The underpinning of the global financial system by the US dollar creates a critical reliance that extends to the UK economy. This post examines this dependency, including global trade and domestic…

Whilst much of the focus has been on the current UK fiscal rules, a more fundamental question is around the sustainability of UK public debt.

In this Review, Luri-Rey et al. present evidence for the crucial role of conventional type 1 dendritic cells in cross-presenting antigens from other cells via the major histocompatibility complex class I antigen-presenting machinery, which in turn is necessary to prime CD8+ T cells, which then mount efficient immune responses against cancer. The authors also discuss how we can exploit these processes in cancer immunotherapy by increasing the number and/or maturation or activation status of this specialist subtype of antigen-presenting cell.