#Progerin
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biorxiv-pathology.bsky.social
Mutation-Agnostic Base Editing of the Progerin Farnesylation Site Rescues Hutchinson-Gilford Progeria Syndrome Phenotypes in Neuromuscular Organoids https://www.biorxiv.org/content/10.1101/2025.10.16.682736v1
October 16, 2025 at 6:00 PM
biorxivpreprint.bsky.social
Mutation-Agnostic Base Editing of the Progerin Farnesylation Site Rescues Hutchinson-Gilford Progeria Syndrome Phenotypes in Neuromuscular Organoids https://www.biorxiv.org/content/10.1101/2025.10.16.682736v1
October 16, 2025 at 6:00 PM
annaekoch.bsky.social
I feel very honoured that my poster "Premature progerin-driven aging promotes G-quadruplex DNA and interlinked genome instability" was selected for the Best Poster Award at the PhD days of the "Graduate School for Biological Sciences"! Thank you to the organisers for this amazing event.
September 30, 2025 at 10:35 AM
helixbrief.bsky.social
These findings suggest that progerin can suppress the epithelial-mesenchymal transition, a crucial process in tumor metastasis.
September 28, 2025 at 1:24 PM
helixbrief.bsky.social
Mechanistically, progerin altered the organization of the actin cytoskeleton and reduced the expression of mesenchymal markers, while increasing the epithelial marker E-cadherin.
September 28, 2025 at 1:24 PM
helixbrief.bsky.social
Progerin overexpression was found to significantly inhibit TNBC cell migration, invasion, and adhesion, without affecting cell senescence or proliferation.
September 28, 2025 at 1:24 PM
helixbrief.bsky.social
This study investigated the effects of progerin, a mutant form of the lamin A protein, on triple-negative breast cancer (TNBC) cells.
September 28, 2025 at 1:24 PM
helixbrief.bsky.social
Progerin, a mutant protein, surprisingly halts the spread of aggressive triple-negative breast cancer by restructuring the cell's internal skeleton and suppressing the epithelial-mesenchy...

🧵 Thread below

Full analysis: https://helixbrief.com/article/8f0195b7-fec4-4f8d-84eb-b30e27982d3c
September 28, 2025 at 1:24 PM
biorxivpreprint.bsky.social
Transcriptional profiling of Hutchinson-Gilford Progeria patients identifies primary target pathways of progerin https://www.biorxiv.org/content/10.1101/2025.09.18.677125v1
September 20, 2025 at 1:30 PM
biorxiv-cellbio.bsky.social
Transcriptional profiling of Hutchinson-Gilford Progeria patients identifies primary target pathways of progerin https://www.biorxiv.org/content/10.1101/2025.09.18.677125v1
September 20, 2025 at 1:30 PM
medrxivpreprint.bsky.social
Topical application of a skin serum with Progerin inhibitor helps alleviate human skin aging https://www.medrxiv.org/content/10.1101/2025.09.10.25335131v1
September 12, 2025 at 9:56 PM
artstradamagazine.bsky.social
Progerin (UniProt# P02545-6) is a truncated version of the lamin A protein involved in the pathology of Hutchinson–Gilford progeria syndrome
en.wikipedia.org/wiki/Progerin
August 27, 2025 at 9:22 AM
sciences.skyfleet.blue
Attenuated Nuclear Tension Regulates Progerin‐Induced Mechanosensitive Nuclear Wrinkling and Chromatin Remodeling (Adv. Sci. 31/2025)
Attenuated Nuclear Tension Regulates Progerin‐Induced Mechanosensitive Nuclear Wrinkling and Chromatin Remodeling (Adv. Sci. 31/2025)
Nuclear Tension In article number 2502375 , Dong-Hwee Kim, and co-workers present a mechanobiological mechanism of progerin-induced wrinkling of nuclear surface. They demonstrate a new biophysical aging process that the abnormal nuclear shape leads to the regulation of aging-dependent changes of gene profiles.
advanced.onlinelibrary.wiley.com
August 24, 2025 at 7:46 PM
haoyin.bsky.social
#HGPS #Aortopathy

The age-related accumulation of immature Lamin A, #Progerin or Farnesyl-Prelamin A, ⏫Stretch-induced loss of aortic #SmoothMuscleCell

Comparative analysis among
1⃣LmnaG609G/+
2⃣Zmpste24-/-
3⃣SM22a-Cre::Zmpste f/f::LmnaPLAO/PLAO🐭

#CellDeathDis 2025
www.nature.com/articles/s41...
July 28, 2025 at 7:04 PM
agingbiology.bsky.social
Recurrent somatic mutation and progerin expression in early vascular aging of chronic kidney disease
www.nature.com/articles/s43...
Recurrent somatic mutation and progerin expression in early vascular aging of chronic kidney disease - Nature Aging
Progerin, a truncated version of lamin A, causes Hutchinson–Gilford progeria syndrome characterized by premature aging and cardiovascular complications. Here the authors show that the most common prog...
www.nature.com
June 19, 2025 at 11:04 PM
haoyin.bsky.social
Lack of adverse vascular phenotypes in mice with postnatal induction of #EndothelialCell #Progerin
Lmna LCS/LCS::Cdh5-CreERT2
Tamoxifen 1.5-mo
Monitored till 22-mo

Normal lifespan
No #Progeria
No Cardiac Fibrosis
No aggravated Atherosclerosis

#AgingCell 2024
onlinelibrary.wiley.com/doi/10.1111/...
November 10, 2024 at 2:07 PM
biorxivpreprint.bsky.social
The Accumulation of Progerin Underlies the Loss of Aortic Smooth Muscle Cells in Hutchinson-Gilford Progeria Syndrome https://www.biorxiv.org/content/10.1101/2024.10.29.620896v1
The Accumulation of Progerin Underlies the Loss of Aortic Smooth Muscle Cells in Hutchinson-Gilford Progeria Syndrome https://www.biorxiv.org/content/10.1101/2024.10.29.620896v1
Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disorder characterized by multiple aging-
www.biorxiv.org
November 4, 2024 at 2:30 AM
biorxiv-cellbio.bsky.social
The Accumulation of Progerin Underlies the Loss of Aortic Smooth Muscle Cells in Hutchinson-Gilford Progeria Syndrome https://www.biorxiv.org/content/10.1101/2024.10.29.620896v1
The Accumulation of Progerin Underlies the Loss of Aortic Smooth Muscle Cells in Hutchinson-Gilford Progeria Syndrome https://www.biorxiv.org/content/10.1101/2024.10.29.620896v1
Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disorder characterized by multiple aging-
www.biorxiv.org
November 4, 2024 at 2:30 AM
haoyin.bsky.social
#HutchinsonGilfordProgeriaSyndrome

HGPS hiPSC #EndothelialCell Secretome screening->
#Angiopoietin2 autocrine (⏫#Angiogenesis #NitricOxide) & paracrine (⏬ #SmoothMuscleCell death #Senescence)

#BaseEditing Progerin⏫Angpt2 & HGPS EC behaviors
#Aging_Cell 2024
onlinelibrary.wiley.com/doi/10.1111/...
October 19, 2024 at 7:15 PM
haoyin.bsky.social
#HutchinsonGilfordProgeriaSyndrome

#Senescence/#Aging features of Isogenic HGPS #hiPSC-#EndothelialCell vs #SmoothMuscleCell

#Progerin <
Nuclear deformation <
#Senescence >
#DNADamage ~
#TelomereLength <
#Shelterin
#SASP
#Heterochromatin loss ~

#EHJOpen 2022
academic.oup.com/ehjopen/arti...
October 10, 2024 at 7:26 PM
biorxiv-molbio.bsky.social
Progerin Can Induce DNA Damage in the Absence of Global Changes in Replication or Cell Proliferation https://www.biorxiv.org/content/10.1101/2024.07.02.601729v1
Progerin Can Induce DNA Damage in the Absence of Global Changes in Replication or Cell Proliferation https://www.biorxiv.org/content/10.1101/2024.07.02.601729v1
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic condition characterized by features of
www.biorxiv.org
July 3, 2024 at 3:18 AM
biorxivpreprint.bsky.social
Progerin Can Induce DNA Damage in the Absence of Global Changes in Replication or Cell Proliferation https://www.biorxiv.org/content/10.1101/2024.07.02.601729v1
Progerin Can Induce DNA Damage in the Absence of Global Changes in Replication or Cell Proliferation https://www.biorxiv.org/content/10.1101/2024.07.02.601729v1
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic condition characterized by features of
www.biorxiv.org
July 3, 2024 at 3:18 AM
haoyin.bsky.social
Removing progerin (pathogenic Lamin A variant in #HutchinsonGilfordProgeriaSyndrome) from #SmoothMuscleCell (or cardiomyocyte as well?), but not #EndothelialCell, ⏬progeroid HGPSrev🐭#Atherosclerosis

Aortic medial collagen is almost depleted in HGPSrev🐭!

#PNAS 2024
www.pnas.org/doi/10.1073/...
April 24, 2024 at 11:17 AM