(Poly)phenols are plant-derived bioactive molecules that are associated with several health benefits. Therefore, it is essential to study the factors that affect the bioavailability of these phenolic compounds. Recently, circannual rhythms have been identified as one of the factors that may affect the bioavailability of these compounds. Hence, this study evaluates the impact of circannual rhythms on grape seed proanthocyanidins extract (GSPE) bioavailability in healthy and obesogenic contexts. Male Fischer 344 rats, fed standard (ST) or cafeteria (CAF) diets, were housed under different photoperiod conditions (6, 12, or 18 h of light per day) during 9 weeks and an oral dose of GSPE (25 mg/kg) was daily administered for the last 4 weeks. Serum GSPE-derived metabolites were then quantified by HPLC-ESI-MS/MS. A higher bioavailability was observed in rats exposed to a 12 h photoperiod and fed ST diet. However, this pattern was altered in CAF-fed rats, suggesting an attenuated influence of photoperiod under obesogenic conditions. These findings contribute to a better understanding of the complex relationships between diet, photoperiod, and serum metabolites.

The hawthorn health benefits derive from bioactive compounds in its leaves, flowers, and berries—flavonoids, oligomeric proanthocyanidins (OPCs), triterpenoids, vitamins, and minerals support heart and digestive wellness, reduce inflammation and oxidative stress. However, hawthorn does not cure chronic diseases and should not be used as a substitute for professional medical care. 🌿 Nutrients & Phytochemical Properties of Hawthorn Hawthorn is rich in…

Global Proanthocyanidins market size is expected to reach $4.2 billion by 2029 at 10%, proanthocyanidin market surge fueled by rising prevalence of lifestyle-related diseases

In his post, he mentioned the benefits of drinking cranberry juice for gut immunity. The study also states that the A-type structure of cranberry proanthocyanidins seems to be responsible for much of this fruit's efficacy as a natural antimicrobial. The study also states that a limited but growing body of evidence from randomized clinical trials reveals favorable effects of cranberry consumption on measures of cardiometabolic health, including serum lipid profiles, blood pressure, endothelial function, glucoregulation, and a variety of biomarkers of inflammation and oxidative stress. All Images Courtesy: istock ​

Rhodiola rosea has been used as a traditional medicine for a long history. Previous studies on oligomeric proanthocyanidins from Rhodiola rosea (OPCRR…