Defense-associated reverse transcriptases (DRTs) employ diverse and distinctive mechanisms of cDNA synthesis to protect bacteria against viral infection. However, much of DRT family diversity remains ...

Inducible gene expression and CRISPR interference-mediated depletion in the predatory bacterium Bdellovibrio bacteriovorus.

A combination of large-scale phylogenomic analysis, mouse lethality experiments and bacterial growth assays shows that gene loss in the putrescine utilization pathway has enhanced biofilm formation an...

Abstract. Transfer RNA (tRNA) modifications have emerged as critical post-transcriptional regulators of gene expression affecting diverse biological and di

Bacterial ecospecies are a recently recognized genetic structure that is hypothesized to arise by complex adaptation to a new niche. Using coadaptation analysis as a foundation for laboratory experime...

Liu et al. report that a Vibrio-specific T6SS effector, TseVs, selectively disrupts Vibrio bioenergetics while sparing non-target microbes via an immunity-independent mechanism. This work reveals how ...

Bacterial ecospecies are a recently recognized genetic structure that is hypothesized to arise by complex adaptation to a new niche. Using coadaptation analysis as a foundation for laboratory experime...

Small noncoding RNAs typically regulate the translation initiation of target mRNAs and thereby protein production. In this issue of Molecular Cell, Thongdee et al. discovered a novel regulatory mechan...

Small noncoding RNAs typically regulate the translation initiation of target mRNAs and thereby protein production. In this issue of Molecular Cell, Thongdee et al. discovered a novel regulatory mechanism where a bacterial small RNA modulates translation elongation and co-translational folding to alter protein activity without affecting protein abundance.

Abstract. Bacteriophages with RNA genomes are among the simplest biological entities on Earth. Since their discovery in the 1960s, they have been used as i

Featuring: “Insights into the role of RNA in bacterial immunity and phage replication” Jens Hör, PhD Group Leader, Helmholtz Institute for RNA based Infection Research, Junior Professor, University...

Leveraging RNA-targeting dCas13d enables selective interference with phage protein translation and facilitates measurement of phage gene fitness at a transcriptome-wide scale.

Single-cell decisions made in complex environments underlie many bacterial phenomena. Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these approaches have been hin...

Zhou et al. identify a 9-bp deletion in a putative transcriptional regulator in P. aeruginosa. This mutation is highly associated with chronic P. aeruginosa infection and leads to pyruvate accumulatio...

Dr. CHAO Yanjie at the Shanghai Institute of Immunity and Infection of the Chinese Academy of Sciences and Dr. WANG Chuan from Fudan University revealed how a bacterial pathogen coordinates N-acetylne...