Reposted by Yu-Sunny-Liu
New preprint with @gfudenberg.bsky.social
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
NIPBL dosage shapes genome folding by tuning the rate of cohesin loop extrusion
Cohesin loop extrusion is a major driver of chromosome folding, but how its dynamics are controlled to shape the genome remains elusive. Here we disentangle the contributions of the cohesin cofactors ...
www.biorxiv.org
August 16, 2025 at 3:03 AM
New preprint with @gfudenberg.bsky.social
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
Reposted by Yu-Sunny-Liu
Histone Acetylation Differentially Modulates CTCF-CTCF Loops and Intra-TAD Interactions https://www.biorxiv.org/content/10.1101/2025.07.29.667515v1
August 1, 2025 at 8:33 PM
Histone Acetylation Differentially Modulates CTCF-CTCF Loops and Intra-TAD Interactions https://www.biorxiv.org/content/10.1101/2025.07.29.667515v1
Reposted by Yu-Sunny-Liu
New work from my lab with the Brown lab on how genome folding changes during motor neuron maturation, and how this process goes awry in ALS motor neurons. Led by Dr. Ozgun Uyan.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Dynamic changes in chromosome and nuclear architecture during maturation of normal and ALS C9orf72 motor neurons
We have investigated changes in chromosome conformation, nuclear organization, and transcription during differentiation and maturation of control and mutant motor neurons harboring hexanucleotide expa...
www.biorxiv.org
September 23, 2025 at 9:13 PM
New work from my lab with the Brown lab on how genome folding changes during motor neuron maturation, and how this process goes awry in ALS motor neurons. Led by Dr. Ozgun Uyan.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Yu-Sunny-Liu
The best sign was “It’s transGENIC mice, Idiot!”
Rallying for NIH Council meetings and Study sections!! #PhillyStandsUpForScience
March 8, 2025 at 12:28 AM
The best sign was “It’s transGENIC mice, Idiot!”
Reposted by Yu-Sunny-Liu
Rallying for NIH Council meetings and Study sections!! #PhillyStandsUpForScience
March 7, 2025 at 4:57 PM
Rallying for NIH Council meetings and Study sections!! #PhillyStandsUpForScience
Reposted by Yu-Sunny-Liu
It’s great how much Stand Up For Science there is here on 🦋. There’s not so much on the other site. Science is dying over there and thriving here. #PhillyStandsUp4Science
March 8, 2025 at 12:58 AM
It’s great how much Stand Up For Science there is here on 🦋. There’s not so much on the other site. Science is dying over there and thriving here. #PhillyStandsUp4Science
Great science and meeting for free!! www.foxchase.org/epigenetics2...
Cancer Epigenetics Institute Symposium 2025: From Gene Regulation to 3D Genomes to Aging to Therapeutics | Fox Chase Cancer Center - Philadelphia PA
Date:Thursday, March 6, 2025Time:8:30 AM - 7:00 PM The Franklin Institute222 North 20th StreetPhiladelphia, PA 19103CEI Annual Free Hybrid SymposiumFrom Gene Regulation to 3D Genomes to Aging to Thera...
www.foxchase.org
February 28, 2025 at 11:26 PM
Great science and meeting for free!! www.foxchase.org/epigenetics2...
Reposted by Yu-Sunny-Liu
My big question re health and health research funding in the last few weeks is “why?” It makes no sense either politically, historically, or morally.
February 15, 2025 at 12:46 AM
My big question re health and health research funding in the last few weeks is “why?” It makes no sense either politically, historically, or morally.
Reposted by Yu-Sunny-Liu
I maxed out my credit card, emptied my savings account, and took out a loan to move from Alabama to Bethesda, MD. I don’t even qualify for unemployment since I’ve only worked at NIH for a month. I will be financially and medically devastated.
Seeking suggestions for anywhere that’s hiring!!
Seeking suggestions for anywhere that’s hiring!!
Today, along with 2,000 other NIH employees, I had to clear out my office 😭
It was truly the honor of my life to work with such incredibly passionate people focused on improving human health. I’ve never experienced a more positive culture where *everyone* cared about their job and serving others.
It was truly the honor of my life to work with such incredibly passionate people focused on improving human health. I’ve never experienced a more positive culture where *everyone* cared about their job and serving others.
February 14, 2025 at 11:49 PM
I maxed out my credit card, emptied my savings account, and took out a loan to move from Alabama to Bethesda, MD. I don’t even qualify for unemployment since I’ve only worked at NIH for a month. I will be financially and medically devastated.
Seeking suggestions for anywhere that’s hiring!!
Seeking suggestions for anywhere that’s hiring!!
Reposted by Yu-Sunny-Liu
Yes. This is the message that every scientist should be getting out right now: “Trump/Musk are killing cancer research” — it’s a political slam dunk.
Public pushback is what can stop them now. Please help 🧪. Scientists are in all 50 states, including in red areas.
Public pushback is what can stop them now. Please help 🧪. Scientists are in all 50 states, including in red areas.
In its totality what's happening at HHS & NIH is a Musk/Trump effort to shutdown almost all cancer cure research in the US. No more new cures. Cancer's brand is really in the dumps. It polls terribly. This is a political argument that is straightforward to make. talkingpointsmemo.com/edblog/nih-a...
NIH and Its Agencies Are Being Smothered
In recent days I have been inundated by reports out of HHS...
talkingpointsmemo.com
February 14, 2025 at 5:50 PM
Yes. This is the message that every scientist should be getting out right now: “Trump/Musk are killing cancer research” — it’s a political slam dunk.
Public pushback is what can stop them now. Please help 🧪. Scientists are in all 50 states, including in red areas.
Public pushback is what can stop them now. Please help 🧪. Scientists are in all 50 states, including in red areas.
Reposted by Yu-Sunny-Liu
www.embopress.org/doi/epdf/10.....
Please check out Xuhang's exciting article in MSB!
Please check out Xuhang's exciting article in MSB!
Enhanced flux potential analysis links changes in enzyme expression to metabolic flux
www.embopress.org
February 18, 2025 at 11:40 AM
www.embopress.org/doi/epdf/10.....
Please check out Xuhang's exciting article in MSB!
Please check out Xuhang's exciting article in MSB!
Reposted by Yu-Sunny-Liu
I’ll be in DC March 7th at the StandUpForScience rally. See you there! If you can’t make it to DC there will be a StandUpForScience rally in a city near you. @standupforscience.bsky.social
February 27, 2025 at 2:55 AM
I’ll be in DC March 7th at the StandUpForScience rally. See you there! If you can’t make it to DC there will be a StandUpForScience rally in a city near you. @standupforscience.bsky.social
Reposted by Yu-Sunny-Liu
Fantastic work! Congratulations!
Two papers out in Nature today! Super exciting work by an amazingly talented team - Hefei Zhang and Xuhang Li. Proud and thrilled to see these out.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A systems-level, semi-quantitative landscape of metabolic flux in C. elegans - Nature
A strategy is introduced that infers whole-animal metabolic flux wiring from transcriptional phenotypes in the nematode Caenorhabditis elegans and several features in its adult metabolism are discover...
www.nature.com
February 26, 2025 at 11:32 PM
Fantastic work! Congratulations!
Reposted by Yu-Sunny-Liu
By @katherinejwu.com
"The NIH... supported 99 percent of the drugs approved in the U.S. from 2010 to 2019. The agency has had a hand in “nearly all of our major medical breakthroughs over the past several decades,”
The NIH is in a struggle for its (and our) lives. This is existential to America:
"The NIH... supported 99 percent of the drugs approved in the U.S. from 2010 to 2019. The agency has had a hand in “nearly all of our major medical breakthroughs over the past several decades,”
The NIH is in a struggle for its (and our) lives. This is existential to America:
Inside the Collapse at NIH
Administration officials pressured NIH to avoid clear advice from the agency’s own lawyers to restart grant funding now.
www.theatlantic.com
February 27, 2025 at 5:29 PM
By @katherinejwu.com
"The NIH... supported 99 percent of the drugs approved in the U.S. from 2010 to 2019. The agency has had a hand in “nearly all of our major medical breakthroughs over the past several decades,”
The NIH is in a struggle for its (and our) lives. This is existential to America:
"The NIH... supported 99 percent of the drugs approved in the U.S. from 2010 to 2019. The agency has had a hand in “nearly all of our major medical breakthroughs over the past several decades,”
The NIH is in a struggle for its (and our) lives. This is existential to America:
This campaign needs you now
Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)
chng.it
February 12, 2025 at 8:03 AM
Reposted by Yu-Sunny-Liu
NYGC is organizing a number of efforts to address the changes to NIH IDCs and other changes to federal policy. If you are a US citizen, or in the US working in science, please consider signing this petition. The more signatures the stronger our hand in interacting with law makers. chng.it/kK2HMP5pGk
Sign the Petition
Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)
chng.it
February 10, 2025 at 3:42 PM
NYGC is organizing a number of efforts to address the changes to NIH IDCs and other changes to federal policy. If you are a US citizen, or in the US working in science, please consider signing this petition. The more signatures the stronger our hand in interacting with law makers. chng.it/kK2HMP5pGk
Reposted by Yu-Sunny-Liu
Made some slides for scientists to talk about what's been happening & what we should do next. There are probably many people better qualified than me to talk about these issues. If that's you, please, please, please consider holding some virtual advocacy training sessions for researchers this week.
The War on Science (Feb 2025 teach-in draft)
The War on Science What’s happening? What can we do about it? An interactive teach-in for biomedical researchers Please share, modify, and repurpose this template presentation (with credit). Good luck...
docs.google.com
February 10, 2025 at 6:30 AM
Made some slides for scientists to talk about what's been happening & what we should do next. There are probably many people better qualified than me to talk about these issues. If that's you, please, please, please consider holding some virtual advocacy training sessions for researchers this week.