In 216 ligand-bound structures of human FABP isoforms, many at better than 1.2 Å resolution, an estimated 15% of the ligands had a different chemical composition to that expected #StructureBasedDrugDesign #FattyAcidBindingProteins #LigandBinding doi.org/10.1107/S205...
August 26, 2025 at 1:26 PM
In 216 ligand-bound structures of human FABP isoforms, many at better than 1.2 Å resolution, an estimated 15% of the ligands had a different chemical composition to that expected #StructureBasedDrugDesign #FattyAcidBindingProteins #LigandBinding doi.org/10.1107/S205...
Andreas Ehler et al.: A high-resolution data set of fatty acid-binding protein structures. III. Unexpectedly high occurrence of wrong ligands #StructureBasedDrugDesign #FattyAcidBindingProteins #LigandBinding doi.org/10.1107/S205... #IUCr
A high-resolution data set of fatty acid-binding protein structures. III. Unexpectedly high occurrence of wrong ligands
Very high-resolution fatty acid-binding protein structures identified a substantial number of ligands that differ strongly from their expected structure. If different ligand chemistry is a potentially...
doi.org
July 29, 2025 at 11:27 AM
Andreas Ehler et al.: A high-resolution data set of fatty acid-binding protein structures. III. Unexpectedly high occurrence of wrong ligands #StructureBasedDrugDesign #FattyAcidBindingProteins #LigandBinding doi.org/10.1107/S205... #IUCr