CHAC1 emerging as #KidneyDisease #RiskGene with a central role of modulating tubule cell glutathione and #Ferroptosis doi.org/10.1126/scit... @ksusztak.bsky.social #DrugDevelopmentOption #TranslationalScience
Glutathione-specific gamma–glutamylcyclotransferase 1 (CHAC1) increases kidney disease risk by modulating ferroptosis
CHAC1 is a kidney disease risk gene, and removal of one copy of Chac1 protects mice from kidney disease by controlling glutathione and ferroptosis.
doi.org
April 24, 2025 at 7:09 PM
CHAC1 emerging as #KidneyDisease #RiskGene with a central role of modulating tubule cell glutathione and #Ferroptosis doi.org/10.1126/scit... @ksusztak.bsky.social #DrugDevelopmentOption #TranslationalScience