#CellDeathDis
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haoyin.bsky.social
#HGPS #Aortopathy

The age-related accumulation of immature Lamin A, #Progerin or Farnesyl-Prelamin A, ⏫Stretch-induced loss of aortic #SmoothMuscleCell

Comparative analysis among
1⃣LmnaG609G/+
2⃣Zmpste24-/-
3⃣SM22a-Cre::Zmpste f/f::LmnaPLAO/PLAO🐭

#CellDeathDis 2025
www.nature.com/articles/s41...
July 28, 2025 at 7:04 PM
realbiomassspec.bsky.social
Comprehensive secretome profiling and CRISPR screen identifies SFRP1 as a key inhibitor of epidermal progenitor proliferation #CellDeathDis #MassSpec www.nature.com/articles/s41...
Comprehensive secretome profiling and CRISPR screen identifies SFRP1 as a key inhibitor of epidermal progenitor proliferation - Cell Death & Disease
Cell Death & Disease - Comprehensive secretome profiling and CRISPR screen identifies SFRP1 as a key inhibitor of epidermal progenitor proliferation
www.nature.com
May 4, 2025 at 7:52 AM
haoyin.bsky.social
#EndothelialCell Robo4
👉⏬irradiation-induced #EndMT
👉Modulates #HematopoieticStemProgenitorCell quiescence & lineage potentials

Evidence of bEND3🐭microvascular EC

Robo4-KD EC coculture▶️
HSPC ⏫G0 quiescence ⏫apoptosis
⏫Erythrocyte
⏫Megakaryocyte

#CellDeathDis 2024
www.nature.com/articles/s41...
May 15, 2025 at 11:46 AM
haoyin.bsky.social
#Pericyte #TunnelingNanoTube

Pericyte-Astrocyte TNT ⏫by #OxygenGlucoseDeprivation
Pericyte-to-Astrocyte Mitochondria transfer occurs on dish (via TNT or direct contact) or in 3D #Assembloid (via TNT or not?🤔), likely⏬Astrocyte Apoptosis

#CellDeathDis 2022
www.nature.com/articles/s41...
November 19, 2024 at 8:43 PM
mattmuscleguy.bsky.social
Congrats to #jyoti_k_jaiswal, James Novak, and colleagues on their new #CellDeathDis paper: Failure to resolve inflammation contributes to juvenile onset cardiac damage in a mouse model of Duchenne muscular dystrophy. #Myoblue tinyurl.com/57p7p588
Failure to resolve inflammation contributes to juvenile onset cardiac damage in a mouse model of Duchenne muscular dystrophy - Cell Death & Disease
Cell Death & Disease - Failure to resolve inflammation contributes to juvenile onset cardiac damage in a mouse model of Duchenne muscular dystrophy
tinyurl.com
July 10, 2025 at 12:34 PM
haoyin.bsky.social
Casein kinase 2 inhibitor, TBB as a novel #Senolytic

TBB quenches DDR in senescent cells▶️
⏫unrepaired DNA damage
⏫Apoptosis

in Zmpste24 KO🐭
extends lifespan (18->24 wk)
⏫trabecular bone vol
⏬#CellularSenescence in kidney spleen

#CellDeathDis 2024
www.nature.com/articles/s41...
January 6, 2025 at 12:34 AM