Zuzana Hodakova
@zuzanahodakova.bsky.social
Postdoc @ Haselbach lab, IMP Vienna
ex-PhD student @ Crick London
Big fan of cryo-EM, ubiquitin biology, and Lord of the Rings
ex-PhD student @ Crick London
Big fan of cryo-EM, ubiquitin biology, and Lord of the Rings
Reposted by Zuzana Hodakova
🎄 xmas preprint 🎄 we are excited to share our cryo-EM structure of UBR4 in complex with KCMF1 and CALM1. the PQC ligase forms a massive ubiquitination arena, primed to amplify ubiquitin chains (E4 activity) and boost degradation of defective proteins. www.biorxiv.org/content/10.1...
December 21, 2024 at 10:46 AM
🎄 xmas preprint 🎄 we are excited to share our cryo-EM structure of UBR4 in complex with KCMF1 and CALM1. the PQC ligase forms a massive ubiquitination arena, primed to amplify ubiquitin chains (E4 activity) and boost degradation of defective proteins. www.biorxiv.org/content/10.1...
a great way to start posting! -
check out the recent work from our lab that I had the pleasure to be involved in - how AKIRIN2 orchestrates proteasome nuclear import >>
check out the recent work from our lab that I had the pleasure to be involved in - how AKIRIN2 orchestrates proteasome nuclear import >>
We are very excited to share our recent preprint on the nuclear import mechanism of the proteasome, driven by the multivalent adaptor AKIRIN2! www.biorxiv.org/content/10.1... 🧵 1/6
A multivalent adaptor mechanism drives the nuclear import of proteasomes
Nuclear protein homeostasis, including the turnover of transcription factors, critically depends on nuclear proteasomes. After each cell division, proteasomes need to be re-imported into the newly for...
www.biorxiv.org
December 8, 2024 at 10:07 AM
a great way to start posting! -
check out the recent work from our lab that I had the pleasure to be involved in - how AKIRIN2 orchestrates proteasome nuclear import >>
check out the recent work from our lab that I had the pleasure to be involved in - how AKIRIN2 orchestrates proteasome nuclear import >>