Our new paper in PLOS CompBio introduces the R-loop grammar—a formal-language model that predicts R-loop formation across different DNA topologies from SMRF-seq data alone. It captures topology outperforming other methods
journals.plos.org/ploscompbiol...
#ComputationalBiology #Rloops #DNAtopology

📢Researchers at IIMCB & IBB PAS developed a new tool to detect RNA/DNA double helices. These are key components of R-loops – structures crucial for genome stability. Using an engineered bacterial RNase H domain, this method works both in vitro and in cells.
Paper: tinyurl.com/msbuznff
#RLoops

Explore chromosomal R-loops with Lóránt Szekvolgyi—his talk starts soon! 🧬
Dive deeper with his Perspective article: tinyurl.com/2kjphmva
😊 #Genomics #Rloops #FEBS2025

What role do #Rloops play in viral #infection? 🧬🦠 Karányi et al. explore links to viral genes, #transposons & R-loop–associated responses – read their Perspective:
#virology #DNA #RNA

➡️ doi.org/10.1002/1873-3468.70086

🆕 Review to start your week!

Possible role of human ribonuclease dicer in the regulation of R loops

🔓 buff.ly/9Am67ML

#Rloops #Ribonuclease #CancerBiology

#DFG approves new #ResearchTrainingGroup on the #biology of #Rloops at #UniMainz, @imbmainz, and @UnimedizinMainz: "R-loop Regulation in Robustness and Resilience" (4R) dedicates itself to highly topical field of research...

#DFG genehmigt neues #Graduiertenkolleg auf dem Gebiet der #Chromosomen-#Biologie zur Erforschung von #RLoops: "R-loop Regulation in Robustness and Resilience" (4R) widmet sich hochaktuellem Forschungsfeld @imbmainz, @UnimedizinMainz und @uni_mainz...

Researchers find link between excessive R-loop levels and #DNA damage to be a potential cause of disease https://www.uni-mainz.de/presse/aktuell/15114_ENG_HTML.php #biology #LifeSciences #proteomics #cancer #leukemia #GenomicInstability #DDX41 #RLoops #research @imbmainz...

Zusammenhang zwischen überschüssigen #RLoops und #DNA-Schäden mit möglichen Krankheitsfolgen festgestellt https://www.uni-mainz.de/presse/aktuell/15114_DEU_HTML.php @imbmainz