Yi "Joey" Zhou
@zhoujoeyyi.bsky.social
PI at Institute of Neuroscience, Chinese Academy of Sciences (http://english.cebsit.cas.cn/lab/ZhouYi/).
Studying stem cells, brain development and diseases using single-cell genomics. Alumus of Johns Hopkins Neuroscience and Penn Medicine.
Studying stem cells, brain development and diseases using single-cell genomics. Alumus of Johns Hopkins Neuroscience and Penn Medicine.
Reposted by Yi "Joey" Zhou
Very excited to share my second postdoc, now out in Science Advances! We used targeted snRNA-seq to profile four major subnuclei of the primate across three species (including humans). 1/13 www.science.org/doi/10.1126/...
Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates
Specialized cell types and links to psychiatric disorders are revealed by genetic mapping of primate amygdala neurons.
www.science.org
September 18, 2025 at 1:10 AM
Very excited to share my second postdoc, now out in Science Advances! We used targeted snRNA-seq to profile four major subnuclei of the primate across three species (including humans). 1/13 www.science.org/doi/10.1126/...
Reposted by Yi "Joey" Zhou
Final version @science.org "Recent evolution of the developing human intestine affects metabolic and barrier functions". Evolutionary preparation for microbiota, diet, and pathogen exposure is fascinating! Thank you @erc.europa.eu for supporting our vision!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
August 22, 2025 at 9:04 PM
Final version @science.org "Recent evolution of the developing human intestine affects metabolic and barrier functions". Evolutionary preparation for microbiota, diet, and pathogen exposure is fascinating! Thank you @erc.europa.eu for supporting our vision!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Yi "Joey" Zhou
Cross-species analysis of adult hippocampal neurogenesis reveals human-specific gene expression but convergent biological processes
@zhoujoeyyi.bsky.social
www.nature.com/articles/s41...
@zhoujoeyyi.bsky.social
www.nature.com/articles/s41...
Cross-species analysis of adult hippocampal neurogenesis reveals human-specific gene expression but convergent biological processes - Nature Neuroscience
Machine-learning-augmented single-nucleus transcriptomic analysis compared molecular landscapes of immature neurons in the mammalian hippocampus across species, highlighting human-specific gene expres...
www.nature.com
August 22, 2025 at 4:55 PM
Cross-species analysis of adult hippocampal neurogenesis reveals human-specific gene expression but convergent biological processes
@zhoujoeyyi.bsky.social
www.nature.com/articles/s41...
@zhoujoeyyi.bsky.social
www.nature.com/articles/s41...
Excited to share our study published in @natneuro.nature.com today! We conducted cross-species analyses of immature neurons arising from adult hippocampal neurogenesis, revealing distinct human-specific gene expression patterns but convergent biological processes. www.nature.com/articles/s41...
Cross-species analysis of adult hippocampal neurogenesis reveals human-specific gene expression but convergent biological processes - Nature Neuroscience
Machine-learning-augmented single-nucleus transcriptomic analysis compared molecular landscapes of immature neurons in the mammalian hippocampus across species, highlighting human-specific gene expres...
www.nature.com
August 11, 2025 at 11:03 AM
Excited to share our study published in @natneuro.nature.com today! We conducted cross-species analyses of immature neurons arising from adult hippocampal neurogenesis, revealing distinct human-specific gene expression patterns but convergent biological processes. www.nature.com/articles/s41...
Great work in @nature.com by @qianxuyu.bsky.social from Dr. Chris Walsh lab revealing early specification of the human cortex using spatial omics. Congratulations Xuyu!🎊🎉
Today in @nature.com , we report a spatial single-cell atlas of human cortical development, revealing surprisingly early specification of human cortical layers and areas.
We built an interactive browser to explore the spatial data: walshlab.org/research/cor...
Paper link below 👇
We built an interactive browser to explore the spatial data: walshlab.org/research/cor...
Paper link below 👇
May 15, 2025 at 3:57 AM
Great work in @nature.com by @qianxuyu.bsky.social from Dr. Chris Walsh lab revealing early specification of the human cortex using spatial omics. Congratulations Xuyu!🎊🎉
A new study in preprint from @amarsahay.bsky.social lab shows that prolonged maturation of adult-born hippocampal neurons affects hippocampal network by strengthening inhibitory brain circuitry. doi.org/10.21203/rs....
Neotenic expansion of adult-born dentate granule cells reconfigures GABAergic inhibition to enhance social memory consolidation
Adult-born dentate granule cells (abDGCs) contribute to hippocampal dentate gyrus (DG)-CA3/CA2 circuit functions in memory encoding, retrieval and consolidation. Heightened synaptic and structural pla...
doi.org
March 28, 2025 at 1:51 AM
A new study in preprint from @amarsahay.bsky.social lab shows that prolonged maturation of adult-born hippocampal neurons affects hippocampal network by strengthening inhibitory brain circuitry. doi.org/10.21203/rs....
Reposted by Yi "Joey" Zhou
New preprint out from the lab, check out thread below!
✨ We tend to think of species-specific differences as resulting from the presence of species-specific genes. In our latest work with @djabaudon.bsky.social, we show that building brains is not only about which genes you use, but also about when and where you do.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 20, 2025 at 8:55 AM
New preprint out from the lab, check out thread below!
Thank you, Dr. Boeckx, for highlighting our work ! It’s exciting to see the convergence of our findings, which suggest that lysosome function in neuronal development evolves across species in a spatiotemporal- and cell type-dependent manner, with human lysosomes playing unique roles.
I was struck by the importance of lysosomes in characterizing these human-specific features, @zhoujoeyyi.bsky.social;
this finding links well with our recent work on this pathway, CHD2 and 🧠 maturation (ping @naelnadifkasri-lab.bsky.social @ellylewerissa.bsky.social @olivieroleonardi.bsky.social)
this finding links well with our recent work on this pathway, CHD2 and 🧠 maturation (ping @naelnadifkasri-lab.bsky.social @ellylewerissa.bsky.social @olivieroleonardi.bsky.social)
www.biorxiv.org
February 19, 2025 at 7:27 AM
Thank you, Dr. Boeckx, for highlighting our work ! It’s exciting to see the convergence of our findings, which suggest that lysosome function in neuronal development evolves across species in a spatiotemporal- and cell type-dependent manner, with human lysosomes playing unique roles.
Check out our latest preprint, where we cross-compared the molecular landscapes of immature neurons in the hippocampus in different mammalian species👨🐵🐷🐭, revealing specialized features in humans. www.biorxiv.org/content/10.1...
Comparative molecular landscapes of immature neurons in the mammalian dentate gyrus across species reveal special features in humans
Immature dentate granule cells (imGCs) arising from adult hippocampal neurogenesis contribute to plasticity, learning and memory, but their evolutionary changes across species and specialized features...
www.biorxiv.org
February 19, 2025 at 7:10 AM
Check out our latest preprint, where we cross-compared the molecular landscapes of immature neurons in the hippocampus in different mammalian species👨🐵🐷🐭, revealing specialized features in humans. www.biorxiv.org/content/10.1...