropy to enhance variant discovery with functional false discovery rates https://www.medrxiv.org/content/10.1101/2024.09.24.24314276v1
Reposted by Andrew H. Bass
A powerful framework for differential co-expression analysis of general risk factors https://www.biorxiv.org/content/10.1101/2024.11.29.626006v1
Differential co-expression analysis (DCA) aims to identify genes in a pathway whose shared expressio
www.biorxiv.org
A powerful framework for differential co-expression analysis of general risk factors https://www.biorxiv.org/content/10.1101/2024.11.29.626006v1
Andrew Bass
@ajbass.bsky.social
· Dec 4
GitHub - ajbass/kdca: Kernel-based Differential Co-expression Analysis
Kernel-based Differential Co-expression Analysis. Contribute to ajbass/kdca development by creating an account on GitHub.
github.com
We have software you can use on GitHub: github.com/ajbass/kdca. Work with @epsteinstatgen.bsky.social and @davecutler.bsky.social.
Andrew Bass
@ajbass.bsky.social
· Dec 4
A powerful framework for differential co-expression analysis of general risk factors https://www.biorxiv.org/content/10.1101/2024.11.29.626006v1
A powerful framework for differential co-expression analysis of general risk factors https://www.biorxiv.org/content/10.1101/2024.11.29.626006v1
Differential co-expression analysis (DCA) aims to identify genes in a pathway whose shared expressio
www.biorxiv.org
Differential co-expression arises from shared unmodeled biological variation involving an observed risk factor and an unobserved (or latent) factor. We developed a method to detect such variation in a pathway for general gene expression studies!
Andrew Bass
@ajbass.bsky.social
· Sep 28
Exploiting pleiotropy to enhance variant discovery with functional false discovery rates https://www.medrxiv.org/content/10.1101/2024.09.24.24314276v1
Exploiting pleiotropy to enhance variant discovery with functional false discovery rates https://www.medrxiv.org/content/10.1101/2024.09.24.24314276v1
The cost of acquiring participants for genome-wide association studies (GWAS) can limit sample sizes
www.medrxiv.org
New work with @chr1sw.bsky.social on increasing GWAS power by leveraging summary statistics of related traits! Package available at github.com/ajbass/sffdr.
Reposted by Andrew H. Bass
Identifying latent genetic interactions in genome-wide association studies using multiple traits - Genome Medicine
The "missing" heritability of complex traits may be partly explained by genetic variants interacting with other genes or environments that are difficult to specify, observe, and detect. We propose a n...
genomemedicine.biomedcentral.com
New publication from @epsteinstatgen.bsky.social's crew describing LIT; a kernel method to map genetic variants with interaction effects on multiple phenotypes in biobanks - in Genome Medicine genomemedicine.biomedcentral.com/articles/10....
Andrew Bass
@ajbass.bsky.social
· Sep 13
Identifying latent genetic interactions in genome-wide association studies using multiple traits
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
A preprint of my first post-doc paper w/ Shijia Bian, Aliza Wingo, Thomas Wingo, David Cutler and @epsteinstatgen.bsky.social is out!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...