Yolanda Perez
@yolandapereznmr.bsky.social
Senior researcher Biotransformations's 🧫 Group and 🧲 NMR Core Lead at IQAC-CSIC🔸Interested in IDPs and metalloenzymes from a structural viewpoint #NMRchat🔹 Barcelona (Spain)
🔗 www.linkedin.com/in/yolanda-perez-4797ba290
📖 ORCID: 0000-0003-3767-5346
🔗 www.linkedin.com/in/yolanda-perez-4797ba290
📖 ORCID: 0000-0003-3767-5346
Pinned
We are looking for a candidate for the postdoc Juan de la Cierva call.
If you think you would be a good fit, please send your CV, along with a brief statement outlining your research interests and details of any relevant publications before 17th November. One week left!
#NMRchat #Biocatalysis
If you think you would be a good fit, please send your CV, along with a brief statement outlining your research interests and details of any relevant publications before 17th November. One week left!
#NMRchat #Biocatalysis
Reposted by Yolanda Perez
@angewandtechemie.bsky.social (open) Ultrabroadband 1D and 2D NMR Spectroscopy, corresponding Burkhard Luy @kit.edu Dedicated to Richard R. Ernst (1933–2021) onlinelibrary.wiley.com/doi/10.1002/... #NMRchat #NMR 🧲
Ultrabroadband 1D and 2D NMR Spectroscopy
Optimal control-derived saturation pulses allow 1D and 2D NMR spectroscopy covering spectral ranges in the MHz range. Next to a multitude of nuclei even multinuclear spectra are possible.
onlinelibrary.wiley.com
November 28, 2025 at 1:33 PM
@angewandtechemie.bsky.social (open) Ultrabroadband 1D and 2D NMR Spectroscopy, corresponding Burkhard Luy @kit.edu Dedicated to Richard R. Ernst (1933–2021) onlinelibrary.wiley.com/doi/10.1002/... #NMRchat #NMR 🧲
Reposted by Yolanda Perez
Please check out our just published article
www.nature.com/articles/s41...
, in which we demonstrate a proof-of-principle example of an NH-pi #hydrogen_bond on the surface of an IDP through detection of an ultra-weak J coupling by #NMR, supported by #MD and #DFT.
www.nature.com/articles/s41...
, in which we demonstrate a proof-of-principle example of an NH-pi #hydrogen_bond on the surface of an IDP through detection of an ultra-weak J coupling by #NMR, supported by #MD and #DFT.
Direct detection of an NH-π hydrogen bond in an intrinsically disordered peptide - Nature Communications
The authors demonstrate a proof-of-principle example of an NH-π hydrogen bond on the surface of an intrinsically disordered protein through detection of weak scalar couplings by NMR, supported by Mole...
www.nature.com
November 27, 2025 at 9:24 PM
Please check out our just published article
www.nature.com/articles/s41...
, in which we demonstrate a proof-of-principle example of an NH-pi #hydrogen_bond on the surface of an IDP through detection of an ultra-weak J coupling by #NMR, supported by #MD and #DFT.
www.nature.com/articles/s41...
, in which we demonstrate a proof-of-principle example of an NH-pi #hydrogen_bond on the surface of an IDP through detection of an ultra-weak J coupling by #NMR, supported by #MD and #DFT.
Reposted by Yolanda Perez
Tomorrow, Friday, November 28, noon CET / 6 am EST, Konstantin Ivanov Intercontinental Magnetic Resonance Seminar, François-Xavier Theillet, CITCoM, Université Paris Cité, France, In-cell structural biology using NMR: overview and latest developments sites.google.com/view/nmr-sem... #NMRchat #NMR 🧲
ICONS Series
Konstantin Ivanov intercontinental magnetic resonance seminar series started on April 8, 2020. It organises seminars on a range of topics in magnetic resonance covering NMR, EPR, hyperpolarisation, co...
sites.google.com
November 27, 2025 at 6:59 PM
Tomorrow, Friday, November 28, noon CET / 6 am EST, Konstantin Ivanov Intercontinental Magnetic Resonance Seminar, François-Xavier Theillet, CITCoM, Université Paris Cité, France, In-cell structural biology using NMR: overview and latest developments sites.google.com/view/nmr-sem... #NMRchat #NMR 🧲
Reposted by Yolanda Perez
We show structural details of TDP-43's C-terminal helix assembly into functional multimers, explaining dysfunction caused by several disease mutations (in Nature Comm). Appropriate for Thanksgiving day, there is a critical tryptophan! with @mittalgrouptamu.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structural details of helix-mediated multimerization of the conserved region of TDP-43 C-terminal domain - Nature Communications
RNA-binding protein TDP-43 contains a region forming a dynamic α-helical multimer that accounts for its functional role, evolutionary conservation, and disruption in amyotrophic lateral sclerosis, mak...
www.nature.com
November 27, 2025 at 7:13 PM
We show structural details of TDP-43's C-terminal helix assembly into functional multimers, explaining dysfunction caused by several disease mutations (in Nature Comm). Appropriate for Thanksgiving day, there is a critical tryptophan! with @mittalgrouptamu.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Yolanda Perez
Proteins are dynamic structures, but structural biology often shows them as static snapshots. Inspired by long-exposure photography and generative art, I built ProteinCHAOS, an artistic tool inspired by molecular dynamics to capture protein flexibility over time, much like long-exposure images.
November 23, 2025 at 11:18 PM
Proteins are dynamic structures, but structural biology often shows them as static snapshots. Inspired by long-exposure photography and generative art, I built ProteinCHAOS, an artistic tool inspired by molecular dynamics to capture protein flexibility over time, much like long-exposure images.
Reposted by Yolanda Perez
Just out: Challenging AlphaFold in predicting proteins with large-scale allosteric transitions
Challenging AlphaFold in predicting proteins with large-scale allosteric transitions
Communications Chemistry, Published online: 26 November 2025; doi:10.1038/s42004-025-01763-0Although many proteins function by toggling between distinct conformations, most structure predictors remain limited to a single static fold. Here, the authors test the performance of AlphaFold2, AlphaFold3, and recent variants on a dataset of autoinhibited proteins exhibiting at least two functionally distinct conformations, and show that AlphaFold2 fails to reproduce the experimental structures of many autoinhibited proteins, but that it can capture conformational diversity when using uniform multiple sequence alignment subsampling.
bit.ly
November 26, 2025 at 7:59 PM
Just out: Challenging AlphaFold in predicting proteins with large-scale allosteric transitions
Reposted by Yolanda Perez
Take a look through the Instruct-ERIC Facility starter pack!
Find the technology and expertise in structural biology that you need, and receive funded access to any of these facilities through Instruct - bsky.app/starter-pack...
Find the technology and expertise in structural biology that you need, and receive funded access to any of these facilities through Instruct - bsky.app/starter-pack...
November 24, 2025 at 9:27 AM
Take a look through the Instruct-ERIC Facility starter pack!
Find the technology and expertise in structural biology that you need, and receive funded access to any of these facilities through Instruct - bsky.app/starter-pack...
Find the technology and expertise in structural biology that you need, and receive funded access to any of these facilities through Instruct - bsky.app/starter-pack...
Reposted by Yolanda Perez
Liberalismo científico, o el extraño caso del doctor Jekyll y el señor Grant www.jotdown.es/2025/11/libe...
Liberalismo científico, o el extraño caso del doctor Jekyll y el señor Grant
La investigación, como tópico de entretenimiento, siempre es una buena inversión para periódicos, películas e informativos de radio y televisión: toca temas curiosos o sensibles, luce tecnología, fome...
www.jotdown.es
November 23, 2025 at 4:11 AM
Liberalismo científico, o el extraño caso del doctor Jekyll y el señor Grant www.jotdown.es/2025/11/libe...
Reposted by Yolanda Perez
Oops. Ooooooooooooops.
I do hope that nobody has been given or denied a job/promotion based on their SpringerNature citation counts in the past 15 years.
arxiv.org/pdf/2511.01675
h/t @nathlarigaldie.bsky.social
I do hope that nobody has been given or denied a job/promotion based on their SpringerNature citation counts in the past 15 years.
arxiv.org/pdf/2511.01675
h/t @nathlarigaldie.bsky.social
November 7, 2025 at 2:02 PM
Oops. Ooooooooooooops.
I do hope that nobody has been given or denied a job/promotion based on their SpringerNature citation counts in the past 15 years.
arxiv.org/pdf/2511.01675
h/t @nathlarigaldie.bsky.social
I do hope that nobody has been given or denied a job/promotion based on their SpringerNature citation counts in the past 15 years.
arxiv.org/pdf/2511.01675
h/t @nathlarigaldie.bsky.social
Reposted by Yolanda Perez
Earlier this year Jane Evans ran an informal LinkedIn experiment: 2 women & 2 men, posted identical content at the same time. The women had a combined 154K followers, the men had only 9,389. Guess who got the highest reach? Yep, the men.
www.theguardian.com/technology/2...
www.theguardian.com/technology/2...
Bro boost: women say their LinkedIn traffic increases if they pretend to be men
Collective experiment found switching profile to ‘male’ and ‘bro-coding’ text led to big increase in reach, though site denies favouring posts by men
www.theguardian.com
November 23, 2025 at 12:51 AM
Earlier this year Jane Evans ran an informal LinkedIn experiment: 2 women & 2 men, posted identical content at the same time. The women had a combined 154K followers, the men had only 9,389. Guess who got the highest reach? Yep, the men.
www.theguardian.com/technology/2...
www.theguardian.com/technology/2...
Reposted by Yolanda Perez
This team are searching for new "Asgard archaea" to sequence.
Let's talk about why these bacteria-like organisms are so fascinating, why they're named for Norse mythology, and why looking at them is unlocking a better understanding of our own genomes.
Once considered a type of oddball bacteria🦠...
Let's talk about why these bacteria-like organisms are so fascinating, why they're named for Norse mythology, and why looking at them is unlocking a better understanding of our own genomes.
Once considered a type of oddball bacteria🦠...
#AsgardArchaea team, led by @archaeal.bsky.social fr @texasscience.bsky.social — sequencing the DNA collected fr mouth of Rio de la Plata to the continental shelf of Uruguay to detect Asgards, a group of single-celled organisms & our closest microbial relatives on the tree of life. bit.ly/3MdniTH
November 21, 2025 at 1:25 PM
This team are searching for new "Asgard archaea" to sequence.
Let's talk about why these bacteria-like organisms are so fascinating, why they're named for Norse mythology, and why looking at them is unlocking a better understanding of our own genomes.
Once considered a type of oddball bacteria🦠...
Let's talk about why these bacteria-like organisms are so fascinating, why they're named for Norse mythology, and why looking at them is unlocking a better understanding of our own genomes.
Once considered a type of oddball bacteria🦠...
Reposted by Yolanda Perez
#research #hydrogenbonding
NMR spectroscopy studies of hydrogen bonding
(Dračínský) – Coord. Chem. Rev.: doi.org/10.1016/j.cc...
@iocbprague.bsky.social @czechacademy.bsky.social
NMR spectroscopy studies of hydrogen bonding
(Dračínský) – Coord. Chem. Rev.: doi.org/10.1016/j.cc...
@iocbprague.bsky.social @czechacademy.bsky.social
November 21, 2025 at 6:19 PM
#research #hydrogenbonding
NMR spectroscopy studies of hydrogen bonding
(Dračínský) – Coord. Chem. Rev.: doi.org/10.1016/j.cc...
@iocbprague.bsky.social @czechacademy.bsky.social
NMR spectroscopy studies of hydrogen bonding
(Dračínský) – Coord. Chem. Rev.: doi.org/10.1016/j.cc...
@iocbprague.bsky.social @czechacademy.bsky.social
Reposted by Yolanda Perez
I tried the updated Gemini image generator on scientific related image prompts that have failed in the past and I am really impressed by the quality of the outputs. The first is drawing a diagram for a pocket prediction algorithm using Voronoi diagram, Delaunay triangulation and alpha shapes
November 21, 2025 at 1:14 PM
I tried the updated Gemini image generator on scientific related image prompts that have failed in the past and I am really impressed by the quality of the outputs. The first is drawing a diagram for a pocket prediction algorithm using Voronoi diagram, Delaunay triangulation and alpha shapes
Reposted by Yolanda Perez
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
November 19, 2025 at 9:16 PM
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
Reposted by Yolanda Perez
Brrrr! Bacterial cells “bundle up” for winter, turning on a set of seasonal genes that changes the molecular composition of their cell membranes.🧣
Even a Single Bacterial Cell Can Sense the Seasons Changing | Quanta Magazine
Though they live only a few hours before dividing, bacteria can anticipate the approach of cold weather and prepare for it. The discovery suggests that seasonal tracking is fundamental to life.
www.quantamagazine.org
November 20, 2025 at 9:04 PM
Brrrr! Bacterial cells “bundle up” for winter, turning on a set of seasonal genes that changes the molecular composition of their cell membranes.🧣
Reposted by Yolanda Perez
My uni and many others have tried to centralize and automate many administrative functions. What happens is that the expertise is moved out of the department and then the rest of us suckers are left to learn to become admins and deal with all the edge cases. Such has been the last 6 yrs of my life
November 20, 2025 at 1:52 AM
My uni and many others have tried to centralize and automate many administrative functions. What happens is that the expertise is moved out of the department and then the rest of us suckers are left to learn to become admins and deal with all the edge cases. Such has been the last 6 yrs of my life
Reposted by Yolanda Perez
Analytical chemistry has become extremely automated in the last 25 years, and yet shit continues to break in new and befuddling ways that AI can’t possibly parse. The “datasets” for it to learn instrument repairs from exist in the minds of experts and are significantly vibes-based.
A fair question is how much of a day's work could be outsourced to a machine? As I've become proficient with AI tools, I find that much of what takes me time (but not deep cognitive effort) can be automated. PhDs are hired, at least in part, for their thinking skills. Not all jobs require them.
November 20, 2025 at 1:16 AM
Analytical chemistry has become extremely automated in the last 25 years, and yet shit continues to break in new and befuddling ways that AI can’t possibly parse. The “datasets” for it to learn instrument repairs from exist in the minds of experts and are significantly vibes-based.
Reposted by Yolanda Perez
Lewis Kay on NMR’s Expanding Role in the Post–AlphaFold Era, from Eastern Analytical Symposium EAS 2025 www.spectroscopyonline.com/view/lewis-k... #NMRchat 🧲
November 20, 2025 at 4:33 PM
Lewis Kay on NMR’s Expanding Role in the Post–AlphaFold Era, from Eastern Analytical Symposium EAS 2025 www.spectroscopyonline.com/view/lewis-k... #NMRchat 🧲
Reposted by Yolanda Perez
New cutting-edge MRI and NMR equipments will arrive at the SeRMN-UAB, The Servei de Ressonància Magnètica Nuclear (SeRMN) at the Universitat Autònoma de Barcelona (UAB) sermn.uab.cat/2025/11/new-... #NMRnews #NMRchat 🧲
New cutting-edge MRI and NMR equipments will arrive at the SeRMN-UAB | SeRMN – NMR Service at UAB
sermn.uab.cat
November 17, 2025 at 2:44 PM
New cutting-edge MRI and NMR equipments will arrive at the SeRMN-UAB, The Servei de Ressonància Magnètica Nuclear (SeRMN) at the Universitat Autònoma de Barcelona (UAB) sermn.uab.cat/2025/11/new-... #NMRnews #NMRchat 🧲
Reposted by Yolanda Perez
#NMRchat γ effects identify preferentially populated rotamers of CH2F groups: side-chain conformations of fluorinated valine analogues in a protein https://doi.org/10.5194/mr-6-257-2025
November 17, 2025 at 1:12 PM
#NMRchat γ effects identify preferentially populated rotamers of CH2F groups: side-chain conformations of fluorinated valine analogues in a protein https://doi.org/10.5194/mr-6-257-2025
Reposted by Yolanda Perez
Our latest work is out! We combined #NMR with #Crystallography, #MD, and #ProteinMPNN to analyze the conformational dynamics of a de novo enzyme and redesigned it! Great collaboration between
@cathleenzeymer.bsky.social and the @sattler-lab.bsky.social.
www.cell.com/structure/fu...
@cathleenzeymer.bsky.social and the @sattler-lab.bsky.social.
www.cell.com/structure/fu...
November 17, 2025 at 11:28 AM
Our latest work is out! We combined #NMR with #Crystallography, #MD, and #ProteinMPNN to analyze the conformational dynamics of a de novo enzyme and redesigned it! Great collaboration between
@cathleenzeymer.bsky.social and the @sattler-lab.bsky.social.
www.cell.com/structure/fu...
@cathleenzeymer.bsky.social and the @sattler-lab.bsky.social.
www.cell.com/structure/fu...
Reposted by Yolanda Perez
The nature extinction crisis is mirrored by one in our own bodies. Both have huge implications for health
The nature extinction crisis is mirrored by one in our own bodies. Both have huge implications for health
Modern life is waging a war against ecosystems around us and inside us. Keeping our own microbes healthy is another reason to demand action to preserve the natural world
www.theguardian.com
October 31, 2025 at 6:32 PM
The nature extinction crisis is mirrored by one in our own bodies. Both have huge implications for health
Reposted by Yolanda Perez
My quote of the day
In a world where everyone is behaving honestly, any dishonesty constitutes a big infraction. But, in a world where many people are behaving dishonestly, and the news is filled with stories of their infractions, even big infractions can feel small to the perpetrator.
Dan Ariely
In a world where everyone is behaving honestly, any dishonesty constitutes a big infraction. But, in a world where many people are behaving dishonestly, and the news is filled with stories of their infractions, even big infractions can feel small to the perpetrator.
Dan Ariely
November 16, 2025 at 1:32 PM
My quote of the day
In a world where everyone is behaving honestly, any dishonesty constitutes a big infraction. But, in a world where many people are behaving dishonestly, and the news is filled with stories of their infractions, even big infractions can feel small to the perpetrator.
Dan Ariely
In a world where everyone is behaving honestly, any dishonesty constitutes a big infraction. But, in a world where many people are behaving dishonestly, and the news is filled with stories of their infractions, even big infractions can feel small to the perpetrator.
Dan Ariely
Reposted by Yolanda Perez
The importance of getting away from your screen and talking to other people: The Sense of Community (with thanks to @andrewmaynard.net for stimulating this post) occamstypewriter.org/athenedonald...
The Importance of Community | Athene Donald's Blog
occamstypewriter.org
November 16, 2025 at 10:19 AM
The importance of getting away from your screen and talking to other people: The Sense of Community (with thanks to @andrewmaynard.net for stimulating this post) occamstypewriter.org/athenedonald...
Reposted by Yolanda Perez
Indeed, two decades ago now
This should have been the end of Larry Summers.
Why women are poor at science, by Harvard president
The president of Harvard University has provoked a furore by arguing that men outperform women in maths and sciences because of biological difference, and discrimination is no longer a career barrier ...
www.theguardian.com
November 16, 2025 at 8:26 AM
Indeed, two decades ago now