##GeneRegulation
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genesndiseases.bsky.social
This review highlights the dual nature of R-loops in #GeneRegulation and #GenomeInstability, emphasizing their impact on #DNADamage responses and potential as #therapeutic targets. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...
November 2, 2025 at 12:51 AM
kseniakrasileva.bsky.social
🚀 New preprint!
We introduce K-PROB, a k-mer–based Bayesian framework that mines pangenomic promoter and expression diversity to predict cis-regulatory elements driving gene expression variation in crops 🌽🌱
🔗 biorxiv.org/content/10.1101/2025.10.27.684862v1
#Genomics #GeneRegulation #Maize #Soybean
Natural variation in regulatory code revealed through Bayesian analysis of plant pan-genomes and pan-transcriptomes
Understanding the genetic code of cis-regulatory elements (CREs) is essential for engineering gene expression and modulating agronomic traits in crops. In plants, CREs underlying rapid evolution of ge...
biorxiv.org
October 29, 2025 at 4:47 PM
christinapaliou.bsky.social
📢 We are hiring!
👩🏾‍⚕️Research technician/Lab manager
📍 @cabd-upo-csic.bsky.social , Sevilla, Spain
🧬 Gene regulation in animal development & evolution

Check the details 👇 & join us!
drive.google.com/file/d/1cZJi...

#ResearchTechnician #Zebrafish #GeneRegulation #DevelopmentalBiology
October 15, 2025 at 3:00 PM
victorchang.edu.au
Our first #PaulKornerSeminar speaker Dr Paola Cornejo @CarinaPaola12 will be presenting 'Leveraging TF-binding motif models for cross-species cell type prediction'
#MachineLearning #GeneRegulation #Genomics #Bioinformatics @em6wong
January 29, 2025 at 4:51 AM
victorchang.edu.au
Our first #PaulKornerSeminar speaker Dr Paola Cornejo @CarinaPaola12 will be presenting 'Leveraging TF-binding motif models for cross-species cell type prediction'
#MachineLearning #GeneRegulation #Genomics #Bioinformatics @em6wong
December 10, 2024 at 4:37 AM
moritzmall.bsky.social
We screened 1,296 transcription factors in 18 cell types to predict #Safeguards—#Repressors that silence plasticity. PROX1 emerged as key for hepatocytes, shutting down alternate fates & preventing #LiverCancer. Check your favorite TF here apps.embl.de/safeguard/ #GeneRegulation
February 13, 2025 at 12:16 PM
pol-kuleuven.bsky.social
🧬 Next week we’re thrilled to host Prof. Nick Gilbert (U. of Edinburgh) for a deep dive into the Structure & Dynamics of active chromatin!
🎙️ “Irregular nucleosome positioning modulates 3D structure and dynamics of active chromatin”

#Chromatin #Biophysics #GeneRegulation
June 8, 2025 at 5:37 AM
biochemcellbio.bsky.social
In ER+ breast #cancer cells, estrogen represses SOX2—a stem/progenitor gene linked to tumor progression—via enhancer modulation.
Yet its regulatory elements remain accessible, poised for reactivation.
doi.org/10.1139/bcb-...
#Epigenetics #BreastCancer #GeneRegulation
doi.org
May 30, 2025 at 1:26 PM
bioinfoadv.bsky.social
🛠️PLUS: pastboon is #opensource and available! The #Rpackage provides methods for simulating parameterized stochastic Boolean networks, supporting research in #generegulation and #signaltransduction.
CRAN: https://cran.r-project.org/package=pastboon
GitHub:
GitHub - taherimo/pastboon: Simulation of parameterized stochastic Boolean networks
Simulation of parameterized stochastic Boolean networks - taherimo/pastboon
github.com
February 14, 2025 at 2:02 PM
luigalpal.bsky.social
Promoters have strong orientation-bias, but not the enhancers

Massively parallel characterization of transcriptional regulatory elements | Nature

#transcription #generegulation #chromatin

www.nature.com/articles/s41...
Massively parallel characterization of transcriptional regulatory elements - Nature
Lentivirus-based reporter assays for 680,000 regulatory sequences from three cell lines coupled to machine-learning models lead to insights into the grammar of cis-regulatory elements.
www.nature.com
January 16, 2025 at 1:36 AM
novogene-europe.bsky.social
Discover the significance of long non-coding RNAs with Novogene’s lncRNA sequencing services. Gain insights into gene regulation and disease mechanisms.

Learn more: bit.ly/3DpuzLZ

#lncRNA #LongNonCodingRNA #RNASequencing #Transcriptomics #GeneRegulation #GenomicsInnovation
June 5, 2025 at 7:39 AM
insilicoplants.bsky.social
Improving gene regulatory network models with RNA levels in absolute units

📰 Story: https://bit.ly/3FsMON8 via @botanyone
🔬 Research: https://academic.oup.com/insilicoplants/article/3/2/diab022/6342117
by @A_J_Millar @uurquiza at @SynthSysEd in @insilicoplants
#generegulation...
December 7, 2024 at 3:25 AM
ucdavisplants.bsky.social
🧬 From PNAS: REQUIRED FOR ARBUSCULAR MYCORRHIZATION 1 (RAM1) partners with WRI transcription factors to regulate genes driving arbuscule development and nutrient exchange in Arbuscular mycorrhiza (AM) symbiosis. (Nitzan Shabek)
▶️ www.pnas.org/doi/10.1073/...
#PlantBiology #GeneRegulation
The GRAS protein RAM1 interacts with WRI transcription factors to regulate plant genes required for arbuscule development and function | PNAS
During arbuscular mycorrhiza (AM) symbiosis AM fungi form tree-shaped structures called arbuscules in root cortex cells of host plants. Arbuscules ...
www.pnas.org
May 23, 2025 at 4:07 PM
novogene-europe.bsky.social
Uncover the roles of circular RNAs in gene regulation and disease with Novogene’s circRNA sequencing services. Gain precise insights into their expression and function.

Learn more: bit.ly/3P22IE7

#circRNA #CircularRNA #RNASequencing #Transcriptomics #GeneRegulation #GenomicsInnovation
May 1, 2025 at 7:40 AM
meleckmas.bsky.social
Fantastic third instalment of the Melbourne Epigenetics Club featuring talks by Lee Wong and Hamish King, and a networking reception

If you’re in Melbourne and interested in #chromatin #epigenetics or #GeneRegulation and interested in attending, visit www.eckmaslab.com/melbourne-ep... 🧪🧬
November 19, 2024 at 9:04 AM
plosbiology.org
Post-transcriptional #GeneRegulation through #m6A deposition is dysregulated in many diseases. Samie Jaffrey &co investigate why the m6A writer complex requires multiple subunits and what roles its individual proteins might have in m6A regulation. 🧪
plos.io/3VjfjWI
Why does the m6A writer complex require so many proteins?
Post-transcriptional gene regulation through m6A deposition is dysregulated in many diseases and is catalyzed by a multi-protein writer complex. This Unsolved Mystery investigates why the writer compl...
plos.io
September 16, 2025 at 12:51 PM
origamiorganelles.bsky.social
Our Trp Operon paper model helps students understand how genes are switched on or off in E. coli to make the amino acid tryptophan, depending on its presence in the cell! Fascinating stuff! Learn more here: https://bit.ly/3YvcaU8

#trpoperon #generegulation #iteachbio #EduSky #ecoli
February 12, 2025 at 12:02 PM
eedhaene.bsky.social
Hello Bluesky! Let's see if we can make the switch. I'm a postdoc in the Eye and Developmental Genetics Lab (www.debaerelab.com) and Functional Genomics Lab (fungenlab-ugent.be) at Ghent University (BE). Working on #chromatin #epigenetics #GeneRegulation #RareDisease #StructuralVariation #SpaceOmics
November 11, 2024 at 1:11 PM
mpolychronidou.bsky.social
Complete, systematic mutagenesis mapping of 7 human enhancers active in the developing brain, heart, limb, face assesses the consequences of mutations for in vivo #enhancer activity in mouse transgenic assays ➡️ www.nature.com/articles/s41...
#generegulation #transcription #genomics
In vivo mapping of mutagenesis sensitivity of human enhancers - Nature
Human enhancers contain a high density of sequence features that are required for their normal in vivo function.
www.nature.com
June 20, 2025 at 6:47 AM
novogene-europe.bsky.social
Discover the significance of long non-coding RNAs with Novogene’s lncRNA sequencing services. Gain insights into gene regulation and disease mechanisms.

Learn more: bit.ly/3DpuzLZ

#lncRNA #LongNonCodingRNA #RNASequencing #Transcriptomics #GeneRegulation #GenomicsInnovation
September 5, 2025 at 7:30 AM
genomejournal.bsky.social
Publish your next breakthrough in Genome with no fees. Corresponding authors with @crkn-rcdr.bsky.social can submit unlimited OA manuscripts and benefit from unlimited read access. Discover how 🍁▶️ buff.ly/oUyzd2x

🧬🔄 #genomics #chromatin #nucleosome #regulatorynetwork #generegulation #epigenome
Confederation Bridge in PEI, Canada. The Canadian Science Publishing logo sits in the top left corner and the Canadian Science Publishing blaze emblem sits in the bottom right.
June 11, 2025 at 2:05 PM
febsletters.bsky.social
🎉We congratulate 🌟Mathys Grapotte 🌟 @crg.eu (CRG), on winning the FEBS Letters #PosterPrize at the CRG– @babrahaminst.bsky.social postdoc symposium on #GeneRegulation, recently held in Barcelona! 👏👏👏

@grapottem.bsky.social
#CRGBIpostdocs
March 5, 2025 at 2:31 PM
epigenometech.bsky.social
New blog article alert!

Check out part 1 of our blog series - “An Interpretable Foundation Model for Predicting Transcriptional Regulation” bit.ly/41WLzD2

Read more or our epigenetics blogs at epigenome.us/blog

#Epigenetics #Blog #Chromatin #FoundationModels #TranscriptionFactors #GeneRegulation
March 11, 2025 at 2:19 PM
impvienna.bsky.social
Are you a #postdoc with an innovative vision for starting your own lab in #Syntheticbiology, #Genomics, #GeneRegulation, #Development, #Cancer, #Immunology or #InfectionBiology?

@IMPvienna is inviting applications for group leader positions: www.imp.ac.at/career/open-...

Pls share!
November 19, 2024 at 3:08 PM
mpi-nat.bsky.social
Patrick Cramer @CramerLab is awarded this year’s Otto Warburg Medal for his groundbreaking research on the cell’s copy machine and its function in #transcription and #generegulation. Congratulations! #OWM20 @BBAjournals @ElsevierConnect https://twitter.com/GBM_eV/status/1226825012688171008
November 25, 2024 at 6:53 AM