We first examined the possibility of complex formation between the XD and MMO for solar-hybrid biocatalyst development to achieve methane conversion. To this end, we used MMOH as a model enzyme and EY as a model light-harvesting dye because MMOH...

Bioproduction from one-carbon compounds, such as formate, is an attractive prospect due to reduced energy requirements and the possibility for using CO2 as a sustainable feedstock. Formate-fixing path...

 A self-sufficient heterogeneous biocatalyst (ssHB) composed of two NADH-dependent dehydrogenases co-immobilized with NADH on porous supports enables the redox disproportionation of HMF, yielding bot...

This paper presents an advanced multi-doped molybdenum oxide nanodots with tunable ammonium and proton doping, exhibiting strong ROS generation. The material demonstrates ultrafast and complete dye degradation and unique selective toxicity toward cancer cells, highlighting its promising potential for cancer therapy applications. Abstract The reactive oxygen species (ROS) serve a significant role in cancer therapy due to their oxidative capabilities to modulate cellular functions from homeostasis to apoptosis. While conventional noble metal nanoparticles exhibit superior biocatalytic efficacy in ROS induction, their indistinctive toxicity toward cells and organisms limit their potential for targeted cancer therapy. Here, ultrathin biocompatiable molybdenum oxides (MoO x ) nanodots are explored that simultaneously incorporate hydrogen (H + ) and ammonia (NH 4 + ) dopants, subsequently their electronic band structures can be modulated by both the relative contents of H + and NH 4 + dopants for efficient generation of ROS. An ultrafast and repeatable dye degredation capability in the absence of light is find in MoO x doped with low H + and high NH 4 + , in which hydroxyl radicals (·OH) is identified as the agent stimulating this ROS-driven process through scavenger analysis. More importantly, the selective biocatalytic potential of such a multi-doped MoO x is demonstrated by the comprehensive assay analysis, revealing a three-fold greater cytotoxicity toward HeLa cancer cells within 24 h compared with those of HEK293T healthy control. The finding shines a light on the targeted cancer therapies that spare healthy cells, showing the potential of multi-doped metal oxide as a biocompatiable alternatives to noble metals in selective cytotoxicity against tumor cells.

A pharmaceutical scientist at the National University of Singapore (NUS) has developed a method that can measure the kinetic efficiency of an enzyme against more than 200,000 potential peptide substrates in a single experiment.

Published in Bioelectrochemistry (Amsterdam, Netherlands)

Brandon BioCatalyst names Peter Beattie as new chairman to champion biotech startups

A dual-functional catalyst that unites peptide catalysis and biocatalysis within a single protein scaffold at two distinct active sites offers a promising strategy for cascade catalysis. This hybrid ...

Doctoral students have described a new selective biocatalyst in an interdisciplinary and inter-university collaboration.

Abstract Cytochrome P450 enzymes (P450s) have gained significant attention due to their remarkable ability to oxidise unactivated C-H bonds with high regio- and stereoselectivity. Their industrial uti...

Favelines, tricyclic benzylcycloheptene diterpenes predominantly found in Cnidoscolus quercifolius, have demonstrated significant cytotoxic activity a…

In the absence of air, microorganisms produce hydrogen using an enzyme called [FeFe]-hydrogenase, one of the most efficient hydrogen-producing biocatalysts known and a promising tool for green…

### 1. 연구 배경 최근 기후 변화 대응과 지속 가능한 에너지 확보의 중요성이 강조되면서, 바이오 연료가 지속 가능한 에너지원으로 주목받고 있습니다. 특히, 바이오디젤은 화석 연료를 대체할 수 있는 잠재력을 가진 유망한 대안입니다. 바이오디젤 생산 기술은 다양한 연구 분야와의 융합을 통해 지속적으로 발전해 왔으며, 특히 생물 촉매(biocatalyst)를 활용한 생산 방식은 기존 화학 촉매 방식에 비해 친환경적이고 에너지 효율적인 측면에서 강점을 보입니다.