New study by Caio Sena & coauthors reveals tamarind seed trypsin inhibitor can also inhibit α-amylase, a key enzyme in carb digestion

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doi.org/10.1371/jour...

#DiabetesResearch #Tamarind #GlycemicControl

Arkajit De and team used AlphaFold2 to model a key Marburg virus protein and identified four potential inhibitors. Lab tests are needed to confirm their effectiveness.

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Article lnkd.in/dj_3tzkq

Noelia Moaresand co-authors present the CARtein system, a modular CAR platform using intein-mediated splicing to enable dual targeting of BCMA and SLAMF7 in multiple myeloma

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Full article: doi.org/10.3389/fimm...

Using a computational approach, Caio Sena and co-authors combined molecular dynamics and DFT to investigate how different antagonists interact with the orexin receptor OXR1.

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Full article: doi.org/10.3390/mole...

New tools are unveiling the complex folds and functions of RNA, once seen as merely a messenger between DNA and proteins.

Illustration made by Tales Rocha using #ProtienImager 3dproteinimaging.com/protein-imager

doi.org/10.1038/s415...

Synthetic catalysts like nanozymes & artificial enzymes are revolutionizing medicine. But are they safe? A new review urges adoption of Safe & Sustainable-by-Design (SSbD) to guide their future in therapy.

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doi.org/10.1002/cctc...

New study by Francisco J. Enguita et al. reveals cross-kingdom enzymatic strategies for deoxynivalenol (DON) detoxification. 🌾🔬

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article: doi.org/10.3390/micr...

#Mycotoxins #FoodSafety #Microbiology

Machine learning is transforming how we predict de novo protein–protein interactions (PPIs) — interactions never before seen in nature.

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doi.org/10.1016/j.ti...

#AI #MachineLearning #Biotech #DrugDiscovery #AlphaFold

In this review Enguita and coauthor analyze key RNA structural motifs, experimental & computational methods, and the need for deeper studies to uncover RNA structure-function relationships

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www.mdpi.com/2311-553X/11...

A recent study has identified five novel capsaicinoids from 40 chili pepper varieties, deepening our understanding of how these compounds interact with the TRPV1 receptor.

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doi.org/10.1016/j.ej...