Defining the Mycobacterium tuberculosis Pangenome and Suggestions for a New Composite Reference Sequence. #MycobacteriumTuberculosis #Pangenome #ReferenceSequence @biorxivpreprint.bsky.social 🧪
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 8, 2025 at 11:49 AM
Defining the Mycobacterium tuberculosis Pangenome and Suggestions for a New Composite Reference Sequence. #MycobacteriumTuberculosis #Pangenome #ReferenceSequence @biorxivpreprint.bsky.social 🧪
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
This study demonstrates the effectiveness of targeted #NextGenerationSequencing of #BronchoalveolarLavage fluid in detecting both #MycobacteriumTuberculosis and #NontuberculousMycobacteria infections, highlighting its promise as a diagnostic tool for future #Clinical use. #medsky
buff.ly/kSTkfV8
buff.ly/kSTkfV8
October 13, 2025 at 5:58 AM
This study demonstrates the effectiveness of targeted #NextGenerationSequencing of #BronchoalveolarLavage fluid in detecting both #MycobacteriumTuberculosis and #NontuberculousMycobacteria infections, highlighting its promise as a diagnostic tool for future #Clinical use. #medsky
buff.ly/kSTkfV8
buff.ly/kSTkfV8
#Medsky🧪 #IDsky #immunosky #episky #publichealth @cellpress.bsky.social
#Mycobacteriumtuberculosis (Mtb) has co-evolved with humans for thousands of years causing variation in virulence, transmissibility, & disease phenotypes.
www.cell.com/cell/fulltex...
#Mycobacteriumtuberculosis (Mtb) has co-evolved with humans for thousands of years causing variation in virulence, transmissibility, & disease phenotypes.
www.cell.com/cell/fulltex...
Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance
Mycobacterium tuberculosis isolates have a complex phylogenetic structure and vary
in clinical phenotypes. Combining high-throughput RNA-seq and global population genomics
reveals gene expression as a...
www.cell.com
October 1, 2025 at 7:31 AM
#Medsky🧪 #IDsky #immunosky #episky #publichealth @cellpress.bsky.social
#Mycobacteriumtuberculosis (Mtb) has co-evolved with humans for thousands of years causing variation in virulence, transmissibility, & disease phenotypes.
www.cell.com/cell/fulltex...
#Mycobacteriumtuberculosis (Mtb) has co-evolved with humans for thousands of years causing variation in virulence, transmissibility, & disease phenotypes.
www.cell.com/cell/fulltex...
Tuberculosis (TB): Causes, Symptoms, Diagnosis, and Treatment Explained
#Tuberculosis #StopTB #TBawareness #InfectiousDiseases #PublicHealth #GlobalHealth #LungHealth #VikaasShandily #MycobacteriumTuberculosis
#Tuberculosis #StopTB #TBawareness #InfectiousDiseases #PublicHealth #GlobalHealth #LungHealth #VikaasShandily #MycobacteriumTuberculosis
September 16, 2025 at 10:30 AM
Tuberculosis (TB): Causes, Symptoms, Diagnosis, and Treatment Explained
#Tuberculosis #StopTB #TBawareness #InfectiousDiseases #PublicHealth #GlobalHealth #LungHealth #VikaasShandily #MycobacteriumTuberculosis
#Tuberculosis #StopTB #TBawareness #InfectiousDiseases #PublicHealth #GlobalHealth #LungHealth #VikaasShandily #MycobacteriumTuberculosis
#simpsons #marge #Löwenstein #agar #Lowenstein-Jensen #Mycobacterium #Mycobacteriumtuberculosis #tb #lab #medsky #medtech #mls #microbiology
September 14, 2025 at 5:00 AM
UShER-TB: Scalable, Comprehensive, Accessible Phylogenomic Analysis of Mycobacterium tuberculosis
Bell, J. M., Comas, I. et al.
Paper
Details
#MycobacteriumTuberculosis #PhylogenomicAnalysis #UsherTBStudy
Bell, J. M., Comas, I. et al.
Paper
Details
#MycobacteriumTuberculosis #PhylogenomicAnalysis #UsherTBStudy
July 26, 2025 at 4:04 PM
UShER-TB: Scalable, Comprehensive, Accessible Phylogenomic Analysis of Mycobacterium tuberculosis
Bell, J. M., Comas, I. et al.
Paper
Details
#MycobacteriumTuberculosis #PhylogenomicAnalysis #UsherTBStudy
Bell, J. M., Comas, I. et al.
Paper
Details
#MycobacteriumTuberculosis #PhylogenomicAnalysis #UsherTBStudy
Read the latest Journal of #Infection for the examination of how latent #TBInfection, evaluated by cell-mediated immune responses to #MycobacteriumTuberculosis antigens, impacts glucose metabolism in US adults 👉 www.journalofinfecti...
July 17, 2025 at 9:44 AM
Read the latest Journal of #Infection for the examination of how latent #TBInfection, evaluated by cell-mediated immune responses to #MycobacteriumTuberculosis antigens, impacts glucose metabolism in US adults 👉 www.journalofinfecti...
Small RNA ASpks2 Promote Mycobacterium tuberculosis Survival in Macrophages via Targeting Polyketide Synthase 2
Bi, l., Chen, Y. et al.
Paper
Details
#ASpks2 #MycobacteriumTuberculosis #MacrophageSurvival
Bi, l., Chen, Y. et al.
Paper
Details
#ASpks2 #MycobacteriumTuberculosis #MacrophageSurvival
June 15, 2025 at 11:37 AM
Small RNA ASpks2 Promote Mycobacterium tuberculosis Survival in Macrophages via Targeting Polyketide Synthase 2
Bi, l., Chen, Y. et al.
Paper
Details
#ASpks2 #MycobacteriumTuberculosis #MacrophageSurvival
Bi, l., Chen, Y. et al.
Paper
Details
#ASpks2 #MycobacteriumTuberculosis #MacrophageSurvival
Structural analysis of M. tuberculosis Rv2173 reveals a canonical class I diterpene synthase fold and supports its annotation as a short-chain product-length synthase #MycobacteriumTuberculosis #IsoprenylDiphosphateSynthase #Rv2173 doi.org/10.1107/S205...
May 8, 2025 at 12:41 PM
Structural analysis of M. tuberculosis Rv2173 reveals a canonical class I diterpene synthase fold and supports its annotation as a short-chain product-length synthase #MycobacteriumTuberculosis #IsoprenylDiphosphateSynthase #Rv2173 doi.org/10.1107/S205...
S-Adenosyl-N-decyl-aminoethyl is identified as a promising potential inhibitor for the SAM-dependent mycolic acid synthase UmaA from Mycobacterium tuberculosis #SAMDependentMycolicAcidSynthase #UmaA #MycobacteriumTuberculosis doi.org/10.1107/S205...
April 10, 2025 at 2:43 PM
S-Adenosyl-N-decyl-aminoethyl is identified as a promising potential inhibitor for the SAM-dependent mycolic acid synthase UmaA from Mycobacterium tuberculosis #SAMDependentMycolicAcidSynthase #UmaA #MycobacteriumTuberculosis doi.org/10.1107/S205...
James A. Titterington et al.: Structures of Mycobacterium tuberculosis isoprenyl diphosphate synthase Rv2173 in substrate-bound forms ##MycobacteriumTuberculosis##IsoprenylDiphosphateSynthase##Rv2173@AucklandUni...##IUCrhttps://journals.iucr.org/paper?S2053230X25002298
Structures of Mycobacterium tuberculosis isoprenyl diphosphate synthase Rv2173 in substrate-bound forms
We report the structure of M. tuberculosis isoprenyl diphosphate synthase Rv2173 in three forms, including two with substrate (isoprenyl diphosphate and dimethylallyl diphosphate) occupying the allylic substrate site in different binding poses, with different numbers of metal ions bound. The homodimeric structures possess a canonical all-α-helical trans-isoprenyl diphosphate synthase fold, which supports small but significant differences, notably in the ordering of the C-terminus that closes the active site.
journals.iucr.org
April 2, 2025 at 12:00 AM
James A. Titterington et al.: Structures of Mycobacterium tuberculosis isoprenyl diphosphate synthase Rv2173 in substrate-bound forms ##MycobacteriumTuberculosis##IsoprenylDiphosphateSynthase##Rv2173@AucklandUni...##IUCrhttps://journals.iucr.org/paper?S2053230X25002298
Sean Teng et al.: Crystal structure of the S-adenosylmethionine-dependent mycolic acid synthase UmaA from Mycobacterium tuberculosis ##SAMDependentMycolicAcidSynthase##UmaA##MycobacteriumTuberculosis... ##IUCrhttps://journals.iucr.org/paper?S2053230X25001530
Crystal structure of the S-adenosylmethionine-dependent mycolic acid synthase UmaA from Mycobacterium tuberculosis
The crystal structure of UmaA from M. tuberculosis was solved to 1.95 Å resolution in space group P3221.
journals.iucr.org
March 11, 2025 at 1:00 AM
Sean Teng et al.: Crystal structure of the S-adenosylmethionine-dependent mycolic acid synthase UmaA from Mycobacterium tuberculosis ##SAMDependentMycolicAcidSynthase##UmaA##MycobacteriumTuberculosis... ##IUCrhttps://journals.iucr.org/paper?S2053230X25001530
It is estimated that 20% of M.tb isolates globally are resistant to at least one agent, and these strains are associated with a similar proportion of worldwide TB death
www.frontiersin.org/journals/mic...
@who.int issued 1st edi catalogue of #Mycobacteriumtuberculosis complex (MTBC) mutations
www.frontiersin.org/journals/mic...
@who.int issued 1st edi catalogue of #Mycobacteriumtuberculosis complex (MTBC) mutations
December 16, 2024 at 3:49 AM
It is estimated that 20% of M.tb isolates globally are resistant to at least one agent, and these strains are associated with a similar proportion of worldwide TB death
www.frontiersin.org/journals/mic...
@who.int issued 1st edi catalogue of #Mycobacteriumtuberculosis complex (MTBC) mutations
www.frontiersin.org/journals/mic...
@who.int issued 1st edi catalogue of #Mycobacteriumtuberculosis complex (MTBC) mutations
The N-terminal domain of hypothetical protein Rv1421 from Mycobacterium tuberculosis H37Rv was crystallized and its ligand-binding abilities were analyzed @ActaCrystF @IUCr #MycobacteriumTuberculosis #Rv1421 #WalkerABLikeMotif
t.co/1OJYXJjbyW
t.co/1OJYXJjbyW
July 8, 2024 at 2:49 PM
The N-terminal domain of hypothetical protein Rv1421 from Mycobacterium tuberculosis H37Rv was crystallized and its ligand-binding abilities were analyzed @ActaCrystF @IUCr #MycobacteriumTuberculosis #Rv1421 #WalkerABLikeMotif
t.co/1OJYXJjbyW
t.co/1OJYXJjbyW