#RobWust
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stevefifield.bsky.social
I’m just sharing what I read today. Can’t vouch for the quality, but it seemed to be getting some attention. I am of course interested in observations from those who know more than I do. I merely suffer:

x.com/robwust/stat...
x.com
January 5, 2024 at 8:21 PM
albadocherty.bsky.social
From NYT clown Zeynep's failed PLRC fundraising ploy:

RobWust said his work would have come “to an almost complete stop without the PatientLed funding” because traditional funding sources are so agonizingly slow.

Or, maybe no one ethical would fund your antiscience garbage.
April 14, 2025 at 8:20 PM
loopert.bsky.social
#robwust over #pem , dat veroorzaakt zou kunnen zijn door mitochondriën in spiervezels, afstand genomen van de CGT aanpak.

Maar..... Er is nog steeds geen uitspraak over BPS. Dit wordt niet beantwoord door #q-uestion nocvh door #qsupport
December 5, 2024 at 11:22 PM
valebodi.bsky.social
🧵 from the other place that is getting thousands of views and hundreds of likes and reposts on Dr. Brent Appelman’s PhD Thesis and the research he has been doing w/Prof. @RobWüst in Amsterdam on the phatomechanisms of #PEM in LC & ME/CFS threadreaderapp.com/thread/18785... #LongCOVID #MECFS
Thread by @ValeBodi on Thread Reader App
@ValeBodi: “Patients have to recover for days from, for example, emptying the dishwasher. You can imagine what a disabling disease it is, what an enormous impact it has on your life." “We caused PEM b...
threadreaderapp.com
January 14, 2025 at 10:14 PM
bassjobsen.mastodon.nl.ap.brid.gy
#peenee2 on X wrote:

New preprint #robwust + team

"our observations suggest intrinsic skeletal muscle abnormalities contribute to limited exercise capacity, including reduced capillary supply relative to muscle fiber size and mitochondrial impairments." […]
Original post on mastodon.nl
mastodon.nl
May 6, 2025 at 9:07 PM
drrenemd.bsky.social
x.com/RobWust/stat...
x.com
x.com
December 19, 2024 at 6:04 AM
frogsandstars.bsky.social
'The patient might look completely fine and then experience severe symptoms the day after.' - Dr. Rob Wüst, @RobWust, Assistant-Professor Muscle Metabolism at Vrije University Amsterdam, Netherlands #UniteToFight2024 #longcovid
May 15, 2024 at 9:18 AM
barboxtel.bsky.social
In een baanbrekend onderzoek van
@RobWust
(VU) en internationale collega’s is aangetoond dat skeletspieren van mensen met long covid en ME afwijkingen vertonen die niet alleen door inactiviteit verklaard kunnen worden. Dit onderzoek biedt belangrijke inzichten
www.medrxiv.org/content/10.1...
Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest
Patients with long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suffer from a reduced exercise capacity, skeletal muscle abnormalities and post-exertional malaise (PEM), where...
www.medrxiv.org
May 8, 2025 at 2:15 PM
jimfaas.bsky.social
#LongCovid 🦠 ‘EXERCISE IS NOT MEDICINE IN LONGCOVID’

voor wie het gemist heeft

✅belangrijk artikel👇van @RobWust @KasperJanssen ea

✅ ‘Post-exertionele malaise is de verergering van klachten na inspanning, waardoor sommige vormen van revalidatie en fysiotherapie averechts werken’
October 7, 2023 at 4:49 PM
thechiller.bsky.social
Re raising your heart rate/exercise, after even a ridiculously mild covid infection. Here's all you need to know. 👇

The best thing you can do is not catch it, #MaskUp with an FFP2 or 3 around people. But if you do get it, please don't end up like me. Heed this advice re your recovery.
Tweet from Australian respiratory physician, David Joffe: "Dani, my rule is nothing for 6-8 weeks. The inflammation continues long after the fever and cough. Keep your HR (heart rate) as low as possible. One of the few things we know can limit the risk of Long Covid. Same rule as any pneumonia or major illness." This is the two quoted in the previous image. It's by Danielle Beckman, a neuroscientist working in biophysics and biological chemistry: "Some people have asked in the comments why you should not exercise for at least 6-8 weeks after getting covid. Researchers like @robwust have recently shown that covid infection can induce changes in skeletal muscle structure and function, which can be worsened after exercise." Still from a video retweeted by Danielle Beckman with the comment "she is pretty awesome". Video text as follows: "I've made a video about this before, but it is so important because people still don't realise that you should not exercise for at least 6 weeks after a covid infection. I don't care if you feel barely symptomatic with a sniffle, you are setting yourself up for chronic illness and disability. Google 'myalgic encephalomyelitis' - you do not want this. Exercising through this shit is a great way to end up with that disability. There is no funding. No research. You are screwed and you will probably be disabled for the rest of your life. Please listen to people who are reading all of the literature. Do not exercise until you are past that 6 weeks. And even then, as soon as your body is telling you stop or that you are overexerting, listen to your body. Don't play the toxic-ass Nike 'Just Do It' shit we grew up with. Please listen to disabled people."
May 28, 2024 at 7:28 AM
pflegeherz.bsky.social
5/1 kommen sie nicht mehr überall hin. Hinzu kommt, dass sie den Sauerstoff stärker an sich binden und nicht mehr oder nur in geringem Maße an die Muskeln abgeben. Die Aussagen passen zu einer durch @RobWust initiierten Studie, die im Ergebnis u.a. auch von Endothelschäden
December 20, 2024 at 10:05 AM
bassjobsen.mastodon.nl.ap.brid.gy
#robwust on X wrote:

THREAD: Skeletal Muscle Alterations in Long COVID and ME/CFS
1/ 💡 Study Overview
We studied whether skeletal muscle changes in Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) patients are due to inactivity or distinct pathological processes.

🧵 […]
Original post on mastodon.nl
mastodon.nl
May 6, 2025 at 9:12 PM
marlieskdg.bsky.social
Het team van Rob Wust krijgt de beschikking over apparatuur om ook in NL onderzoek naar microclots te kunnen gaan doen!

#LongCovid #ME
#NieuwsVanX
Resia Pretorius Twittert: 'A fantastic week in The Netherlands comes to an end with collaborators @DrDenDunnen and @RobWust. Imaging flow cytometer method established for research here on microclots. Transmission electron microscopy dabbled in'.
April 13, 2025 at 11:54 AM
frogsandstars.bsky.social
'We need to listen to patients because they have the most experience with the pathophysiology.' - Dr. Rob Wüst, @RobWust, Assistant-Professor Muscle Metabolism at Vrije University Amsterdam, Netherlands #UniteToFight2024 #longcovid
May 15, 2024 at 9:13 AM
cbammermd.bsky.social
Two take-home messages fom the #ME/CFS #Fachtagung2024 in Fulda:

1️⃣ @RobWust says, there‘s fiber type plasticity in sceletal muscle. In pts. with LC or ME, there are higher quantities of type 2 fibers, which are less oxidative and more glycolytic.
1/6
September 14, 2024 at 9:57 AM
drinfosec.bsky.social
🎯🧵 shared by @anilvanderzee.bsky.social on one of the talks (on collagen IV in folks with ME & LC) at the recent int/l #MECFS conf 2025 in Germany
threadreaderapp.com/thread/19343...

featuring work by @robwust and @drdendunnen.bsky.social
Thread by @AnilvanderZee on Thread Reader App
@AnilvanderZee: 1) Fascinating talks by the Dutch researchers Anouk Slaghekke, @RobWust and @DrDenDunnen at the International #MECFS Conference 2025 by the @MECFSResearch in Germany. I just extracted ...
threadreaderapp.com
June 15, 2025 at 9:30 PM
670rv.bsky.social
It is time for this nation and world to share information.
We need:
@zalaly.bsky.social @putrinolab.bsky.social @virusesimmunity.bsky.social
@michaelpelusomd.bsky.social
@erturklab.bsky.social
@
Rob Wüst
@RobWust (on X)
to gather and highlight.
February 11, 2025 at 10:46 PM
itsbabs.bsky.social
the best way to prevent longcovid is not to be infected with SARS2, but if you do get covid (as most people have more than once), the best things you can do to prevent longcovid are: get paxlovid / antiviral(s), and REST.
Preventive Medicine Reports Association of COVID vaccinations & treatments with long COVID beyond 6 months: a case-control study on the adult population in a large integrated healthcare system in the United States from 2020 to 2023 Curtis Liu, Celina Liu, Rui Yan, Davida Becker, Jia Xiao Shi, Jeffrey Slezak, Diane Jerng* ABSTRACT Objective: Long coronavirus disease (Long COVID) is a chronic condition causing significant long-term disability and economic burden. This study aims to measure the association between COVID vaccinations and treatment at the time of acute infection with Long COVID outcomes beyond six months post-infection, controlling for demographic and medical variables. Methods: This retrospective case-control study used electronic medical records from Kaiser Permanente Southern California to evaluate Long COVID outcomes from January 2022 to June 2023 with vaccination doses and nirmatrelvir/ritonavir, and from October 2020 to June 2023 with remdesivir and other treatments. Statistical analysis used univariate chi-square and Kruskal-Wallis tests and conditional logistic regression. Results: Our study had 840 (January 2022 analysis) and 2632 (October 2020 analysis) Long COVID patients diagnosed by International Classification of Diseases-10 code at least 6 months after acute COVID infection with 1:5 matched controls by age, sex, race/ethnicity, Body Mass Index, and date of acute COVID infection. Long COVID outcome was inversely associated with the number of COVID vaccination doses (…) treatment with no interaction between three vaccinations with nirmatrelvir/ritonavir and four vaccinations with remdesivir treatment. Conclusion: These findings may influence existing clinical practices for vaccination & antiviral treatment tweet: David Joffe PhD, FRACP @DavidJoffe64 “Dani, My rule is nothing for 6-8 weeks. The inflammation continues long after the fever and cough. Keep your HR as low as possible. One of the few things we know can limit the risk of Long C-19. Same rule as any pneumonia or major illness.” quote tweet: Danielle Beckman @DaniBeckman “Some people asked in the comments why you should not exercise for at least 6-8 weeks after getting #COVID19. Researchers like @RobWust have recently shown that SARS-CoV-2 infection can induce changes in skeletal muscle structure and function, which can be worsened after...” nature communications Article https://doi.org/10.1038/s41467-023-44432-3 Muscle abnormalities worsen after post-exertional malaise in long COVID Received: 21 March 2023 Accepted: 13 December 2023 Published online: 04 January 2024 Brent Appelman, Braeden T. Charlton, Richie P. Goulding, Tom J. Kerkhoff, Ellen A. Breedveld, Wendy Noort, Carla Offringa, Frank W. Bloemers, Michel van Weeghel, Bauke V. Schomakers, Pedro Coelho, Jelle J. Posthuma, Eleonora Aronic, W. Joost Wiersing, Michèle van Vugt & Rob C. I. Wüst A subgroup of patients infected with SARS-Cov-2 remain symptomatic over three months after infection. A distinctive symptom of patients with long COVID is post-exertional malaise, which is associated with a worsening of atigue- and pain-related symptoms after acute mental or physical exercis ut its underlying pathophysiology is unclear. With this longitudinal case control study (NCT05225688), we provide new insights into the pathophy-siology of post-exertional malaise in patients with long COVID. We show that skeletal muscle structure is associated with a lower exercise capacity in patients, and local and systemic metabolic disturbances, severe exercise-induced myopathy and tissue infiltration of amyloid-containing deposits in skeletal muscles of patients with long COVID worsen after induction of post-exertional malaise. This study highlights novel pathways that help to under-From the Coho and dege posterios al malaise in patients suffering
August 18, 2025 at 9:36 PM
ralfwittenbrink.bsky.social
wiesen auf:

➡️ Mitochondriale Dysfunktion
➡️ Veränderte Muskelfaserzusammensetzung
➡️ Veränderte Kapillarversorgung

Diese Veränderungen konnten bei gesunden Personen, die strenger Bettruhe unterworfen waren, nicht repliziert werden!

Danke 🙏🏼 Rob Wüst
Screenshot Rob Wüst @RobWust THREAD: Skeletal Muscle Alterations in Long COVID and ME/CFS 1/ Study Overview We studied whether skeletal muscle changes in Long COVID and Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) patients are due to inactivity or distinct pathological processes. 21:50 • 06.05.25 • 6,6K Mal angezeigt Both Long COVID and ME/CFS patients exhibited: Mitochondrial dysfunction Altered muscle fiber composition Altered capillary supply These changes were not replicated in healthy individuals subjected to strict bed rest (done with ESA and NASA). Methodology The study involved skeletal muscle biopsies and assessments of whole body exercise responses, comparing: -Long COVID patients -ME/CFS patients -Healthy controls before and after bed rest Findings suggest unique muscle pathology in Long COVID and ME/CFS. Conclusions Understanding these distinct muscle changes is crucial for developing effective treatments for Long COVID and ME/CFS patients, moving beyond the inaccurate recommendations to simply increase physical activity.
May 6, 2025 at 10:05 PM
postviraltrials.bsky.social
Rob Wüst will be doing a phase 2 trial of Sonlicromanol for post-Covid PEM, funded by ZonMw vu.nl/nl/nieuws/20... x.com/robwust/stat...
November 6, 2024 at 8:47 PM
crearose.bsky.social
Ik qoute @anilvanderzee.bsky.social even omdat hij niet hier actief is.
"Geweldige reactie van @RobWust et al. die de reactie van Ranque et al. pijnlijk dwaas doet lijken. Aan de ene kant triest dat we deze onzinnige beweringen nog steeds moeten weerleggen,
www.nature.com/articles/s41...
Reply: Muscle abnormalities in Long COVID - Nature Communications
Nature Communications - Reply: Muscle abnormalities in Long COVID
www.nature.com
February 17, 2025 at 8:59 AM
bendyhedsandco.bsky.social
Here's copy if not on 🐦
sorry unable to copy more.
@RobWust are you including hypermobility in your research? eg have you seen Dr Alan Hakim & co studies with long covid & Hypermobility (higher than expected).
Also @CortDoesScience @NorrisLab #hEDS research inc MCAS & poss effect on hypermobility.
October 3, 2024 at 1:54 PM
powerfromspace1.bsky.social
@RubWust After a long wait, our longitudinal #COVID #LongCovid study is finally published in @NatureComms:

www.nature.com/articles/s41...

We find a skeletal muscle alterations in patients with #longcovid, which worsen with exercise. 1/n

x.com/robwust/stat...
Muscle abnormalities worsen after post-exertional malaise in long COVID - Nature Communications
In this longitudinal, case-controlled, cohort design study, authors show that post-exertional malaise is associated with severe exercise-induced myopathy, local and systemic metabolic disturbances and...
www.nature.com
January 4, 2024 at 8:26 PM
jokb.bsky.social
Laatste onderzoek wat ik vond.
Jammer dat @RobWüst niet op Bluesky is

www.medrxiv.org/content/10.1...
Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest
Patients with long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suffer from a reduced exercise capacity, skeletal muscle abnormalities and post-exertional malaise (PEM), where...
www.medrxiv.org
May 17, 2025 at 12:12 PM
itsbabs.bsky.social
the acute symptoms may be awful, or they may be so mild you almost didn’t think you were sick. either way, you’re at risk for developing longcovid, or post-acute symptoms lasting at least 3mo, if not longer, sometimes indefinitely.

once you’re infected, REST. see 🧵⬇️ for more info on longcovid.
TIME HEALTH • COVID-19 Why You Should Rest—a Lot—If You Have COVID-19 6 MINUTE READ TIME BY JAMIE DUCHARME X SEPTEMBER 23, 2022 9:15 AM EDT David Joffe PhD, FRACP 1: @DavidJoffe64 “Dani, My rule is nothing for 6-8 weeks. The inflammation continues long after the fever and cough. Keep your HR as low as possible. One of the few things we know can limit the risk of Long C-19. Same rule as any pneumonia or major illness.” quote tweet: Danielle Beckman @DaniBeckman • 20h “Some people asked in the comments why you should not exercise for at least 6-8 weeks after getting #COVID19. Researchers like @RobWust have recently shown that SARS-CoV-2 infection can induce changes in skeletal muscle structure and function, which can be worsened after... x.com/DaniBeckman/“ [ image of paper: Fig. 3: Metabolic and mitochondrial dysfunction in long COVID patients worsens with post-exertional malaise. From: Muscle abnormalities worsenafter.post-exertional malaise.in.long.COMID ]
August 2, 2025 at 8:39 PM